1,2,4,5-Tetrachlorobenzene Property

Melting point:

139 °C

Boiling point:

240-246 °C(lit.)

Density 

1.858

vapor pressure 

5 at 25 °C (extrapolated, Mackay et al., 1982)

refractive index 

1.5348 (estimate)

Flash point:

>230 °F

storage temp. 

0-6°C

solubility 

0.0003g/l

form 

Crystalline Solid

color 

Light pink to gray

Water Solubility 

insoluble. <0.1 g/100 mL at 21 ºC

BRN 

1618315

Henry's Law Constant

0.10 at 20 °C (gas stripping-GC, Oliver, 1985)

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents. Reacts explosively with alkaline methanol solutions.

CAS DataBase Reference

95-94-3(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1,2,4,5-tetrachloro-(95-94-3)

EPA Substance Registry System

1,2,4,5-Tetrachlorobenzene (95-94-3)

Safety

Hazard Codes 

Xn,T,F,N

Risk Statements 

22-36/37/38-23/24/25-11-36-20/21/22-51/53

Safety Statements 

26-36-45-27-16-36/37-61

RIDADR 

UN 3077 9/PG 3

WGK Germany 

3

RTECS 

DB9450000

TSCA 

Yes

HazardClass 

9

HS Code 

29036990

Hazardous Substances Data

95-94-3(Hazardous Substances Data)

Toxicity

Acute oral LD50 for rats 1,500 mg/kg, mice 1,035 mg/kg (quoted, RTECS, 1985).

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

1,2,4,5-Tetrachlorobenzene Chemical Properties,Usage,Production

Chemical Properties

white solid

Uses

Intermediate for herbicides and defoliants, insecticide, impregnant for moisture resistance, electrical insulation.

Uses

1,2,4,5-Tetrachlorobenzene was used to study the environmental behavior of hexachlorobutadiene (HCBD).

Definition

ChEBI: A tetrachlorobenzene carrying chloro groups at positions 1, 2, 4 and 5.

Environmental Fate

Biological. A mixed culture of soil bacteria or a Pseudomonas sp. transformed 1,2,4,5- tetrachlorobenzene to 2,3,5,6-tetrachlorophenol (Ballschiter and Scholz, 1980). After incubation in sewage sludge for 32 d under anaerobic conditions, 1,2,4,5-tetrachlorobenzene did not biodegrade (Kirk et al., 1989).
In an enrichment culture derived from a contaminated site in Bayou d’Inde, LA, 1,2,4,5- tetrachlorobenzene underwent reductive dechlorination to 1,2,4-trichlorobenzene. The maximum dechlorination rate, based on the recommended Michaelis-Menten model, was 5.5 nM/d (Pavlostathis and Prytula, 2000).
Photolytic. Irradiation (λ ≥285 nm) of 1,2,4,5-tetrachlorobenzene (1.1–1.2 mM/L) in an acetonitrile-water mixture containing acetone (0.553 mM) as a sensitizer gave the following products (% yield): 1,2,4-trichlorobenzene (25.3), 1,3-dichlorobenzene (8.1), 1,4-dichlorobenzene (3.6), 2,2′,3,4′,5,5′,6-heptachlorobiphenyl (4.19), four hexachlorobiphenyls (6.78), four pentachlorobiphenyls (2.33), one tetrachlorobiphenyl (0.32), 2,4,5-trichloroacetophenone, and (2,4,5- trichlorophenyl)acetonitrile (Choudhry and Hutzinger, 1984). Without acetone, the identified photolysis products (% yield) included 1,2,4-trichlorobenzene (27.7), 1,3-dichlorobenzene (0.3), 1,4-dichlorobenzene (8.5), pentachlorobenzene (trace), 1,2,3,4-tetrachlorobenzene (0.45), 1,2,3,5- tetrachlorobenzene (1.11), 2,2′,3,4′,5,5′,6-heptahlorobiphenyl (1.24), three hexachlorobiphenyls (1.19), and four pentachlorobiphenyls (0.56) (Choudhry and Hutzinger, 1984). The sunlight irradiation of 1,2,4,5-tetrachlorobenzene (20 g) in a 100-mL borosilicate glass-stoppered Erlenmeyer flask for 28 d yielded 26 ppm heptachlorobiphenyl (Uyeta et al., 1976).
Chemical/Physical. Based on an assumed base-mediated 1% disappearance after 16 d at 85 °C and pH 9.70 (pH 11.26 at °C), the hydrolysis half-life was estimated to be >900 yr (Ellington et al., 1988).

Purification Methods

Crystallise it from EtOH, ether, *benzene, *benzene/EtOH or carbon disulfide. [Beilstein 5 IV 668.]