ChemicalBook > CAS DataBase List > 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

Product Name
1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
CAS No.
105628-72-6
Chemical Name
1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
Synonyms
Ha 1100;Fasudil Impurity L;Fasudil Impurity 5;1-[(1,2-DIHYDRO-1-OX;HA 1100 HYDROCHLORIDE;HA-1100;HA 1100;HA1100;Hydroxyfasudil, 10 mM in DMSO;HYDROXYFASUDIL;HA-1100;HA 1100;HA1100;5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol;5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one
CBNumber
CB7847446
Molecular Formula
C14H17N3O3S
Formula Weight
307.37
MOL File
105628-72-6.mol
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1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Property

storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to off-white
InChI
InChI=1S/C14H17N3O3S/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17/h1,3-5,7,15H,2,6,8-10H2,(H,16,18)
InChIKey
ZAVGJDAFCZAWSZ-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C(S(N3CCCNCC3)(=O)=O)=CC=C2)C=CN1
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Safety

Toxicity
mouse,LD50,unreported,145mg/kg (145mg/kg),United States Patent Document. Vol. #4678783,
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
2415
Product name
HA1100hydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$244
Updated
2021/12/16
Usbiological
Product number
255432
Product name
HA 1100 hydrochloride
Packaging
10mg
Price
$516
Updated
2021/12/16
ApexBio Technology
Product number
A3478
Product name
Hydroxyfasudil
Packaging
10mg
Price
$126
Updated
2021/12/16
ChemScene
Product number
CS-1599
Product name
Hydroxyfasudil
Purity
98.11%
Packaging
10mg
Price
$136
Updated
2021/12/16
AK Scientific
Product number
3044AH
Product name
1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine
Packaging
5mg
Price
$258
Updated
2021/12/16
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1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Chemical Properties,Usage,Production

Biological Activity

Cell-permeable active metabolite of Fasudil (HA 1077; Fasudil hydrochloride). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo .

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Suppliers

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View Lastest Price from 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE manufacturers

Career Henan Chemical Co
Product
1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE 105628-72-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

105628-72-6, 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINERelated Search:

5-Quinolinesulfonic acid, 2-methyl- Fasudil Impurity 6 Fasudil Impurity 13 Fasudil Pyridine N-Oxide TFA Salt Fasudil Impurity 9 Fasudil Impurity 34 Fasudil iMpurity Fasudil Impurity 7 1-[(1-Chloro-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Fasudil Impurity 8 1-Chloro-5-isoquinolinesulfonic Acid Fasudil Impurity 6 1,4-ditosyl-1,4-diazepane Fasudil diMer Fasudil N-hydroxy iMpurity N-(3-HYDROXYPROPYL)ETHYLENEDIAMINE Isoquinoline HYDROXYFASUDIL MONOHYDROCHLORIDE

  • 5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one
  • HYDROXYFASUDIL;HA-1100;HA 1100;HA1100
  • 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
  • 1H-1,4-Diazepine, hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-
  • Ha 1100
  • Hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-1H-1,4-diazepine
  • 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepinehydrochloride
  • 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol
  • Fasudil Impurity L
  • HA 1100 HYDROCHLORIDE
  • 1-[(1,2-DIHYDRO-1-OX
  • 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one
  • Fasudil impurity 12/5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one hydrochloride
  • HA-1100;HA 1100;HA1100
  • 1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-
  • 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1(8aH)-one
  • HA1100,ROCK,Rho-kinase,inhibit,Rho-associated kinase,Inhibitor,ROK,Hydroxyfasudil,HA 1100,Rho-associated protein kinase
  • Fasudil Impurity 5
  • Hydroxyfasudil, 10 mM in DMSO
  • 105628-72-6
  • C14H17N3O3S
  • Angiogenesis and Metastasis
  • Intracellular signaling