ChemicalBook > CAS DataBase List > (R)-(-)-2-Amino-1-propanol

(R)-(-)-2-Amino-1-propanol

Product Name
(R)-(-)-2-Amino-1-propanol
CAS No.
35320-23-1
Chemical Name
(R)-(-)-2-Amino-1-propanol
Synonyms
(R)-1-Aminopropan-2-ol;D-ALANINOL;(R)-2-AMINO-1-PROPANOL;(2R)-2-AMINO-1-PROPANOL;D-ALAOH;2-AMINO PROPANOL;(2R)-2-Aminopropan-1-ol;D-Ala-ol;D-Alaniol;H-D-ALA-OL
CBNumber
CB7853542
Molecular Formula
C3H9NO
Formula Weight
75.11
MOL File
35320-23-1.mol
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(R)-(-)-2-Amino-1-propanol Property

Melting point:
8 °C
Boiling point:
173-176 °C(lit.)
alpha 
-17 º (c=neat)
Density 
0.965
refractive index 
n20/D 1.450(lit.)
Flash point:
183 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Oily Liquid
pka
12.88±0.10(Predicted)
color 
Clear colorless to light yellow
Specific Gravity
0.965
optical activity
[α]19/D 18°, neat
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
BRN 
1718866
CAS DataBase Reference
35320-23-1(CAS DataBase Reference)
NIST Chemistry Reference
(R)-(-)-2-Amino-1-propanol(35320-23-1)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-36/37/38
Safety Statements 
26-36/37/39-45-36
RIDADR 
UN 2735 8/PG 2
WGK Germany 
3
F 
10-23
Hazard Note 
Corrosive/Hygroscopic
HazardClass 
8
PackingGroup 
III
HS Code 
29221990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
297682
Product name
(R)-(?)-2-Amino-1-propanol
Purity
98%
Packaging
1g
Price
$25.92
Updated
2024/03/01
Sigma-Aldrich
Product number
297682
Product name
(R)-(?)-2-Amino-1-propanol
Purity
98%
Packaging
5g
Price
$132
Updated
2023/06/20
TCI Chemical
Product number
A2002
Product name
(R)-(-)-2-Amino-1-propanol
Purity
>98.0%(GC)(T)
Packaging
5mL
Price
$86
Updated
2025/07/31
TCI Chemical
Product number
A2002
Product name
(R)-(-)-2-Amino-1-propanol
Purity
>98.0%(GC)(T)
Packaging
25mL
Price
$254
Updated
2025/07/31
TRC
Product number
A628145
Product name
(R)-(-)-2-Amino-1-propanol
Packaging
2.5g
Price
$55
Updated
2021/12/16
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(R)-(-)-2-Amino-1-propanol Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

(R)-(-)-2-Amino-1-propanol has been used as a derivatizing agent for gossypol during the analysis of gossypol enantiomers in cottonseed by high-performance liquid chromatography.

Application

R)-(-)-2-Amino-1-propanol is used as a chiral intermediate for the synthesis of pharmaceutical products and agrochemicals. It acts as additives in health care products and animal feed. It is a amino alcohol obtained by reduction of d-alanine. This compound could be converted into the corresponding nonracemic adenine derivative (R)-9-(1-Methyl-2-hydroxyethyl)adenine through minor variations on the classic Montgomery sequence[1].

General Description

(R)-(-)-2-Amino-1-propanol is a chiral secondary amine.

Synthesis

338-69-2

35320-23-1

General procedure for the synthesis of (R)-2-aminopropan-1-ol from D-alanine: The present embodiment relates to the synthesis of a class of intermediates of long-chain ethylpiperazine sulfonamide derivatives, in particular the preparation of (R)-2-aminopropan-1-ol. 150 mL of anhydrous THF and 1.1 g of LiAlH4 (29 mmol) were added to a dry three-necked flask and the reaction system was cooled to 0 °C. Subsequently, 4.9 g of D-alanine (55.0 mmol) was added to the reactor in batches, and the addition process lasted for 30 min. After the addition was completed, stirring was continued at 0 °C for 2 h. Then the temperature was gradually increased to reflux and the reflux reaction was maintained for 16 h. The reaction system was then cooled to 0 °C for 2 h. Upon completion of the reaction, the reaction system was cooled in an ice bath, and 100 mL of ether, 4.5 mL of water, 4.5 mL of 15% NaOH solution, and 12 mL of water were added slowly in sequence to quench the reaction. The reaction mixture was filtered through diatomaceous earth and the filtrate was collected. The filtrate was concentrated under reduced pressure to remove the solvent to give the crude product. The crude product was purified by silica gel column chromatography with the eluent of dichloromethane:ethanol=10:1 (v/v), resulting in 3.41 g of colorless oily product in 82.5% yield.

References

[1] Jeffery A, et al. Synthesis of Acyclic Nucleoside and Nucleotide Analogues from Amino Acids: A Convenient Approach to a PMEA±PMPA Hybrid. Tetrahedron, 2000; 56: 5077-5083.

(R)-(-)-2-Amino-1-propanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(-)-2-Amino-1-propanol Suppliers

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View Lastest Price from (R)-(-)-2-Amino-1-propanol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
(R)-(-)-2-Amino-1-propanol 35320-23-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-27
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
(R)-(-)-2-Amino-1-propanol 35320-23-1
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
5 MTs
Release date
2024-05-10
R&D Scientific Inc.
Product
(R)-2-Aminopropan-1-ol 35320-23-1
Price
US $590.00/Kg
Min. Order
0.100Kg
Purity
98
Supply Ability
5000 Kg
Release date
2025-03-06

35320-23-1, (R)-(-)-2-Amino-1-propanolRelated Search:

DIETHYL FORMAMIDOMALONATE TRANS-2-AMINOCYCLOHEXANOL HYDROCHLORIDE N-ALPHA-BENZOYL-L-ARGININE DL-3-(4-Fluorophenyl)alanine CHLOROACETYL-L-TYROSINE BIS-Tris 1-Amino-1-cyclohexanecarboxylic acid Nalpha-Cbz-L-Arginine D-Cystine Cycloleucine (-)-Pseudoephedrine N-Cbz-L-Serine 3-(3-Hydroxyphenyl)-DL-alanine Liothyronine sodium Sodium levothyroxine Z-AIB-OH Methyldopa Levothyroxine

  • D-Alaninol, 98%, ee: 98%
  • (R)-(-)-2-AMINOPROPANOL
  • (R)-(-)-2-AMINO-1-PROPANOL
  • (R)-2-AMINO-1-PROPANOL
  • H-D-ALA-OL
  • H-D-ALANINOL
  • H-DL-ALA-OL
  • D-ALAOH
  • D-(-)-ALANINOL
  • D-ALANINOL
  • D-2-AMINO-PROPANOL
  • D-Alaninol, ee: 97%
  • D - aMino propanol
  • (<i>R</i>)-(-)-2-Amino-1-propanol
  • (R)-(-)-2-AMino-1-propanol 98%
  • (R)-(-)-2-AMino-1-propanol, 99.8%+
  • D-Alaninol≥ 99% (GC)
  • (2R)-2-AMINO-1-PROPANOL
  • (+/-)-2-AMINO-1-PROPANOL
  • 2-AMINO PROPANOL
  • DL-2-AMINOPROPYL-ALCOHOL
  • DL-2-AMINO PROPANOL
  • DL-ALANILOL
  • (R)-1-Aminopropan-2-ol
  • D-ALANINOL / (R)-(-)-2-AMINO-1-PROPANOL
  • D-amine propionic acid
  • D-Alaniol-(R)-(-)-2-Amino-1-Propanol
  • D-Alaniol
  • R(-)-2-AMINO-1-PROPANOL-13C3 (D-ALANINOL
  • D-Alaninol98%
  • D-Ala-ol
  • 1-PROPANOL, 2-AMINO-, (2R)-
  • D-Alaninol ,98% [ee: 97%]
  • D-Alanilol
  • (2R)-2-Amino-1-hydroxypropane, D-Alaninol
  • (2R)-2-Aminopropan-1-ol
  • [(R)-1-Methyl-2-hydroxyethyl]amine
  • (R)-(-)-2-Amino-1-propanol,98%
  • (R)-(-)-2-Amino-1-propanol &gt
  • (R)-(-)-2-Amino-1-propanol USP/EP/BP
  • D-Alaninol, 98% [(R)-(-)-2-Amino-1-propanol]
  • (D)-2-Alaninol
  • 35320-23-1
  • 5320-23-1
  • CH3CHNH2CH2OH
  • AMINE
  • Amino Alcohols
  • Alphabetical Listings
  • Amino Acid Derivatives
  • BioChemical
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Specialty Synthesis
  • Peptide Synthesis
  • Stable Isotopes
  • Organic Building Blocks
  • Alanine [Ala, A]
  • Amino Alcohols (Chiral)