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NAFRONYL

Product Name
NAFRONYL
CAS No.
31329-57-4
Chemical Name
NAFRONYL
Synonyms
Tridus;Citoxid;Nafmnyl;Dubimax;Dusodril;NAFRONYL;Gevatran;Praxilene;Di-Actane;Naftidrofuryl
CBNumber
CB7759257
Molecular Formula
C24H33NO3
Formula Weight
383.53
MOL File
31329-57-4.mol
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NAFRONYL Property

Boiling point:
bp0.5 190°
Density 
d431 1.0465
refractive index 
nD29 1.5513
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Oil
pka
9.21±0.25(Predicted)
color 
Colourless to Dark Yellow
CAS DataBase Reference
31329-57-4(CAS DataBase Reference)
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Safety

Toxicity
LD50 in mice (mg/kg): 365 orally (Bessin)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
N215000
Product name
Nafronyl
Packaging
5mg
Price
$160
Updated
2021/12/16
TRC
Product number
N215000
Product name
Nafronyl
Packaging
50mg
Price
$1295
Updated
2021/12/16
Chemenu
Product number
CM139840
Product name
2-(Diethylamino)ethyl3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoate
Purity
95%
Packaging
1g
Price
$1870
Updated
2021/12/16
Crysdot
Product number
CD31002289
Product name
Nafronyl
Purity
95+%
Packaging
1g
Price
$1984
Updated
2021/12/16
AHH
Product number
MT-56369
Product name
Nafronyl
Purity
98%
Packaging
0.5g
Price
$910
Updated
2021/12/16
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NAFRONYL Chemical Properties,Usage,Production

Chemical Properties

Boiling point: 190°C/66.7 Pa. D431: 1.0465. ND29: 1.5513. Acute toxicity LD5050 in mice (mg/kg): 365 oral dose. Naftidrofuryl Oxalate: C24H33NO3?C2H2O4. [3200-06-4]. Crystallized from ethyl acetate, melting point: 110-111°C. Slightly hygroscopic. Soluble in water.

Originator

Dusodril,Roland,W. Germany,1968

Uses

Vasodilator.

Uses

Nafronyl is a selective inhibitor of serotonin receptors. Nafronyl is a vasodilator used in the treatment of intermittent claudication.

Definition

ChEBI: 2-(1-naphthalenylmethyl)-3-(2-oxolanyl)propanoic acid 2-(diethylamino)ethyl ester is a member of naphthalenes.

Manufacturing Process

30 grams (0.106 mol) of β-(1-naphthyl)-β'-tetrahydrofuryl isobutyric acid are heated under reflux for 8 1/2 hours in 230 cc of isopropanol with 14 grams (0.103 mol) of β-chloroethyl-N-diethylamine. After evaporation of the isopropanol in vacuo, the syrupy residue is treated with a solution of K2CO3. Extraction with ether is carried out after drying over Na2SO4.
Distillation of the extract yields 28.5 grams of a very viscous yellow liquid with a BP0.95-1.09millibar = 198° to 202°C. The yield is 70.5% (theoretical quantity = 40.5 grams).1.3 grams (0.0103 mol) of dihydrated oxalic acid are dissolved while being made tepid in 8 cc of acetone. The cooled solution has added thereto 4 grams (0.0104 mol) of N-diethylaminoethyl-β-(1-naphthyl)-β'- tetrahydrofuryl isobutyrate, obtained according to the process described above and dissolved in 10 cc of acetone. The solution is brought to boiling point for 15 minutes. After cooling to ambient temperature, it is placed in a refrigerator. Crystallization occurs after 2 hours, the crystals which have formed are separated by centrifuging, and after washing in hexane and drying in vacuo 3.5 grams of white crystals are obtained. After being recrystallized three times, in alcohol and then in a mixture of alcohol and ethyl acetate, the product is analytically pure and has a MP = 110° to 111°C (heating stage).

brand name

Praxilene (Lipha, S.A., France).

Therapeutic Function

Vasodilator

World Health Organization (WHO)

Naftidrofuryl is a vasoactive spasmolytic used to treat peripheral vascular disease. It also improves the oxygen utilization in tissues.

NAFRONYL Preparation Products And Raw materials

Raw materials

Benzyl chloride N,N-Dimethylformamide alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Diethylaminoethanol Sodium ethoxide Alkali Metals, plasma standard solution, Specpure, Ba,Be,Ca,Cs,K,Li,Mg,Na,Rb,Sr, 100μg/ml

Preparation Products

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NAFRONYL Suppliers

Canada 1 China 28 Europe 2 Germany 1 India 2 South Korea 1 United Kingdom 3 United States 11 Global 49
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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Chemsky (shanghai) International Co.,Ltd
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021-50135380
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shchemsky@sina.com
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Suzhou APIC Biotechnology Co., Ltd.
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0512-65757861-8000
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sales@apiclab.cn
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Raw material medicin reagent co.,Ltd
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sales@njromanme.com
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China
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 +86-13028896684;
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sales@rrkchem.com
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China
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Baoji Guokang Healthchem co.,ltd
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+8615604608665 15604608665
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dominicguo@gk-bio.com
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CHINA
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Chemwill Asia Co.,Ltd.
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86-21-51086038
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chemwill_asia@126.com
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career henan chemical co
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0086-371-86658258
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Santa Cruz Biotechnology Inc
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XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.
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View Lastest Price from NAFRONYL manufacturers

Career Henan Chemical Co
Product
NAFRONYL 31329-57-4
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2019-12-30

31329-57-4, NAFRONYLRelated Search:

NAFRONYL OXALATE SALT,NAFRONYL OXALATE,Nafronyl acid oxalate,Nafronyl oxalate salt ,98%,Nafronyl oxalate salt ,99% NAFRONYL 2-(3-PHENYLPROPYL)TETRAHYDROFURAN NAFTIDROFURYL IMPURITY C NAFTIDROFURYL IMPURITY A NAFTIDROFURYL - REFERENCE SPECTRUM 1-(TETRAHYDRO-2-FURYL)-3-(1-NAPHTHYL) PROPANE-2-CARBOXYLIC ACID NAFTIDROFURYL IMPURITY B NAFTIDROFURYL IMPURITY F NAFTIDROFURYL HYDROGEN OXALATE NAFTIDROFURYL IMPURITY C3-[(NAPHTALEN-1-YL)-2-[(NAPHTALEN-1-YL)METHYL]PROPANOATE EPY(CRM STANDARD) NAFTIDROFURYL OXALATE ASSAY STANDARD BP(CRM STANDARD) NAFTIDROFURYL IMPURITY A2-[(NAPHTALEN-1-YL)METHYL]-3-(TETRAHYDROFURAN-2-YL)PROPANOIC ACID EPY(CRM STANDARD) NAFTIDROFURYL IMPURITY F2-[(DIETHYLAMINO)ETHYL 2-[(NAPHTHALEN-2-YL)METHYL]-3-(TETRAHYDROFURAN-2-YL)PROPANOATE EPY(CRM STANDARD) NAFTIDROFURYL OXALATE BP STANDARD(CRM STANDARD) NAFTIDROFURYL IMPURITY B2-[(NAPHTALEN-1-YL)METHYL]-3-(TETRAHYDROFURAN-2-YL)PROPANOATE EPY(CRM STANDARD) NAFTIDROFURYL HYDROGEN OXALATE MM(CRM STANDARD) NAFTIDROFURYL HYDROGEN OXALATE REFERENCE SPECTRUM EPY(CRM STANDARD)

  • 3-NAPHTHALEN-1-YL-2-(TETRAHYDRO-FURAN-2-YLMETHYL)-PROPIONIC ACID 2-DIETHYLAMINO-ETHYL ESTER
  • Citoxid
  • Di-Actane
  • Dusodril
  • Nafmnyl
  • Praxilene
  • 2-(Diethylamino)ethyl 3-(1-naphthyl)-2-(tetrahydro-2-furanylmethyl)propanoate
  • 2-(Diethylamino)ethyl ester tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanic acid
  • 2-(Diethylamino)ethyl tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionate
  • 2-(diethylamino)ethyltetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionate
  • tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionicaci2-(diethylamino)et
  • Tridus
  • NAFRONYL
  • Tetrahydro-α-(1-naphthalenylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester
  • Tetrahydro-α-(1-naphtylmethyl)-2-furanpropionic acid 2-(diethylamino)ethyl ester
  • Tetrahydro-α-(1-naphthalenylMethyl)-
  • 2-(DiethylaMino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)Methyl)propanoate
  • 2-Furanpropanoic acid, tetrahydro-alpha-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl ester
  • 2-Furanpropionic acid, tetrahydro-alpha-(1-naphthylmethyl)-, 2-(diethylamino)ethyl ester
  • 3-(1-Naphthyl)-2-tetrahydrofurfurylpropionic acid 2-(diethylamino)ethyl ester
  • 3-(1-naphthyl)-2-tetrahydrofurfurylpropionicacid2-(diethylamino)ethylester
  • alpha-Tetrahydrofurfuryl-1-naphthalenepropionic acid 2-(diethylamino)ethyl ester
  • alpha-tetrahydrofurfuryl-1-naphthalenepropionicacid2-(diethylamino)ethyles
  • Dubimax
  • Gevatran
  • Naftidrofuryl
  • N-Diethylaminoethyl beta-(1-naphthyl)-beta-tetrahydrofuryl isobutyrate
  • n-diethylaminoethylbeta-(1-naphthyl)-beta-tetrahydrofurylisobutyrate
  • Tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester
  • tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanoicacid2-(diethylamino
  • Tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester
  • tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropanoicacid2-(diethylamino)eth
  • 2-Furanpropanoic acid, tetrahydro-α-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl ester
  • NAFRONYL USP/EP/BP
  • 2-Furanpropanoic acid, tetrahydro-?alpha?-(1-naphthalenylmethyl)
  • Naphthofuramide ester
  • 31329-57-4
  • C24H33NO3
  • Amines
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals