4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER

Product Name: 4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER
CAS No.: 288154-16-5
Chemical Name: 4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER
Synonyms: Z-PIP(BOC)-OH;1-BOC-4-N-CBZ-AMINOISONIPECOTIC ACID;1-Boc-4-N-Cbz-aminoisonipecotic acid, 98%;Z-4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID;Cbz-4-amino-1-Boc-piperidine-4-carboxylic acid;1-BOC-4-N-CBZ-AMINOPIPERIDINE-4-CARBOXYLIC ACID;1-Boc-4-(Cbz-amino)piperidine-4-carboxylic Acid;CBZ-4-Amino-1-Boc-Piperadine-4- Carboxylic acid;4-(Cbz-aMino)-1-Boc-piperidine-4-carboxylic acid;1-N-BOC-4-N-CBZ-AMINO-PIPERIDINE-4-CARBOXYLIC ACID
CBNumber: CB5277311
Molecular Formula: C19H26N2O6
Formula Weight: 378.42
MOL File: 288154-16-5.mol

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4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Property

Boiling point:: 556.1±50.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 3.84±0.20(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 288154-16-5(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B201210
Product name: 1-BOC-4-N-CBZ-AminoisonipecoticAcid
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 261315
Product name: Z-4-amino-1-Boc-piperidine-4-carboxylic acid
Packaging: 250mg
Price: $393
Updated: 2021/12/16

Apolloscientific

Product number: OR965510
Product name: 4-(Cbz-amino)-1-Boc-piperidine-4-carboxylicacid
Purity: 97%
Packaging: 5g
Price: $632
Updated: 2021/12/16

Chem-Impex

Product number: 14479
Product name: 1-Boc-4-N-Z-aminoisonipecoticacid,≥97%(HPLC)
Purity: ≥97%(HPLC)
Packaging: 5G
Price: $291.2
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA56167
Product name: Z-4-amino-1-Boc-piperidine-4-carboxylic acid
Packaging: 250mg
Price: $77.5
Updated: 2021/12/16

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4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Chemical Properties,Usage,Production

Chemical Properties

White powder

Synthesis

501-53-1

183673-68-9

288154-16-5

To a solution of compound 2-c (0.50 g, 2.05 mmol) in tetrahydrofuran (THF, 4 mL) was added an aqueous sodium hydroxide solution (0.17 g, 4.30 mmol, 2.10 equiv, 4 mL). The reaction mixture was cooled to 0°C. Benzyl chloroformate (0.32 mL, 2.25 mmol, 1.10 eq.) was slowly added dropwise followed by stirring at room temperature for 24 hours. Upon completion of the reaction, the reaction mixture was washed with ether, then the pH of the aqueous layer was adjusted to 2.5 with 1N hydrochloric acid and extracted with ethyl acetate. The organic layers were combined, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to afford 4-benzyloxycarbonylaminopiperidine-1,4-dicarboxylic acid mono-tert-butyl ester as a white solid (0.55 g, 71% yield), which was used directly in the next step of the reaction.1H-NMR (CDCl3) δ: 7.29-7.39 (m, 5H), 5.10 (s, 2H), 3.84 (bs, 2H). 3.05-3.15 (m, 2H), 1.95-2.12 (m, 4H), 1.45 (s, 9H).

References

[1] Patent: US2010/168421, 2010, A1. Location in patent: Page/Page column 7
[2] Patent: WO2008/150089, 2008, A1. Location in patent: Page/Page column 15

4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Suppliers

China 60 France 1 Germany 1 India 4 United Kingdom 7 United States 15 Global 88

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View Lastest Price from 4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co

Product: 4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 288154-16-5
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-02-18

288154-16-5, 4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTERRelated Search:

Ethyl 4-hydroxypiperidine-1-carboxylate N-BOC-ISONIPECOTIC ACID 4-Cbz-Aminopiperidine 1-Boc-4-Methylaminopiperidine Z-AIB-OH 1-Boc-piperidine N-Boc-4-piperidinemethanol N-alpha-Cbz-L-2,4-diamiobutyric acid 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde 4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID 1-BOC-4-CBZ-AMINO-PIPERIDINE Isopropyl 4-aminopiperidine-1-carboxylate 4-Amino-1-Boc-piperidine 4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER BENZYL METHYLPIPERIDIN-4-YLCARBAMATE (S)-3-CBZ-AMINO-BUTYLAMINE H-DAB(BOC)-OH 4-BENZYLOXYCARBONYLAMINO-4-METHYL-PIPERIDINE

Z-4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID

Z-PIP(BOC)-OH

1-N-BOC-4-N-CBZ-AMINO-PIPERIDINE-4-CARBOXYLIC ACID

4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER

4-(BENZYLOXYCARBONYLAMINO)-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-4-CARBOXYLIC ACID

1-BOC-4-N-CBZ-AMINOPIPERIDINE-4-CARBOXYLIC ACID

1,4-Piperidinedicarboxylic acid, 4-[[(phenylmethoxy)carbonyl]amino]-, 1-(1,1-dimethylethyl) ester

N-BOC-4-(N-CBZ-AMINO) PIPERIDINE-4-CARBOXYLIC ACID

1-Boc-4-(Cbz-amino)piperidine-4-carboxylic Acid

1-BOC-4-N-CBZ-AMINOISONIPECOTIC ACID

4-(Cbz-aMino)-1-Boc-piperidine-4-carboxylic acid

Cbz-4-amino-1-Boc-piperidine-4-carboxylic acid

4-[(Benzyloxycarbonyl)amino]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester

1-[(2-methylpropan-2-yl)oxycarbonyl]-4-(phenylmethoxycarbonylamino)piperidine-4-carboxylic Acid

1-(1,1-Dimethylethyl) 4-[[(phenylmethoxy)carbonyl]amino]-1,4-piperidinedicarboxylate

CBZ-4-Amino-1-Boc-Piperadine-4- Carboxylic acid

1-Boc-4-N-Cbz-aminoisonipecotic acid, 98%

4-benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester, 10 mM in DMSO

1-(tert-Butyl) 4-(N-CBZ-amino)-1,4-piperidinedicarboxylate

288154-16-5

C19H26N2O6