6-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE
- Product Name
- 6-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE
- CAS No.
- 63839-24-7
- Chemical Name
- 6-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE
- Synonyms
- 1H-Indole, 6-broMo-2,3-dihydro-;6-BROMO-2,3-DIHYDRO-1H-INDOLE HCL;6-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE;6-Bromoindoline , 6-Bromo-2,3-dihydro-1H-indole;6-Bromoindoline 6-BROMO-2,3-DIHYDRO-1H-INDOLE in stock Factory
- CBNumber
- CB7840427
- Molecular Formula
- C8H8BrN
- Formula Weight
- 198.06
- MOL File
- 63839-24-7.mol
6-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE Property
- Boiling point:
- 116-118 °C(Press: 4 Torr)
- Density
- 1.514±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 4.28±0.20(Predicted)
- Appearance
- Off-white to pale purple Solid
Safety
- Hazard Codes
- T
- Risk Statements
- 25-51/53-36/37/38
- Safety Statements
- 45-61-36-26
- RIDADR
- UN2811
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B700520
- Product name
- 6-Bromoindoline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB52114
- Product name
- 6-Bromo-2,3-dihydro-1H-indole
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FB52114
- Product name
- 6-Bromo-2,3-dihydro-1H-indole
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 119366
- Product name
- 6-Bromoindoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- FB52114
- Product name
- 6-Bromo-2,3-dihydro-1H-indole
- Packaging
- 2g
- Price
- $188
- Updated
- 2021/12/16
6-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE Chemical Properties,Usage,Production
Chemical Properties
White to off-white to light brown powder
Synthesis
52415-29-9
63839-24-7
Step 1: Synthesis of 6-bromo-2,3-dihydro-1H-indole To a mixed solution of 6-bromo-1H-indole (11.0 g, 56.1 mmol) in dichloromethane (180 mL) and trifluoroacetic acid (60 mL) was added triethylsilane (22.6 mL, 2.5 equiv). The reaction mixture was stirred at room temperature for 16 hours. Subsequently, additional dichloromethane (180 mL), concentrated ammonium hydroxide solution (about 50 mL) and water (200 mL) were added. The mixture was extracted with dichloromethane, the organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was redissolved in a solvent mixture of ether and hexane (1:1, 100 mL), and a dioxane solution of 4N HCl (14 mL) was slowly added, and a precipitate was immediately observed to form. The precipitate was collected by filtration and the resulting solid was treated with saturated sodium bicarbonate solution. The mixture was again extracted with dichloromethane, the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 6-bromo-2,3-dihydro-1H-indole as a brown oil (ca. 10.0 g), which was used directly in the subsequent reaction without further purification.LC-MS analysis: m/z 195.9/197.9 [M-H]+, retention time 0.98 min.
References
[1] ChemMedChem, 2016, vol. 11, # 23, p. 2607 - 2620
[2] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 5, p. 373 - 377
[3] Patent: WO2016/25932, 2016, A1. Location in patent: Page/Page column 144
[4] Journal of Organic Chemistry, 2018, vol. 83, # 4, p. 2425 - 2437
[5] Organic and Biomolecular Chemistry, 2018, vol. 16, # 32, p. 5889 - 5898
6-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
6-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE Suppliers
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View Lastest Price from 6-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE manufacturers
- Product
- 6-Bromoindoline 63839-24-7
- Price
- US $0.10-10.00/KG
- Min. Order
- 0.1KG
- Purity
- 98%
- Supply Ability
- 200TONS
- Release date
- 2025-08-15
- Product
- 6-Bromoindoline 63839-24-7
- Price
- US $22.00-88.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2025-06-25
- Product
- 6-Bromoindoline 6-BROMO-2,3-DIHYDRO-1H-INDOLE in stock Factory 63839-24-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 production capacity Factory
- Release date
- 2019-04-03