alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate
- Product Name
- alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate
- CAS No.
- 3200-06-4
- Chemical Name
- alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate
- Synonyms
- ls121;Iridus;eu-1806;CLARANTIN;Acid oxalate;NAFRONYL OXALATE;naftidrofuryloxalate;Nafronyl acid oxalate;hylester,oxalate(1:1);NAFRONYL OXALATE SALT
- CBNumber
- CB5426302
- Molecular Formula
- C26H35NO7
- Formula Weight
- 473.56
- MOL File
- 3200-06-4.mol
alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Property
- Melting point:
- 110-111°
- Boiling point:
- 574°C (rough estimate)
- Density
- 1.2205 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Freely soluble in water, freely soluble or soluble in ethanol (96 per cent), slightly or sparingly soluble in acetone.
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- N1391
- Product name
- Nafronyl oxalate salt
- Purity
- analytical standard
- Packaging
- 5G
- Price
- $100
- Updated
- 2024/03/01
- Product number
- BP362
- Product name
- Naftidrofuryl oxalate
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $219
- Updated
- 2023/06/20
- Product number
- API0006883
- Product name
- NAFTIDROFURYL OXALATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $479.85
- Updated
- 2021/12/16
- Product number
- API0006883
- Product name
- NAFTIDROFURYL OXALATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $841.71
- Updated
- 2021/12/16
- Product number
- CS-4704
- Product name
- Naftidrofuryloxalate
- Purity
- 95.81%
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Chemical Properties,Usage,Production
Chemical Properties
White solid
Originator
Dusodril,Roland,W. Germany,1968
Uses
antineoplastic
Manufacturing Process
30 grams (0.106 mol) of β-(1-naphthyl)-β'-tetrahydrofuryl isobutyric acid are
heated under reflux for 8 1/2 hours in 230 cc of isopropanol with 14 grams
(0.103 mol) of β-chloroethyl-N-diethylamine. After evaporation of the
isopropanol in vacuo, the syrupy residue is treated with a solution of K2CO3.
Extraction with ether is carried out after drying over Na2SO4.
Distillation of the extract yields 28.5 grams of a very viscous yellow liquid with
a BP0.95-1.09millibar = 198° to 202°C. The yield is 70.5% (theoretical quantity =
40.5 grams).1.3 grams (0.0103 mol) of dihydrated oxalic acid are dissolved
while being made tepid in 8 cc of acetone. The cooled solution has added
thereto 4 grams (0.0104 mol) of N-diethylaminoethyl-β-(1-naphthyl)-β'-
tetrahydrofuryl isobutyrate, obtained according to the process described above
and dissolved in 10 cc of acetone. The solution is brought to boiling point for
15 minutes. After cooling to ambient temperature, it is placed in a
refrigerator. Crystallization occurs after 2 hours, the crystals which have
formed are separated by centrifuging, and after washing in hexane and drying
in vacuo 3.5 grams of white crystals are obtained. After being recrystallized
three times, in alcohol and then in a mixture of alcohol and ethyl acetate, the
product is analytically pure and has a MP = 110° to 111°C (heating stage).
brand name
Praxilene (Lipha, S.A., France).
Therapeutic Function
Vasodilator
Clinical Use
Vasodilator:
Peripheral and cerebral vascular disease
Metabolism
Metabolised by plasma pseudo-cholinesterases to 3 active metabolites.
alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate manufacturers
- Product
- alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate 3200-06-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-12