ChemicalBook > CAS DataBase List > AG 490

AG 490

Product Name
AG 490
CAS No.
134036-52-5
Chemical Name
AG 490
Synonyms
AG 490;(E/Z)-AG490;TYRPHOSTIN B42;AG 490 USP/EP/BP;TYROPHOSTIN AG490;TYRPHOSTIN AG 490;(E/Z)-Tyrphostin B42;AG 490, Tryphostin B42;(E/Z)-Tyrphostin AG490;TYRPHOSTIN AG 490, 99+%
CBNumber
CB7779213
Molecular Formula
C17H14N2O3
Formula Weight
294.3
MOL File
134036-52-5.mol
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AG 490 Property

Melting point:
215
Boiling point:
615.2±55.0 °C(Predicted)
Density 
1.337±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
ethanol: 5 mg/mL
form 
solid
pka
8.82±0.35(Predicted)
color 
yellow
CAS DataBase Reference
134036-52-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-50-25
Safety Statements 
26-36-61-45
WGK Germany 
1
Hazard Note 
Irritant/Keep Cold under -20C
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J61715
Product name
Tyrphostin B42, 99+%
Packaging
25mg
Price
$178
Updated
2021/12/16
Alfa Aesar
Product number
J61715
Product name
Tyrphostin B42, 99+%
Packaging
100mg
Price
$329
Updated
2021/12/16
Tocris
Product number
0414
Product name
AG 490
Purity
≥99%(HPLC)
Packaging
50
Price
$520
Updated
2021/12/16
Tocris
Product number
0414
Product name
AG 490
Purity
≥99%(HPLC)
Packaging
10
Price
$124
Updated
2021/12/16
Usbiological
Product number
T9250-15
Product name
Tyrphostin AG 490
Packaging
25mg
Price
$239
Updated
2021/12/16
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AG 490 Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow-Green Crystal

Uses

A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.

Uses

Tyrphostin B42 is used in acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors.

Definition

ChEBI: Tyrphostin B42 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antioxidant, a STAT3 inhibitor, an anti-inflammatory agent, an apoptosis inducer and a geroprotector. It is an enamide, a monocarboxylic acid amide, a nitrile, a member of catechols and a secondary carboxamide.

AG 490 Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 490 Suppliers

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134036-52-5, AG 490Related Search:

AG 213 NS-398 N-Benzylacrylamide Tyrphostin AG 490 (N-benzyl-3,4-dihydroxy-benzylidenecyanoacetamide) (A) Tyrphostin AG 490 (N-benzyl-3,4-dihydroxy-benzylidenecyanoacetamide) AG 490 (Tyrphostin AG 490),AG 490,TYROPHOSTIN AG490,TYRPHOSTIN AG 490

  • AG 490, Tryphostin B42
  • 2-Cyano-3-(3,4-dihydroxyphenyl)-N-benzylacrylamide
  • N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)propenamide
  • TYRPHOSTIN AG 490
  • TYROPHOSTIN AG490
  • TYRPHOSTIN B42
  • TYRPHOSTIN AG 490, 99+%
  • N-Benzyl-2-(3,4-dihydroxybenzylidene)-2-cyanoacetamide
  • (E)-2-CYANO-3-(3,4-DIHYDROPHENYL)-N-(PHENYLMETHYL)-2-PROPENAMIDE
  • ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE
  • AG 490
  • A-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMAMIDE
  • A-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE
  • 2-CYANO-3-[3,4-DIHYDROXYPHENYL]-N-[PHENYLMETHYL]-2-PROPENAMIDE
  • N-BENZYL-3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE
  • N-BENZYL-3,4-DIHYDROXY-BENZYLIDENECYANOACETAMIDE
  • 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-
  • AG 490 USP/EP/BP
  • (E/Z)-AG490
  • (E/Z)-Tyrphostin AG490
  • (E/Z)-Tyrphostin B42
  • 134036-52-5
  • 34036-52-5
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Kinase/Phosphatase Biology
  • Janus Kinase (JAK)
  • Non-Receptor Tyrosine Kinase Inhibitors
  • Inhibitor
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • All Inhibitors
  • Inhibitors
  • Tyrosine Kinase Inhibitors