1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE

Uses

Product Name: 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE
CAS No.: 268550-48-7
Chemical Name: 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE
Synonyms: CPD0982;8-Boc-2,8-diazaspiro[4.5]decan-1-one;8-Boc-1-oxo-2,8-diazaspiro[4.5]decane;1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDIN;1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate;1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE;2,8-Diazaspiro[4.5]decan-1-one, N8-BOC protected;tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carbo;TERT-BUTYL 1-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE;1-Oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester
CBNumber: CB7792225
Molecular Formula: C13H22N2O3
Formula Weight: 254.33
MOL File: 268550-48-7.mol

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1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE Property

Boiling point:: 424.9±38.0 °C(Predicted)
Density: 1.15
storage temp.: 2-8°C
pka: 16.00±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C13H22N2O3/c1-12(2,3)18-11(17)15-8-5-13(6-9-15)4-7-14-10(13)16/h4-9H2,1-3H3,(H,14,16)
InChIKey: ADPIEGXXCABJCH-UHFFFAOYSA-N
SMILES: C1(=O)C2(CCN(C(OC(C)(C)C)=O)CC2)CCN1

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Safety

HazardClass: IRRITANT
HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B694580
Product name: tert-Butyl1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate
Packaging: 500mg
Price: $220
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141682
Product name: tert-Butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate
Packaging: 50mg
Price: $69
Updated: 2021/12/16

Synthonix

Product number: B0956
Product name: tert-Butyl1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate
Purity: 99%
Packaging: 1g
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 066674
Product name: tert-Butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate
Packaging: 500mg
Price: $108
Updated: 2021/12/16

Activate Scientific

Product number: AS13147
Product name: 8-Boc-2,8-diazaspiro[4.5]decan-1-one
Purity: 95+%
Packaging: 1g
Price: $115
Updated: 2021/12/16

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1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE Chemical Properties,Usage,Production

Uses

1-O-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester is a carboxylic acid ester derivative that can be used as a pharmaceutical intermediate in pharmaceutical experimental research and synthesis.

Synthesis

495414-81-8

268550-48-7

B) Synthesis of tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate 4-(Cyanomethyl)-1,4-piperidinedicarboxylic acid-1-(1,1-dimethylethyl)4-ethyl ester (2.5 g) was dissolved in methanol (50 mL), and cobalt(II) chloride hexahydrate (1.0 g) and sodium borohydride (1.6 g) were added sequentially under ice bath cooling. The reaction mixture was stirred by keeping the ice bath cool for 2 h. Subsequently, the ice bath was removed and stirring was continued for 2 h at room temperature. The reaction system was then warmed to 60°C for 1 hour. After completion of the reaction, 28% ammonia solution was added to the system and the resulting precipitate was removed by filtration. The filtrate was extracted with ethyl acetate, the organic layers were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography (eluent: ethyl acetate) to afford the target compound tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate (1.1 g). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 1.25-1.35 (2H, m), 1.40 (9H, s), 1.45-1.58 (2H, m), 1.90-1.98 (2H, m), 2.90 (2H, brs), 3.16 (2H, t, J=7.2Hz), 3.76-3.86 ( 2H, m), 7.56 (1H, brs).

References

[1] Patent: EP2933247, 2015, A1. Location in patent: Paragraph 0334

1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE Suppliers

China 120 India 1 United Kingdom 1 United States 9 Global 131

Shanghai AQBioPharma Co., Ltd.

Tel: 13661411401
Fax: 51370935-8011
Email: yinglv.que@aqbiopharma.com.cn
Country: China
ProdList: 2930
Advantage: 58

Cangzhou Dimai Technology Co., Ltd

Tel: 1351-2466848 13512466848
Fax: QQ:94204388
Email: hbdypharm@163.com
Country: China
ProdList: 244
Advantage: 58

Shanghai AQ BioPharma Co., Ltd.

Tel: 13512160998
Email: sales@aqbiopharma.com.cn
Country: China
ProdList: 2961
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

NOTA Chemical (Shanghai) Co.,Ltd

Tel: 021-50189163
Fax: 021-51687927
Email: sales@notachem.com
Country: China
ProdList: 205
Advantage: 64

Santai Labs, Inc.

Tel: 519-85601385
Fax: +86 519 8560 1389
Email: marketing@santailabs.com
Country: China
ProdList: 891
Advantage: 62

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

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View Lastest Price from 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate 268550-48-7
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-05

Pharmahands (Taizhou) Co., Ltd.

Product: tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate 268550-48-7
Price: US $890.00/Kg/Bag
Min. Order: 1g
Purity: 98%
Supply Ability: 20kg/month
Release date: 2020-10-30

Career Henan Chemical Co

Product: 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE 268550-48-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

268550-48-7, 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINERelated Search:

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE 2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER 3-[N-(2-AMINO)BENZYL-2-PYRROLIDINONE]-4'-N-BOC-SPIRO-PIPERIDINE 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE 3-[N-(3-AMINO)BENZYL-2-PYRROLIDINONE]-4'-N-BOC-SPIRO-PIPERIDINE 3-[N-(4-AMINO)BENZYL-2-PYRROLIDINONE]-4'-N-BOC-SPIRO-PIPERIDINE 1-BOC-4-FORMYL-4-METHYL-PIPERIDINE

1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE

TERT-BUTYL 1-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE

2,8-Diazaspiro[4.5]decane-8-carboxylicacid,1-oxo-,1,1-dimethylethylester

1-Oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester

1-Oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate

8-Boc-1-oxo-2,8-diazaspiro[4.5]decane

tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carbo

8-Boc-2,8-diazaspiro[4.5]decan-1-one

CPD0982

1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDIN

tert-Butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate - [B0956]

2,8-Diazaspiro[4.5]decan-1-one, N8-BOC protected

268550-48-7