ChemicalBook > CAS DataBase List > 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

Product Name
1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
CAS No.
105628-72-6
Chemical Name
1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
Synonyms
Ha 1100;Fasudil Impurity L;Fasudil Impurity 5;1-[(1,2-DIHYDRO-1-OX;HA 1100 HYDROCHLORIDE;HA-1100;HA 1100;HA1100;HYDROXYFASUDIL;HA-1100;HA 1100;HA1100;5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol;5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one;5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1(8aH)-one
CBNumber
CB7847446
Molecular Formula
C14H17N3O3S
Formula Weight
307.37
MOL File
105628-72-6.mol
More
Less

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Property

storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to off-white
More
Less

Safety

Toxicity
mouse,LD50,unreported,145mg/kg (145mg/kg),United States Patent Document. Vol. #4678783,
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Tocris
Product number
2415
Product name
HA1100hydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$244
Updated
2021/12/16
Usbiological
Product number
255432
Product name
HA 1100 hydrochloride
Packaging
10mg
Price
$516
Updated
2021/12/16
AK Scientific
Product number
3044AH
Product name
1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine
Packaging
5mg
Price
$258
Updated
2021/12/16
ApexBio Technology
Product number
A3478
Product name
Hydroxyfasudil
Packaging
10mg
Price
$126
Updated
2021/12/16
ChemScene
Product number
CS-1599
Product name
Hydroxyfasudil
Purity
98.11%
Packaging
10mg
Price
$136
Updated
2021/12/16
More
Less

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Chemical Properties,Usage,Production

Biological Activity

Cell-permeable active metabolite of Fasudil (HA 1077; Fasudil hydrochloride). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo .

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Suppliers

China 63 Germany 1 South Korea 1 Switzerland 1 United Kingdom 1 United States 16 Global 83
AXXORA, LLC
Tel
--
Fax
--
Email
alexis-ch@alexis-corp.com
Country
Switzerland
ProdList
1104
Advantage
80
More
Less

View Lastest Price from 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE manufacturers

Career Henan Chemical Co
Product
1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE 105628-72-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

105628-72-6, 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINERelated Search:

5-Quinolinesulfonic acid, 2-methyl- Fasudil Impurity 6 Fasudil Impurity 13 Fasudil Pyridine N-Oxide TFA Salt Fasudil Impurity 9 Fasudil Impurity 34 Fasudil iMpurity Fasudil Impurity 7 1-[(1-Chloro-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Fasudil Impurity 8 1-Chloro-5-isoquinolinesulfonic Acid Fasudil Impurity 6 1,4-ditosyl-1,4-diazepane Fasudil diMer Fasudil N-hydroxy iMpurity N-(3-HYDROXYPROPYL)ETHYLENEDIAMINE Isoquinoline HYDROXYFASUDIL MONOHYDROCHLORIDE

  • 5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one
  • HYDROXYFASUDIL;HA-1100;HA 1100;HA1100
  • 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
  • 1H-1,4-Diazepine, hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-
  • Ha 1100
  • Hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-1H-1,4-diazepine
  • 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepinehydrochloride
  • 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol
  • Fasudil Impurity L
  • HA 1100 HYDROCHLORIDE
  • 1-[(1,2-DIHYDRO-1-OX
  • 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one
  • Fasudil impurity 12/5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one hydrochloride
  • HA-1100;HA 1100;HA1100
  • 1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-
  • 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1(8aH)-one
  • HA1100,ROCK,Rho-kinase,inhibit,Rho-associated kinase,Inhibitor,ROK,Hydroxyfasudil,HA 1100,Rho-associated protein kinase
  • Fasudil Impurity 5
  • 105628-72-6
  • C14H17N3O3S
  • Angiogenesis and Metastasis
  • Intracellular signaling