ChemicalBook > CAS DataBase List > 2-FLUOROISONICOTINONITRILE

2-FLUOROISONICOTINONITRILE

Product Name
2-FLUOROISONICOTINONITRILE
CAS No.
3939-14-8
Chemical Name
2-FLUOROISONICOTINONITRILE
Synonyms
4-Cyano-2-fluoroyridine;4-CYANO-2-FLUOROPYRIDINE;2-FLUOROISONICOTINONITRILE;2-Fluoroisonicotinonitrile98%;2-Fluoroisonicotinonitrile 98%;2-fluoro-4-Pyridinecarbonitrile;2-fluoropyridine-4-carbonitrile;4-Pyridinecarbonitrile, 2-fluoro-;4-Cyano-2-fluoropyridine, 97%, 97%;2-FLUOROISONICOTINONITRILE ISO 9001：2015 REACH
CBNumber
CB7837296
Molecular Formula
C6H3FN2
Formula Weight
122.1
MOL File
3939-14-8.mol
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2-FLUOROISONICOTINONITRILE Property

Melting point:
29-34 °C
Boiling point:
204.9±20.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
Flash point:
82 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to lump
pka
-3.79±0.10(Predicted)
color 
White to Almost white
Water Solubility 
Insoluble in water.
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-37/38-41
Safety Statements 
26-36/37
RIDADR 
UN3439
WGK Germany 
1
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
704016
Product name
4-Cyano-2-fluoropyridine
Purity
97%
Packaging
5g
Price
$64.03
Updated
2025/07/31
Sigma-Aldrich
Product number
704016
Product name
4-Cyano-2-fluoropyridine
Purity
97%
Packaging
1g
Price
$22.1
Updated
2023/06/20
TCI Chemical
Product number
C3383
Product name
4-Cyano-2-fluoropyridine
Purity
>99.0%(GC)
Packaging
5g
Price
$64
Updated
2025/07/31
TCI Chemical
Product number
C3383
Product name
4-Cyano-2-fluoropyridine
Purity
>99.0%(GC)
Packaging
25g
Price
$193
Updated
2025/07/31
Usbiological
Product number
276648
Product name
2-Fluoropyridine-4-carbonitrile
Packaging
5g
Price
$359
Updated
2021/12/16
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2-FLUOROISONICOTINONITRILE Chemical Properties,Usage,Production

Uses

4-Cyano-2-fluoropyridine is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Synthesis

33252-30-1

3939-14-8

General procedure for the synthesis of 4-cyano-2-fluoropyridine from 2-chloro-4-cyanopyridine: 2-chloro-4-cyanopyridine (6.0 g, 43.5 mmol), potassium fluoride (7.56 g, 130.3 mmol), and tetrabutylphosphonium bromide (14.8 g, 43.7 mmol) were dissolved in 1-methyl-2-pyrrolidinone (20 mL) and heated to 100° C. The reaction was carried out at 100° C for 18 h. The reaction was carried out in the following manner. C for 18 hours. After completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate (EtOAc). The organic phase was washed sequentially with water and brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford the target product 4-cyano-2-fluoropyridine (2.3 g, 43% yield). The mass spectrum (ES) showed m/z 123.1 ([M + H]+). NMR hydrogen spectrum (400 MHz, CDCl3) δ 8.43 (d, 1H, J = 5.2 Hz), 7.45 (m, 1H), 7.22 (m, 1H).

References

[1] Patent: WO2005/66126, 2005, A1. Location in patent: Page/Page column 60
[2] Patent: WO2010/25451, 2010, A2. Location in patent: Page/Page column 50
[3] Patent: US2011/54173, 2011, A1. Location in patent: Page/Page column 30
[4] Patent: WO2011/25505, 2011, A1. Location in patent: Page/Page column 64
[5] Journal of Organic Chemistry, 2015, vol. 80, # 24, p. 12137 - 12145

2-FLUOROISONICOTINONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-FLUOROISONICOTINONITRILE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-FLUOROISONICOTINONITRILE 3939-14-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25

3939-14-8, 2-FLUOROISONICOTINONITRILERelated Search:

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile 2-Cyano-6-fluoropyridine 3-Cyano-2-fluoropyridine N-Benzyloxycarbonyl-(2S,4R)-2-cyano-4-fluoropyrrolidine 2-Cyano-5-fluoropyridine 5-Cyano-2-fluoropyridine 2-Cyano-3-fluoropyridine 2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE 2-FLUOROISONICOTINONITRILE 2,6-DIFLUORO-4-CYANO-PYRIDINE

  • 4-Cyano-2-fluoropyridine, 2-Fluoropyridine-4-carbonitrile
  • 2-cyano-2-fluoro-1,2-dihydropyridine-4-carboxylic acid
  • 2-fluoro-4-Pyridinecarbonitrile
  • 4-Cyano-2-fluoropyridine, 97%, 97%
  • 2-fluoropyridine-4-carbonitrile
  • 4-Pyridinecarbonitrile, 2-fluoro-
  • 2-FLUOROISONICOTINONITRILE
  • 2-Fluoroisonicotinonitrile 98%
  • 2-Fluoroisonicotinonitrile98%
  • 4-CYANO-2-FLUOROPYRIDINE
  • 4-Cyano-2-fluoroyridine
  • 2-FLUOROISONICOTINONITRILE ISO 9001：2015 REACH
  • 3939-14-8
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