NAFRONYL
- Product Name
- NAFRONYL
- CAS No.
- 31329-57-4
- Chemical Name
- NAFRONYL
- Synonyms
- Tridus;Citoxid;Nafmnyl;Dubimax;Dusodril;NAFRONYL;Gevatran;Praxilene;Di-Actane;Naftidrofuryl
- CBNumber
- CB7759257
- Molecular Formula
- C24H33NO3
- Formula Weight
- 383.53
- MOL File
- 31329-57-4.mol
NAFRONYL Property
- Boiling point:
- bp0.5 190°
- Density
- d431 1.0465
- refractive index
- nD29 1.5513
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Oil
- pka
- 9.21±0.25(Predicted)
- color
- Colourless to Dark Yellow
- CAS DataBase Reference
- 31329-57-4(CAS DataBase Reference)
Safety
- Toxicity
- LD50 in mice (mg/kg): 365 orally (Bessin)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- N215000
- Product name
- Nafronyl
- Packaging
- 5mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- N215000
- Product name
- Nafronyl
- Packaging
- 50mg
- Price
- $1295
- Updated
- 2021/12/16
- Product number
- CM139840
- Product name
- 2-(Diethylamino)ethyl3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoate
- Purity
- 95%
- Packaging
- 1g
- Price
- $1870
- Updated
- 2021/12/16
- Product number
- CD31002289
- Product name
- Nafronyl
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1984
- Updated
- 2021/12/16
- Product number
- MT-56369
- Product name
- Nafronyl
- Purity
- 98%
- Packaging
- 0.5g
- Price
- $910
- Updated
- 2021/12/16
NAFRONYL Chemical Properties,Usage,Production
Originator
Dusodril,Roland,W. Germany,1968
Uses
Nafronyl is a selective inhibitor of serotonin receptors. Nafronyl is a vasodilator used in the treatment of intermittent claudication.
Uses
Vasodilator.
Definition
ChEBI: 2-(1-naphthalenylmethyl)-3-(2-oxolanyl)propanoic acid 2-(diethylamino)ethyl ester is a member of naphthalenes.
Manufacturing Process
30 grams (0.106 mol) of β-(1-naphthyl)-β'-tetrahydrofuryl isobutyric acid are
heated under reflux for 8 1/2 hours in 230 cc of isopropanol with 14 grams
(0.103 mol) of β-chloroethyl-N-diethylamine. After evaporation of the
isopropanol in vacuo, the syrupy residue is treated with a solution of K2CO3.
Extraction with ether is carried out after drying over Na2SO4.
Distillation of the extract yields 28.5 grams of a very viscous yellow liquid with
a BP0.95-1.09millibar = 198° to 202°C. The yield is 70.5% (theoretical quantity =
40.5 grams).1.3 grams (0.0103 mol) of dihydrated oxalic acid are dissolved
while being made tepid in 8 cc of acetone. The cooled solution has added
thereto 4 grams (0.0104 mol) of N-diethylaminoethyl-β-(1-naphthyl)-β'-
tetrahydrofuryl isobutyrate, obtained according to the process described above
and dissolved in 10 cc of acetone. The solution is brought to boiling point for
15 minutes. After cooling to ambient temperature, it is placed in a
refrigerator. Crystallization occurs after 2 hours, the crystals which have
formed are separated by centrifuging, and after washing in hexane and drying
in vacuo 3.5 grams of white crystals are obtained. After being recrystallized
three times, in alcohol and then in a mixture of alcohol and ethyl acetate, the
product is analytically pure and has a MP = 110° to 111°C (heating stage).
brand name
Praxilene (Lipha, S.A., France).
Therapeutic Function
Vasodilator
World Health Organization (WHO)
Naftidrofuryl is a vasoactive spasmolytic used to treat peripheral vascular disease. It also improves the oxygen utilization in tissues.
NAFRONYL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from NAFRONYL manufacturers
- Product
- Nafronyl 31329-57-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-11
- Product
- NAFRONYL 31329-57-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-12
- Product
- NAFRONYL 31329-57-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-30