alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate

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alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate

Product Name: alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate
CAS No.: 3200-06-4
Chemical Name: alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate
Synonyms: ls121;Iridus;eu-1806;CLARANTIN;Acid oxalate;NAFRONYL OXALATE;naftidrofuryloxalate;Nafronyl acid oxalate;hylester,oxalate(1:1);NAFRONYL OXALATE SALT
CBNumber: CB5426302
Molecular Formula: C26H35NO7
Formula Weight: 473.56
MOL File: 3200-06-4.mol

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alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Property

Melting point:: 110-111°
Boiling point:: 574°C (rough estimate)
Density: 1.2205 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Store at -20°C
solubility: Freely soluble in water, freely soluble or soluble in ethanol (96 per cent), slightly or sparingly soluble in acetone.
form: Solid
color: White to off-white

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: LU5805000
HS Code: 29321900
Toxicity: LD50 oral in rat: 711mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N1391
Product name: Nafronyl oxalate salt
Purity: analytical standard
Packaging: 5G
Price: $100
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP362
Product name: Naftidrofuryl oxalate
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $219
Updated: 2023/06/20

American Custom Chemicals Corporation

Product number: API0006883
Product name: NAFTIDROFURYL OXALATE
Purity: 95.00%
Packaging: 1G
Price: $479.85
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006883
Product name: NAFTIDROFURYL OXALATE
Purity: 95.00%
Packaging: 5G
Price: $841.71
Updated: 2021/12/16

ChemScene

Product number: CS-4704
Product name: Naftidrofuryloxalate
Purity: 95.81%
Packaging: 100mg
Price: $60
Updated: 2021/12/16

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alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Chemical Properties,Usage,Production

Chemical Properties

White solid

Originator

Dusodril,Roland,W. Germany,1968

Uses

antineoplastic

Manufacturing Process

30 grams (0.106 mol) of β-(1-naphthyl)-β'-tetrahydrofuryl isobutyric acid are heated under reflux for 8 1/2 hours in 230 cc of isopropanol with 14 grams (0.103 mol) of β-chloroethyl-N-diethylamine. After evaporation of the isopropanol in vacuo, the syrupy residue is treated with a solution of K2CO3. Extraction with ether is carried out after drying over Na2SO4.
Distillation of the extract yields 28.5 grams of a very viscous yellow liquid with a BP0.95-1.09millibar = 198° to 202°C. The yield is 70.5% (theoretical quantity = 40.5 grams).1.3 grams (0.0103 mol) of dihydrated oxalic acid are dissolved while being made tepid in 8 cc of acetone. The cooled solution has added thereto 4 grams (0.0104 mol) of N-diethylaminoethyl-β-(1-naphthyl)-β'- tetrahydrofuryl isobutyrate, obtained according to the process described above and dissolved in 10 cc of acetone. The solution is brought to boiling point for 15 minutes. After cooling to ambient temperature, it is placed in a refrigerator. Crystallization occurs after 2 hours, the crystals which have formed are separated by centrifuging, and after washing in hexane and drying in vacuo 3.5 grams of white crystals are obtained. After being recrystallized three times, in alcohol and then in a mixture of alcohol and ethyl acetate, the product is analytically pure and has a MP = 110° to 111°C (heating stage).

brand name

Praxilene (Lipha, S.A., France).

Therapeutic Function

Vasodilator

Clinical Use

Vasodilator:
Peripheral and cerebral vascular disease

Metabolism

Metabolised by plasma pseudo-cholinesterases to 3 active metabolites.

alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Preparation Products And Raw materials

Raw materials

Oxalic acid Tetrahydrofurfuryl bromide Ethanol Potassium hydroxide Acetone Toluene Sodium 1-Chloromethyl naphthalene Diethylaminoethanol Sodium ethoxide Sodium Methoxide Hydrochloric acid Dichloromethane Sodium hydroxide Diethyl malonate Isopropyl alcohol Thionyl chloride

Preparation Products

NAFRONYL

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View Lastest Price from alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate manufacturers

Dideu Industries Group Limited

Product: alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate 3200-06-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-12

3200-06-4, alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalateRelated Search:

SODIUM BINOXALATE Oxalic acid 1-ethyl ester OXALIC ACID BIS[2,4,5-TRICHLORO-6-(PENTYLOXYCARBONYL)PHENYL] ESTER Diethylamine alpha-(1-Naphthylmethyl)tetrahydro-2-furanpropionic acid 2-piperidinoe thyl ester oxalate 1-N-HEXYLNAPHTHALENE 2-(3-PHENYLPROPYL)TETRAHYDROFURAN alpha-(1-Naphthylmethyl)tetrahydro-2-furanpropionic acid 2-(dimethylam ino)ethyl ester oxalate 1-(TETRAHYDRO-2-FURYL)-3-(1-NAPHTHYL) PROPANE-2-CARBOXYLIC ACID NAFRONYL 3-(1-NAPHTHYL)-PROPIONIC ACID alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate

2-(diethylamino)ethyltetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionateo

eu-1806

hylester,oxalate(1:1)

ls121

naftidrofuryloxalate

diethyl[2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl]ammonium hydrogen oxalate

CLARANTIN

Nafronyl acid oxalate

α-(1-naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester

alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate

ALPHA-[1-NAPHTHYLMETHYL]-2-TETRAHYDROFURANPROPIONIC ACID DIETHYLAMINOETHYL ESTER OXALATE SALT

NAFRONYL OXALATE

NAFRONYL OXALATE SALT

2-(Diethylamino)ethyl tetrahydro-.alpha.-(1-naphthylmethyl)-2-furanpropionate oxalate (1:1)

2-Furanpropanoic acid, tetrahydro-.alpha.-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl ester, ethanedioate (1:1)

2-Furanpropionic acid, tetrahydro-.alpha.-(1-naphthylmethyl)-, 2-(diethylamino)ethyl ester oxalate (1:1)

2-Furanpropionic acid, tetrahydro-.alpha.-(1-naphthylmethyl)-, 2-(diethylamino)ethyl esteroxalate (1:1)

Iridus

Nafronyl oxalate salt ,96%

2-(DiethylaMino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)Methyl)propanoate oxalate

Nafronyl oxalate salt ,99%

Nafronyl oxalate salt ,98%

α-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate

Acid oxalate

Nafronyl oxalate salt USP/EP/BP

alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate USP/EP/BP

5-hydroxytryptamine Receptor,Inhibitor,Naftidrofuryl oxalate,Serotonin Receptor,Naftidrofuryl,inhibit,5-HT Receptor,Nafronyl

2-Furanpropanoic acid, tetrahydro-a-(1-naphthalenylmethyl)-,2-(diethylamino)ethyl ester, ethanedioate (1:1)

3200-06-4

C24H33NO3C2H2O4

C26H34NO7

NA - NI

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