1-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE
- Product Name
- 1-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE
- CAS No.
- 73930-39-9
- Chemical Name
- 1-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE
- Synonyms
- 1-Phenylcyclopropan-1-amine hydrochloride;TIMTEC-BB SBB008643;1-PhenylcyclopropylaMine HCl;1-PhenylcyclopropanaMine, HCl;1-Phenyl-cyclopropylamine hydroc;1-Phenylcyclopropanamine Hydrochloride;1-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE;cyclopropanamine, 1-phenyl-, hydrochloride;1-Phenylcyclopropan-1-aminehydrochloride95%;1-phenyl-cyclopropylamine HCL form, 95%min
- CBNumber
- CB7836835
- Molecular Formula
- C9H12ClN
- Formula Weight
- 169.65128
- MOL File
- 73930-39-9.mol
1-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE Property
- Melting point:
- 194.7-194.9 °C
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C9H11N.ClH/c10-9(6-7-9)8-4-2-1-3-5-8;/h1-5H,6-7,10H2;1H
- InChIKey
- ABUWJOHYZALSMF-UHFFFAOYSA-N
- SMILES
- C1(N)(C2=CC=CC=C2)CC1.Cl
Safety
- HazardClass
- IRRITANT
- HS Code
- 2921490090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- OTV000611
- Product name
- 1-Phenylcyclopropanamine hydrochloride
- Packaging
- 1 g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- P3138
- Product name
- 1-Phenylcyclopropan-1-amine Hydrochloride
- Packaging
- 200MG
- Price
- $60
- Updated
- 2025/07/31
- Product number
- P3138
- Product name
- 1-Phenylcyclopropan-1-amine Hydrochloride
- Packaging
- 1G
- Price
- $150
- Updated
- 2025/07/31
- Product number
- P336613
- Product name
- 1-PhenylcyclopropanamineHydrochloride
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-B0486
- Product name
- Cyclopropanamine,1-phenyl-,(Hydrochloride)1:1
- Purity
- 99.77%
- Packaging
- 1g
- Price
- $54
- Updated
- 2021/12/16
1-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE Chemical Properties,Usage,Production
Synthesis
6120-95-2
73930-39-9
The general procedure for the synthesis of 1-phenylcyclopropanamine hydrochloride from 1-phenyl-1-cyclopropanecarboxylic acid is as follows: first, 1-phenylcyclopropanecarboxylic acid (1) was reacted with sodium azide and sulfuric acid in chloroform to produce 1-phenylcyclopropanamine (2). Subsequently, 1-phenylcyclopropanamine was reacted with 2-methanesulfonyl chloride in chloroform under alkaline conditions to prepare to obtain the protected derivative (3), i.e., N-(1-phenylcyclopropyl) homotrimethylbenzenesulfonamide. Next, N-(1-phenylcyclopropyl)homotrimethylbenzenesulfonamide (3) was reacted with N-(4-bromobutyl)phthalimide (4) in DMF in the presence of sodium hydride overnight at room temperature to obtain N-(2- homotrimethylbenzenesulfonyl)-N-(1-phenylcyclopropyl)-4-phthalimidobutylamine (5). Then, phthaloyl was removed by reacting N-(2- homotrimethylbenzenesulfonyl)-N-(1-phenylcyclopropyl)-4-phthalimidobutylamine (5) with aniline hydrochloride and sodium methanol in methanol to produce N-(4-aminobutyl)-N-(1-phenylcyclopropyl)-2- homotrimethylbenzenesulfonamide (6). Next, the free amino group was again protected using 2- homotrimethylbenzenesulfonyl chloride in chloroform with hydrogen chloride to give N-(4-(homotrimethylbenzene-2-sulfonylamino)butyl)-N-(1-phenylcyclopropyl)-2- homotrimethylbenzenesulfonamide (7). Subsequently, a derivative of tetra- homotrimethylbenzene-2-sulfonyl-protected 1,2-bis((N-(1-phenylcyclopropyl)-4-aminobutyl)aminomethyl)cyclopropane (8) was prepared by reacting (7) with 1,2-bis(homotrimethylbenzene-2-sulfonyl- protected 1,2-bis((N-(1-phenylcyclopropyl)-4-amino-butyl)aminomethyl)cyclopropane) in DMF, in the presence of sodium hydride, at room temperature, overnight, to obtain (9). Finally, the homotrimethylbenzene-protecting group was removed using HBr in acetic acid and phenol in dichloromethane to give 1,2-bis((N-(1-phenylcyclopropyl)-4-aminobutyl)aminomethyl)cyclopropane (CGC-11255; SL-11255).
References
[1] Patent: WO2006/86773, 2006, A2. Location in patent: Page/Page column 32-34
[2] Patent: WO2011/119704, 2011, A1. Location in patent: Page/Page column 35-36
[3] Synthetic Communications, 1980, vol. 10, # 2, p. 107 - 110
1-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE manufacturers
- Product
- 1-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE 73930-39-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-20