Cefmenoxime

ChemicalBook > CAS DataBase List > Cefmenoxime

Product Name: Cefmenoxime
CAS No.: 65085-01-0
Chemical Name: Cefmenoxime
Synonyms: CMX;SCE 1365;AB 50912;CEFMENOXIME;Cefotaxime Isomer;Cefmenoxime USP/EP/BP;7β-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazole-5-yl)thio]methyl]cepham-3-ene-4-carboxylic acid;(6R,7R)-7-[[(Z)-(2-Aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(6R,7R)-7α-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;[6R-[6α，7β(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-y1)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oet-2-ene-2-carboxylic acid
CBNumber: CB7771510
Molecular Formula: C16H17N9O5S3
Formula Weight: 511.56
MOL File: 65085-01-0.mol

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Cefmenoxime Property

Density: 1.96±0.1 g/cm3(Predicted)
pka: 2.61±0.50(Predicted)
CAS DataBase Reference: 65085-01-0(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C242838
Product name: Cefmenoxime
Packaging: 10mg
Price: $580
Updated: 2021/12/16

TRC

Product number: C242838
Product name: Cefmenoxime
Packaging: 25mg
Price: $1155
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007249
Product name: CEFMENOXIME
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

AHH

Product number: MT-49073
Product name: Cefmenoxime
Purity: 98%
Packaging: 0.1g
Price: $910
Updated: 2021/12/16

AvaChem

Product number: 2848
Product name: Cefmenoxime
Packaging: 25mg
Price: $55
Updated: 2021/12/16

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Cefmenoxime Chemical Properties,Usage,Production

Originator

Tacef,Takeda,W. Germany,1983

Uses

Cefmenoxime (cas# 65085-01-0) is a compound useful in organic synthesis.

Uses

Antibacterial.

Definition

ChEBI: A third-generation cephalosporin antibiotic, bearing a 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino group at the 7beta-position and a [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl group at the 3-position.

Manufacturing Process

7β-[α-Methoxyimino-α-(2-aminothiazol-4-yl)acetamido]cephalosporanicacid trifluoroacetic acid salt is dissolved in a solution of 272 mg of 1-methyl-5- mercapto-1H-tetrazole, 555 mg of sodium bicarbonate and 68 mg of triethylbenzylammonium bromide in 10 ml of water. The solution is heated at 60°C in nitrogen atmosphere for 6 hours. After cooling, the reaction solution is passed through a column of Amberlite XAD-2 and eluted with water and then with 2.5% ethanol. The procedure yields sodium 7β-[α-methoxyimino-α- (2-aminothiazol-4-yl)acetamido]-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3- cephem-4-carboxylate, MP 174°C to 175°C (decomposition).

brand name

Cefmax (TAP).

Therapeutic Function

Antibacterial

Antimicrobial activity

A semisynthetic cephalosporin supplied as the hydrochloride. Its activity is very similar to that of cefotaxime. A 500 mg intramuscular injection achieves a plasma concentration of 15 mg/L after 40 min. A concentration of 200 mg/L is attained after intravenous administration of 1 g. The plasma half-life is c. 1 h. Around 77% is protein bound. Probenecid increases peak plasma levels and extends the plasma half-life to 1.8 h. Therapeutic concentrations are achieved in CSF. There is a degradation product with a long half-life (around 40 h), but 80–92% of the drug is recovered unchanged from the urine. In patients with renal insufficiency, no significant relation was found between creatinine clearance and peak serum concentrations but there was a linear relationship with plasma half-life and total body clearance. About 10% of the dose appears in the feces, mostly extensively degraded, possibly by the fecal flora.
Toxicity, side effects and clinical use are those common to group 4 cephalosporins.

Cefmenoxime Preparation Products And Raw materials

Raw materials

Three B Lithium tert-butoxide Acetate Ammonium bromide 1H-TETRAZOLE Nitrogen Cefotaxime sodium Trifluoroacetic acid Bromobenzene Cefotaxime N,N-Dimethylacetamide

Preparation Products

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View Lastest Price from Cefmenoxime manufacturers

Shanghai Chinqesen Biotechnology Co., Ltd.

Product: Cefmenoxime 65085-01-0
Price: US $30.00-20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000000
Release date: 2023-10-31

Hebei Lingding Biotechnology Co., Ltd.

Product: Cefmenoxime 65085-01-0
Price: US $240.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 9000kg/per week
Release date: 2023-11-30

Hebei Mojin Biotechnology Co., Ltd

Product: Cefmenoxime 65085-01-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-06-20

65085-01-0, CefmenoximeRelated Search:

7-(5-amino-5-carboxyvaleramido)cephalosporanic acid 2-Methyl-4-isothiazolin-3-one Cephalexin PENICILLINASE Ceftizoxime sodium Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) 2-Mercapto-5-methyl-1,3,4-thiadiazole 2-(2-Aminothiazol-4-yl)glyoxylic acid Cefotaxime sodium 2,2'-Dithiobis(benzothiazole) Cefotaxime Benzothiazole Ceftizoxime Fosthiazate 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid 2Cefmenoxime·Hydrochloride,CEFMENOXIME HCL,CEFMENOXIME HYDROCHLORIDE 7-TMCA Cefetamet hydrochloride

CEFMENOXIME

(6r-(6alpha,7beta(z)))-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

(6R,7R)-7-[[(Z)-(2-Aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7α-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7β-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazole-5-yl)thio]methyl]cepham-3-ene-4-carboxylic acid

CMX

(6R,7R)-7-[(2E)-2-(2-aMino-1,3-thiazol-4-yl)-2-(MethoxyiMino)acetaMido]-3-{[(1-Methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]Methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, [6R-[6α,7β(Z)]]-

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)-

AB 50912

SCE 1365

[6R-[6α，7β(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-y1)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oet-2-ene-2-carboxylic acid

Cefotaxime Isomer

(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)-

Cefmenoxime USP/EP/BP

65085-01-0

C16H17N9O5S3

Pharmaceutical intermediate