ChemicalBook > CAS DataBase List > AG 490

AG 490

Product Name: AG 490
CAS No.: 134036-52-5
Chemical Name: AG 490
Synonyms: AG 490;(E/Z)-AG490;TYRPHOSTIN B42;AG 490 USP/EP/BP;TYROPHOSTIN AG490;TYRPHOSTIN AG 490;(E/Z)-Tyrphostin B42;AG 490, Tryphostin B42;(E/Z)-Tyrphostin AG490;TYRPHOSTIN AG 490, 99+%
CBNumber: CB7779213
Molecular Formula: C17H14N2O3
Formula Weight: 294.3
MOL File: 134036-52-5.mol

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AG 490 Property

Melting point:: 215
Boiling point:: 615.2±55.0 °C(Predicted)
Density: 1.337±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: ethanol: 5 mg/mL
form: solid
pka: 8.82±0.35(Predicted)
color: yellow
CAS DataBase Reference: 134036-52-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-50-25
Safety Statements: 26-36-61-45
WGK Germany: 1
Hazard Note: Irritant/Keep Cold under -20C
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 658411
Product name: AG490
Purity: InSolution, ≥98%, inhibitor of EGFR kinase autophosphorylation
Packaging: 5mg
Price: $74.5
Updated: 2025/07/31

Tocris

Product number: 0414
Product name: AG 490
Purity: ≥99%(HPLC)
Packaging: 50
Price: $520
Updated: 2021/12/16

Tocris

Product number: 0414
Product name: AG 490
Purity: ≥99%(HPLC)
Packaging: 10
Price: $124
Updated: 2021/12/16

Usbiological

Product number: T9250-15
Product name: Tyrphostin AG 490
Packaging: 25mg
Price: $239
Updated: 2021/12/16

TRC

Product number: A425000
Product name: AG 490
Packaging: 10mg
Price: $95
Updated: 2021/12/16

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AG 490 Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow-Green Crystal

Uses

A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.

Uses

Tyrphostin B42 is used in acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors.

Definition

ChEBI: Tyrphostin B42 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antioxidant, a STAT3 inhibitor, an anti-inflammatory agent, an apoptosis inducer and a geroprotector. It is an enamide, a monocarboxylic acid amide, a nitrile, a member of catechols and a secondary carboxamide.

AG 490 Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 490 Suppliers

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134036-52-5, AG 490Related Search:

AG 213 NS-398 N-Benzylacrylamide Tyrphostin AG 490 (N-benzyl-3,4-dihydroxy-benzylidenecyanoacetamide) (A) Tyrphostin AG 490 (N-benzyl-3,4-dihydroxy-benzylidenecyanoacetamide) AG 490 (Tyrphostin AG 490),AG 490,TYROPHOSTIN AG490,TYRPHOSTIN AG 490

AG 490, Tryphostin B42

2-Cyano-3-(3,4-dihydroxyphenyl)-N-benzylacrylamide

N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)propenamide

TYRPHOSTIN AG 490

TYROPHOSTIN AG490

TYRPHOSTIN B42

TYRPHOSTIN AG 490, 99+%

N-Benzyl-2-(3,4-dihydroxybenzylidene)-2-cyanoacetamide

(E)-2-CYANO-3-(3,4-DIHYDROPHENYL)-N-(PHENYLMETHYL)-2-PROPENAMIDE

ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE

AG 490

A-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMAMIDE

A-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE

2-CYANO-3-[3,4-DIHYDROXYPHENYL]-N-[PHENYLMETHYL]-2-PROPENAMIDE

N-BENZYL-3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE

N-BENZYL-3,4-DIHYDROXY-BENZYLIDENECYANOACETAMIDE

2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-

AG 490 USP/EP/BP

(E/Z)-AG490

(E/Z)-Tyrphostin AG490

(E/Z)-Tyrphostin B42

AG490 (Synonyms: Tyrphostin AG490

134036-52-5

34036-52-5

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Kinase/Phosphatase Biology

Janus Kinase (JAK)

Non-Receptor Tyrosine Kinase Inhibitors

Inhibitor

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

All Inhibitors

Inhibitors

Tyrosine Kinase Inhibitors