alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate

ChemicalBook > CAS DataBase List > alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate

alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate

Product Name: alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate
CAS No.: 3200-06-4
Chemical Name: alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate
Synonyms: ls121;Iridus;eu-1806;CLARANTIN;Acid oxalate;NAFRONYL OXALATE;naftidrofuryloxalate;Nafronyl acid oxalate;hylester,oxalate(1:1);NAFRONYL OXALATE SALT
CBNumber: CB5426302
Molecular Formula: C26H35NO7
Formula Weight: 473.56
MOL File: 3200-06-4.mol

Less

alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Property

Melting point:: 110-111°
Boiling point:: 574°C (rough estimate)
Density: 1.2205 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Store at -20°C
solubility: Freely soluble in water, freely soluble or soluble in ethanol (96 per cent), slightly or sparingly soluble in acetone.

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: LU5805000
HS Code: 29321900
Toxicity: LD50 oral in rat: 711mg/kg

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N1391
Product name: Nafronyl oxalate salt
Purity: analytical standard
Packaging: 5G
Price: $100
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP362
Product name: Naftidrofuryl oxalate
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $219
Updated: 2023/06/20

American Custom Chemicals Corporation

Product number: API0006883
Product name: NAFTIDROFURYL OXALATE
Purity: 95.00%
Packaging: 1G
Price: $479.85
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006883
Product name: NAFTIDROFURYL OXALATE
Purity: 95.00%
Packaging: 5G
Price: $841.71
Updated: 2021/12/16

ChemScene

Product number: CS-4704
Product name: Naftidrofuryloxalate
Purity: 95.81%
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Less

alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Chemical Properties,Usage,Production

Chemical Properties

White solid

Originator

Dusodril,Roland,W. Germany,1968

Uses

antineoplastic

Manufacturing Process

30 grams (0.106 mol) of β-(1-naphthyl)-β'-tetrahydrofuryl isobutyric acid are heated under reflux for 8 1/2 hours in 230 cc of isopropanol with 14 grams (0.103 mol) of β-chloroethyl-N-diethylamine. After evaporation of the isopropanol in vacuo, the syrupy residue is treated with a solution of K2CO3. Extraction with ether is carried out after drying over Na2SO4.
Distillation of the extract yields 28.5 grams of a very viscous yellow liquid with a BP0.95-1.09millibar = 198° to 202°C. The yield is 70.5% (theoretical quantity = 40.5 grams).1.3 grams (0.0103 mol) of dihydrated oxalic acid are dissolved while being made tepid in 8 cc of acetone. The cooled solution has added thereto 4 grams (0.0104 mol) of N-diethylaminoethyl-β-(1-naphthyl)-β'- tetrahydrofuryl isobutyrate, obtained according to the process described above and dissolved in 10 cc of acetone. The solution is brought to boiling point for 15 minutes. After cooling to ambient temperature, it is placed in a refrigerator. Crystallization occurs after 2 hours, the crystals which have formed are separated by centrifuging, and after washing in hexane and drying in vacuo 3.5 grams of white crystals are obtained. After being recrystallized three times, in alcohol and then in a mixture of alcohol and ethyl acetate, the product is analytically pure and has a MP = 110° to 111°C (heating stage).

brand name

Praxilene (Lipha, S.A., France).

Therapeutic Function

Vasodilator

Clinical Use

Vasodilator:
Peripheral and cerebral vascular disease

Metabolism

Metabolised by plasma pseudo-cholinesterases to 3 active metabolites.

alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Preparation Products And Raw materials

Raw materials

Oxalic acid Tetrahydrofurfuryl bromide Ethanol Potassium hydroxide Acetone Toluene Sodium 1-Chloromethyl naphthalene Diethylaminoethanol Sodium ethoxide Sodium Methoxide Hydrochloric acid Dichloromethane Sodium hydroxide Diethyl malonate Isopropyl alcohol Thionyl chloride

Preparation Products

NAFRONYL

Less

alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Suppliers

China 60 Germany 1 India 4 South Korea 1 Switzerland 1 United Kingdom 2 United States 23 Global 92

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9664
Advantage: 60

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3750
Advantage: 55

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3123
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17994
Advantage: 56

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9503
Advantage: 50

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3868
Advantage: 58

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9604
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel: 025-57798860
Email: sales@njromanme.com
Country: China
ProdList: 4534
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: 571-85586718 +8613336195806
Fax: +86-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 29797
Advantage: 60

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17997
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4698
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418671
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34572
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 28455
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: CHINA
ProdList: 52867
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: 0571-85134551 18958018566;
Fax: 008657185134895
Email: info@afinechem.com
Country: China
ProdList: 15377
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 9126
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23931
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49391
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-81138252 +86-18789408387
Fax: 029-88380327
Email: 1057@dideu.com
Country: China
ProdList: 2954
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: chenjw@absin.cn
Country: China
ProdList: 24734
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4196
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-61856359 18690052321
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10010
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4576
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
Advantage: 58

NORANA GROUP

Tel: 027-027-59209883 17386169806
Fax: 027-59209883
Email: service@nornachem.com
Country: China
ProdList: 4604
Advantage: 58

Mainchem Co., Ltd.

Tel: --
Fax: --
Email: sarah@mainchem.com
Country: China
ProdList: 6572
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 9946
Advantage: 58

Beijing Nordhuns Chemical Technology Co.,Ltd

Tel: 010-84929330 13811281791
Fax: 010-84926806
Email: info@nordhuns.com
Country: China
ProdList: 259
Advantage: 58

Zhuhai Anzhe Biotechnology Co,Ltd.

Tel: 13169972583
Email: 513211116@qq.com
Country: China
ProdList: 3015
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 29778
Advantage: 58

Hubei Yunmei Technology Co., Ltd

Tel: 027-59206672 18327059871
Email: service@yunmeichem.com
Country: China
ProdList: 5001
Advantage: 58

Pushan Industry (Shaanxi) Co., Ltd.

Tel: 029-81310890 13571859809
Email: info@pushanshiye.com
Country: China
ProdList: 10004
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 11572
Advantage: 58

Hubei Enxing Biotechnology Co., Ltd

Tel: 16621771607
Email: exbio_tech@163.com
Country: China
ProdList: 8352
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: +86-18521732826
Email: market@aladdin-e.com
Country: China
ProdList: 48467
Advantage: 58

Henan Tianfu Chemical Co.,Ltd.

Tel: +86-0371-55170693 +86-19937530512
Fax: 0371-55170693
Email: info@tianfuchem.com
Country: China
ProdList: 21689
Advantage: 55

LEAPCHEM CO., LTD.

Tel: +86-852-30606658
Email: market18@leapchem.com
Country: China
ProdList: 43348
Advantage: 58

Hebei Guanlang Biotechnology Co., Ltd.

Tel: +86-19930503259 +86-19930503259
Email: cherry@crovellbio.com
Country: China
ProdList: 18451
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 50000
Advantage: 58

PT CHEM GROUP LIMITED

Tel: +86-85511178 +86-85511178
Email: peter68@ptchemgroup.com
Country: China
ProdList: 35453
Advantage: 58

Hebei Duling International Trade Co. LTD

Tel: +8618712993135
Fax: 0311-87836622
Email: sales01@hbduling.cn
Country: China
ProdList: 15741
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: market@xlswkj.com
Country: CHINA
ProdList: 6805
Advantage: 58

Nanjing Sai Ruirui Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: sales@shrbio.com
Country: CHINA
ProdList: 6873
Advantage: 58

Shanghai Hengdu Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2305876186@qq.com
Country: CHINA
ProdList: 3160
Advantage: 58

Shanghai Jingke Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: jingkehuaxue@163.com
Country: CHINA
ProdList: 6974
Advantage: 58

Shanghai Yubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 344843571@qq.com
Country: CHINA
ProdList: 6322
Advantage: 58

Less

View Lastest Price from alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Nafronyl Oxalate 3200-06-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-11

Dideu Industries Group Limited

Product: alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate 3200-06-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-12

3200-06-4, alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalateRelated Search:

SODIUM BINOXALATE Oxalic acid 1-ethyl ester OXALIC ACID BIS[2,4,5-TRICHLORO-6-(PENTYLOXYCARBONYL)PHENYL] ESTER Diethylamine alpha-(1-Naphthylmethyl)tetrahydro-2-furanpropionic acid 2-piperidinoe thyl ester oxalate 1-N-HEXYLNAPHTHALENE 2-(3-PHENYLPROPYL)TETRAHYDROFURAN alpha-(1-Naphthylmethyl)tetrahydro-2-furanpropionic acid 2-(dimethylam ino)ethyl ester oxalate 1-(TETRAHYDRO-2-FURYL)-3-(1-NAPHTHYL) PROPANE-2-CARBOXYLIC ACID NAFRONYL 3-(1-NAPHTHYL)-PROPIONIC ACID alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate

2-(diethylamino)ethyltetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionateo

eu-1806

hylester,oxalate(1:1)

ls121

naftidrofuryloxalate

diethyl[2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl]ammonium hydrogen oxalate

CLARANTIN

Nafronyl acid oxalate

α-(1-naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester

alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate

ALPHA-[1-NAPHTHYLMETHYL]-2-TETRAHYDROFURANPROPIONIC ACID DIETHYLAMINOETHYL ESTER OXALATE SALT

NAFRONYL OXALATE

NAFRONYL OXALATE SALT

2-(Diethylamino)ethyl tetrahydro-.alpha.-(1-naphthylmethyl)-2-furanpropionate oxalate (1:1)

2-Furanpropanoic acid, tetrahydro-.alpha.-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl ester, ethanedioate (1:1)

2-Furanpropionic acid, tetrahydro-.alpha.-(1-naphthylmethyl)-, 2-(diethylamino)ethyl ester oxalate (1:1)

2-Furanpropionic acid, tetrahydro-.alpha.-(1-naphthylmethyl)-, 2-(diethylamino)ethyl esteroxalate (1:1)

Iridus

Nafronyl oxalate salt ,96%

2-(DiethylaMino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)Methyl)propanoate oxalate

Nafronyl oxalate salt ,99%

Nafronyl oxalate salt ,98%

α-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate

Acid oxalate

Nafronyl oxalate salt USP/EP/BP

alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate USP/EP/BP

5-hydroxytryptamine Receptor,Inhibitor,Naftidrofuryl oxalate,Serotonin Receptor,Naftidrofuryl,inhibit,5-HT Receptor,Nafronyl

2-Furanpropanoic acid, tetrahydro-a-(1-naphthalenylmethyl)-,2-(diethylamino)ethyl ester, ethanedioate (1:1)

3200-06-4

C24H33NO3C2H2O4

C26H34NO7

NA - NI

Analytical Standards

Analytical Chromatography Product Catalog

Alphabetic

CASODEX