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FMOC-VAL-OSU

Product Name
FMOC-VAL-OSU
CAS No.
130878-68-1
Chemical Name
FMOC-VAL-OSU
Synonyms
FMOC-VAL-OSU;Fmoc-Val-0su;Fmoc-L-Val-OSu;FMOC-VALINE-OSU;Fmoc-L-valine-osu;FMOC-VAL-OSUFMOC-V;Fmoc-Val-OSu, 98%, Fmoc-amino acids;N-Fmoc-L-valine N-succinimidyl ester;Trastuzumab Impurity 1 (Fmoc-Val-Osu);N-Fmoc-L-valineN-succinimidylester,95%
CBNumber
CB7779662
Molecular Formula
C24H24N2O6
Formula Weight
436.46
MOL File
130878-68-1.mol
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FMOC-VAL-OSU Property

Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
10.09±0.46(Predicted)
form 
Powder
color 
Off-white to white
optical activity
Consistent with structure
Water Solubility 
Slightly soluble in water.
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Safety

Safety Statements 
24/25
HS Code 
29251900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological
Product number
450869
Product name
Fmoc-Val-Osu
Packaging
100mg
Price
$305
Updated
2021/12/16
Usbiological
Product number
276075
Product name
Fmoc-L-valine N-hydroxysuccinimide ester
Packaging
25g
Price
$523
Updated
2021/12/16
TRC
Product number
F861083
Product name
Fmoc-Val-Osu
Packaging
1g
Price
$75
Updated
2021/12/16
TRC
Product number
F861083
Product name
Fmoc-Val-Osu
Packaging
100mg
Price
$45
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK598773
Product name
Fmoc-Val-OSu,98%,Fmoc-aminoacids
Packaging
1g
Price
$46
Updated
2021/12/16
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FMOC-VAL-OSU Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

N-Fmoc-L-valine N-succinimidyl ester is useful for solid phase peptide synthesis techniques.

Synthesis

6066-82-6

68858-20-8

130878-68-1

Dicyclohexylcarbodiimide (1.55 g, 7.52 mmol) and N-hydroxysuccinimide (762 mg, 6.63 mmol) were sequentially added to a stirred solution of Fmoc-L-valine (1.5 g, 4.42 mmol) in dichloromethane (25 mL) at room temperature. The reaction mixture was stirred continuously for 3 hours at room temperature. Upon completion of the reaction, the white solid dicyclohexylurea produced in the reaction was removed by filtration. The organic phase was washed sequentially with 0.1 N HCl solution and deionized water, followed by drying with anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by fast column chromatography using 1% dichloromethane solution in methanol as eluent to give the final target product (S)-2,5-dioxopyrrolidin-1-yl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutyrate as a white solid (1.7 g, 89% yield). Mass spectrum (MS): m/z 459 [M + Na]+. 1H NMR (400 MHz, CDCl3) δ 7.80 (d, J = 7.5 Hz, 2H), 7.68-7.55 (m, 2H), 7.43 (t, J = 7.4 Hz, 2H), 7.34 (dd, J = 15.9, 8.5 Hz, 2H), 4.70 (d, J = 4.6 Hz, 1H), 4.56-4.40 (m, 3H), 4.28 (t, J = 6.6 Hz, 1H), 2.85 (s, 4H), 2.37 (dd, J = 12.3, 6.5 Hz, 1H), 1.08 (dd, J = 11.0, 6.9 Hz, 6H).

References

[1] Journal of Pharmaceutical Sciences, 1994, vol. 83, # 7, p. 999 - 1005
[2] Langmuir, 2010, vol. 26, # 7, p. 4990 - 4998
[3] Patent: WO2018/178060, 2018, A1. Location in patent: Page/Page column 64-66
[4] Journal of the American Chemical Society, 2015, vol. 137, # 21, p. 6932 - 6940
[5] Patent: US2017/247324, 2017, A1. Location in patent: Paragraph 0284; 0285

FMOC-VAL-OSU Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-VAL-OSU Suppliers

China 143 Germany 3 India 5 United Kingdom 1 United States 14 Global 166
A.J Chemicals
Tel
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Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
CHEMSWORTH
Tel
--
Fax
--
Email
info@chemsworth.com
Country
India
ProdList
6700
Advantage
30
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View Lastest Price from FMOC-VAL-OSU manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
FMOC-VAL-OSU 130878-68-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
2000
Release date
2025-04-21
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-L-Val-Osu 130878-68-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-22
Sichuan Jiaying Lai Technology Co.,LTD
Product
fmoc-val-osu 130878-68-1
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-24

130878-68-1, FMOC-VAL-OSURelated Search:

Fmoc-THr(Bzl)-OH FMOC-PRO-OPFP FMOC-D-MET-OPFP FMOC-L-Valine FMOC-D-VAL-OPFP FMOC-TYR(TBU)-OPFP FMOC-TYR(SO3H)-OH SODIUM SALT FMOC-D-TYR(TBU)-OPFP FMOC-D-PRO-OPFP FMOC-D-SER(TBU)-OPFP FMOC-D-THR(TBU)-OPFP L-Valine FMOC-GLY-OSU FMOC-ILE-OSU FMOC-ALA-OSU FMOC-VAL-OSU FMOC-VAL-OSU FMOC-L-VALINOL

  • CarbaMic acid, [1-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]-2-Methylpropyl]-, 9H-fluoren-9-ylMethyl ester, (S)-
  • L-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-,2,5-dioxo-1-pyrrolidinyl ester
  • N-Fmoc-L-valine N-succinimidyl ester
  • Fmoc-L-valineN-hydroxysuccinimide ester≥ 99% (HPLC)
  • FMOC-L-VALINE N-HYDROXYSUCCINIMIDE ESTER
  • FMOC-VAL-OSU
  • FMOC-VALINE-OSU
  • NALPHA-9-Fluorenylmethoxycarbonyl-L-valine N-hydroxysuccinimide ester
  • Fmoc-L-Val-OSu
  • N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-valine succinimidyl ester
  • (S)-2,5-dioxopyrrolidin-1-yl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-methylbutanoate
  • N-alpha-FMoc-L-valine N-hydroxysucciniMide ester
  • [(1S)-1-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]-2-methylpropyl] 9H-fluoren-9-ylmethyl carbamate
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine 2,5-dioxo-1-pyrrolidinyl ester
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Val-OSu
  • Fmoc-Val-OSu, 98%, Fmoc-amino acids
  • FMOC-VAL-OSUFMOC-V
  • 2,5-dioxopyrrolidin-1-yl (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanoate
  • N-Fmoc-L-valineN-succinimidylester,95%
  • Fmoc-L-valine-osu
  • Trastuzumab Impurity 1 (Fmoc-Val-Osu)
  • Fmoc-Val-0su
  • 2,5-dioxopyrrolidin-1-yl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-valinate
  • 130878-68-1
  • Fmoc-Amino Acids and Derivatives
  • Fmoc-Amino acid series
  • Amino Acids