Neostigmine Methyl Sulfate

Product Name: Neostigmine Methyl Sulfate
CAS No.: 51-60-5
Chemical Name: Neostigmine Methyl Sulfate
Synonyms: NEOSTIGMINE METHYL SULPHATE;neostigmine metilsulfate;hodostin;vagostigmin;NEOSTIGIMINE BROMIDE;3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZAMINIUM BROMIDE;GD-65;ar-32;sb-23;Stiglyn
CBNumber: CB7853724
Molecular Formula: C12H19N2O2.CH3O4S
Formula Weight: 334.39
MOL File: 51-60-5.mol

More

Less

Neostigmine Methyl Sulfate Property

Melting point:: 175-177 °C(lit.)
storage temp.: -20°C
solubility: H₂O: 1 g/mL
form: powder
color: white
Water Solubility: 1g/10mL
Merck: 14,6464
CAS DataBase Reference: 51-60-5(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: T+
Risk Statements: 28-36/37/38-42/43-26/27/28
Safety Statements: 36-45-36/37/39-28A
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: CY1225000
HazardClass: 6.1(a)
PackingGroup: II
HS Code: 29242990
Toxicity: LD50 in mice (mg/kg): 0.16 i.v.; 0.42 s.c.; 7.5 orally, (Randall, Lehmann)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N2126
Product name: Neostigmine methyl sulfate
Packaging: 1g
Price: $58.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1460000
Product name: Neostigmine methyl sulfate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: N0447
Product name: Neostigmine Methyl Sulfate
Purity: >98.0%(N)
Packaging: 5g
Price: $113
Updated: 2024/03/01

TCI Chemical

Product number: N0447
Product name: Neostigmine Methyl Sulfate
Purity: >98.0%(N)
Packaging: 25g
Price: $410
Updated: 2024/03/01

Cayman Chemical

Product number: 23501
Product name: Neostigmine (methyl sulfate)
Purity: ≥98%
Packaging: 500mg
Price: $32
Updated: 2024/03/01

More

Less

Neostigmine Methyl Sulfate Chemical Properties,Usage,Production

Description

Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE; K_d = 260 μM). In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 μg) increases endogenous acetylcholine levels and dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED₅₀s = 6.6 and 3.5 μg, respectively). Neostigmine (5 μg, i.p.) restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block. Formulations containing neostigmine have been used in the treatment of myasthenia gravis and Ogilvie syndrome.

Chemical Properties

Crystalline Solid

Uses

Cholinergic; miotic; antidote (curare)

Definition

ChEBI: Neostigmine methyl sulfate is an arylammonium sulfate salt. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor.

brand name

Prostigmine (ICN).

General Description

Neostigmine methylsulfate,(m-hydroxyphenyl)trimethylammonium methylsulfatedimethylcarbamate or the dimethylcarbamic ester of 3-hydroxyphenyltrimethylammoniummethylsulfate (Prostigminmethylsulfate), is a bitter, odorless, white, crystalline powder.It is very soluble in water and soluble in alcohol. Solutionsare stable and can be sterilized by boiling. The compound istoo hygroscopic for use in a solid form and thus is alwaysused as an injection. Aqueous solutions are neutral to litmus.

Clinical Use

The methylsulfate salt is used postoperatively as a urinarystimulant and in the diagnosis and treatment of myastheniagravis.

Purification Methods

Crystallise the sulfate from EtOH or Me2CO (m 143-144o). Its solubility in H2O is ~10%. [Beilstein 13 III 939.] (It is cholinergic and highly TOXIC.)

Neostigmine Methyl Sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Neostigmine Methyl Sulfate Suppliers

Americas 1 Australia 1 Austria 1 Belgium 3 Brazil 1 Canada 3 China 258 Europe 1 France 2 Germany 6 India 41 Japan 6 Slovakia 1 Spain 1 Switzerland 3 The Netherlands 1 United Arab Emirates 1 United Kingdom 14 United States 52 Venezuela 1 Global 398

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Apin Chemicals Limited (UK)

Tel: --
Fax: --
Email: info@apinchemicals.com
Country: United Kingdom
ProdList: 6184
Advantage: 60

Long-Range Europe Limited

Tel: --
Fax: --
Email: info@long-range.co.uk
Country: United Kingdom
ProdList: 425
Advantage: 58

Biosynth Carbosynth

Tel: --
Fax: --
Email: ales@carbosynth.com
Country: United Kingdom
ProdList: 2598
Advantage: 58

Molekula Limited

Tel: --
Fax: --
Email: o@molekula.com
Country: United Kingdom
ProdList: 6127
Advantage: 58

Whyte Chemicals

Tel: --
Fax: --
Email: sales@whytechemicals.co.uk
Country: United Kingdom
ProdList: 3748
Advantage: 50

Leancare Ltd.

Tel: --
Fax: --
Email: enquiry@leancare.co.uk
Country: United Kingdom
ProdList: 6446
Advantage: 42

MOLEKULA Ltd.

Tel: --
Fax: --
Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
Advantage: 66

CARBONE SCIENTIFIC CO.,LTD

Tel: --
Fax: --
Email: sales@carbonesci.com
Country: United Kingdom
ProdList: 6666
Advantage: 30

Eurolabs Limited

Tel: --
Fax: --
Country: United Kingdom
ProdList: 6309
Advantage: 46

UK GREEN SCIENTIFIC CO.,LIMITED

Tel: --
Fax: --
Email: sales@gs-chem.com
Country: United Kingdom
ProdList: 6098
Advantage: 47

Sequoia Research Products Ltd.

Tel: --
Fax: --
Email: sales@seqchem.com
Country: United Kingdom
ProdList: 3113
Advantage: 69

Apin Chemicals Ltd.

Tel: --
Fax: --
Email: info@apinchemicals.com
Country: United Kingdom
ProdList: 6807
Advantage: 42

VWR International

Tel: --
Fax: --
Email: solutions@vwr.com
Country: United Kingdom
ProdList: 6548
Advantage: 82

More

Less

View Lastest Price from Neostigmine Methyl Sulfate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Neostigmine Methyl Sulfate 51-60-5
Price: US $0.00/KG
Min. Order: 10g
Purity: 99%min
Supply Ability: 10kg
Release date: 2021-11-18

Dideu Industries Group Limited

Product: Neostigmine Methyl Sulfate 51-60-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-27

Zhuozhou Wenxi import and Export Co., Ltd

Product: Neostigmine Methyl Sulfate 51-60-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

51-60-5, Neostigmine Methyl SulfateRelated Search:

Ammonium bisulfite Tetramethylammonium hydroxide pentahydrate PHENYLTRIMETHYLAMMONIUM METHOSULFATE DIMETHYLAMMONIUM DIMETHYLCARBAMATE(DIMCARB) AMMONIUM CARBAMATE 3-METHOXY-N-METHYLANILINE Neostigmine Methyl Sulfate Ammonium sulfate Sulfuric acid Ammonium bisulfate 3-Dimethylaminophenol Tetramethylammonium hydrogen sulfate 3-dimethylaminophenyl dimethylcarbamate 3-Dimethylaminoanisole PHENYLTRIMETHYLAMMONIUM HYDROXIDE 3-AMINOPHENYL N,N-DIMETHYLCARBAMATE, 97 Phenyl carbamate Ammonium Sulfite

A sulfuric acid neostigmine

(3-(dimethylcarbamoyloxy)phenyl)trimethyl-ammoniumethylsulfate

(3-hydroxyphenyl)trimethylammoniummethylsulfatedimethylcarbamicester

(m-hydroxyphenyl)trimethylammoniummethylsulfatedimethylcarbamate

PROSTIGMINE

NEOSTIGIMINE BROMIDE

NEOSTIGMINE METHYL SULFATE

NEOSTIGMINE METHYL SULPHATE

3-[N,N-DIMETHYLCARBAMOYLOXY]-N,N,N-TRIMETHYLANILINIUM METHYL SULFATE

(3-HYDROXYPHENYL)TRIMETHYLAMMONIUM BROMIDE DIMETHYL CARBAMATE

(3-HYDROXYPHENYL)TRIMETHYLAMMONIUM METHYL SULFATE DIMETHYLCARBAMATE

3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZAMINIUM BROMIDE

3-[([DIMETHYLAMINO]CARBONYL)OXY]-N,N,N-TRIMETHYLBENZAMINIUM METHYL SULFATE

3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZENAMINIUM BROMIDE

3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZENAMINIUM METHYL SULFATE

(3-DIMETHYLCARBAMOYLOXYPHENYL)TRIMETHYLAMMONIUM BROMIDE

(3-DIMETHYLCARBAMOYLOXYPHENYL)TRIMETHYLAMMONIUM METHYL SULFATE

neostigmine metilsulfate

Intrastigmina

Metastigmin

Stiglyn

NEOSTIGMINE METHYL SULPHATE(RG)

Ethyl N-[2-[4-(phenoxy)phenoxy]ethyl]carbamate

Phenoxycarb

GD-65

3-(((dimethylamino)carbonyl)oxy)-n,n,n-trimethyl-benzenaminiumethylsulfat

3-(dimethylcarbamoxy)phenyltrimethylammoniummethylsulfate

ammonium,(m-hydroxyphenyl)trimethyl-,methylsulfate,dimethylcarbamate

Ammonium,[3-(dimethylcarbamoyloxy)phenyl]trimethyl-,methylsulfate

ar-32

Benzenaminium,3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-,methylsulfate

carbamicacid,n,n-dimethyl-,3-(trimethylammonio)phenylester,methylsulfate

carbamicacid,n,n-dimethyl-,3-dimethylaminophenylester,methosulfate

dimethyl-carbamicaciesterwith(m-hydroxyphenyl)trimethylammoniummethy

dimethylcarbamicesterof3-oxyphenyltrimethylammoniummethylsulfate

eustigminmethylsulfate

hodostin

kirkstigminemethylsulfate

leostigminemethylsulfate

neoeserinemethylsulfate

neostigmeth

neostigminemethosulfate

neostigminemonomethylsulfate

normastigmin

philostigminmethylsulfate

polstigmine

proserin

proserinemethylsulfate

prostigminemethylsulfate

prostigminmethylsulfate

sb-23

stigmanolmethylsulfate

stigmosanmethylsulfate

synstigmine

syntostigmin

syntostigmin(injection)

syntostigmine

tl-1394