Thalidomide-O-PEG4-amine

Product Name: Thalidomide-O-PEG4-amine
CAS No.: 2401832-00-4
Chemical Name: Thalidomide-O-PEG4-amine
Synonyms: Thalidomide-O-PEG4-NH2;Thalidomide-O-PEG4-amine;4-((14-amino-3,6,9,12-tetraoxatetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[(14-amino-3,6,9,12-tetraoxatetradec-1-yl)oxy]-2-(2,6-dioxo-3-piperidinyl)-;4-[(14-amino-3,6,9,12-tetraoxatetradecan-1-yl)oxy]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CBNumber: CB78054840
Molecular Formula: C23H31N3O9
Formula Weight: 493.51
MOL File: 2401832-00-4.mol

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Thalidomide-O-PEG4-amine Property

Boiling point:: 690.9±55.0 °C(Predicted)
Density: 1.321±0.06 g/cm3(Predicted)
pka: 10.70±0.40(Predicted)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24435
Product name: Thalidomide-O-PEG4-Amine
Purity: 98%
Packaging: 100mg
Price: $540
Updated: 2021/12/16

BroadPharm

Product number: BP-24435
Product name: Thalidomide-O-PEG4-Amine
Purity: 98%
Packaging: 250mg
Price: $980
Updated: 2021/12/16

BroadPharm

Product number: BP-24435
Product name: Thalidomide-O-PEG4-Amine
Purity: 98%
Packaging: 500mg
Price: $1760
Updated: 2021/12/16

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Thalidomide-O-PEG4-amine Chemical Properties,Usage,Production

Description

Thalidomide-O-PEG4-Amine is synthesized compound that can react with NHS ester group or carboxylic acid in the presence of EDC or HATU

Uses

Thalidomide-O-PEG4-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

IC 50

Cereblon

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Thalidomide-O-PEG4-amine Preparation Products And Raw materials

Raw materials

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Thalidomide-O-PEG4-amine Suppliers

China 22 United States 1 Global 23

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2401832-00-4, Thalidomide-O-PEG4-amineRelated Search:

Thalidomide-4-O-C8-NH2 Thalidomide-O-PEG4-Boc 2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Thalidomide-O-PEG4-NHS ester 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Thalidomide-O-PEG3-amine HCl Acetamide, N-[2-[3-[3-(2-aminoethoxy)propoxy]propoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Thalidomide-O-PEG4-azide

Thalidomide-O-PEG4-amine

4-((14-amino-3,6,9,12-tetraoxatetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Thalidomide-O-PEG4-NH2

1H-Isoindole-1,3(2H)-dione, 4-[(14-amino-3,6,9,12-tetraoxatetradec-1-yl)oxy]-2-(2,6-dioxo-3-piperidinyl)-

4-[(14-amino-3,6,9,12-tetraoxatetradecan-1-yl)oxy]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

2401832-00-4

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