Moguisteine
- Product Name
- Moguisteine
- CAS No.
- 119637-67-1
- Chemical Name
- Moguisteine
- Synonyms
- BBR-2173;moguisteine;MOGUISTEINE(FORR&DONLY);Moguisteine, 10 mM in DMSO;2-(2-METHOXYPHENOXY)METHYL-1,3-THIAZOLIDINE;ethyl 3-(2-((2-methoxyphenoxy)methyl)thiazolidin-3-yl)-3-oxopropanoate;(+/-)-2-(2-methoxyphenoxy)-methyl-3-ethoxycarbonylacetyl-1,3-thiazolidine;(r,s)-2-(2-methoxyphenoxy)-methyl-3-ethoxycarbonyl-acetyl-1,3 thiazolidine;ethyl 3-[2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidin-3-yl]-3-oxopropanoate;ethyl 3-[2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidin-3-yl]-3-oxo-propanoate
- CBNumber
- CB7855425
- Molecular Formula
- C16H21NO5S
- Formula Weight
- 339.41
- MOL File
- 119637-67-1.mol
Moguisteine Property
- Melting point:
- 72-76°C
- Boiling point:
- 506.8±50.0 °C(Predicted)
- Density
- 1.225±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.49±0.40(Predicted)
- color
- White to Off-White
- CAS DataBase Reference
- 119637-67-1(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- M3305
- Product name
- Moguisteine
- Packaging
- 250MG
- Price
- $49
- Updated
- 2025/07/31
- Product number
- M3305
- Product name
- Moguisteine
- Packaging
- 1G
- Price
- $133
- Updated
- 2025/07/31
- Product number
- 30362
- Product name
- Moguisteine
- Packaging
- 250mg
- Price
- $66
- Updated
- 2024/03/01
- Product number
- 30362
- Product name
- Moguisteine
- Packaging
- 5g
- Price
- $606
- Updated
- 2024/03/01
- Product number
- 30362
- Product name
- Moguisteine
- Packaging
- 100mg
- Price
- $32
- Updated
- 2024/03/01
Moguisteine Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
antitussive, non-narcotic
Uses
An antitussive with properties similar to codeine
Uses
Peripherally acting antitussive.
Synthesis
6148-64-7
103181-68-6
119637-67-1
Crude thiazolidine (50.0 g, 0.222 mol), triazole 1-hydroxybenzoate hydrate (0.5 g) and acetone part I (197.8 ml) of Example 33 were added to a 1 L flask under nitrogen protection and stirred at room temperature. The suspension was cooled to 0 °C ± 5 °C and concentrated hydrochloric acid (24.5 ml, 33.0%) was added slowly and dropwise over a period of about 1 h during which an exothermic reaction was observed and the temperature was raised to 18 °C - 20 °C. Meanwhile, a solution of N,N'-dicyclohexylcarbodiimide (51.25 g, 0.244 mol) was prepared in acetone (197.8 ml) in a separate vessel avoiding contact with water . When the temperature of the suspension was stabilized at 0°C ± 5°C, the DCC solution was slowly added dropwise for not less than 3 hours. After the dropwise addition, the reaction mixture was stirred at 0°C ± 5°C for 2 hours. After confirming the completion of the reaction by TLC, N,N'-dicyclohexylurea (DCU) was removed by filtration and washed with acetone (140.0 ml) and the washings were combined into the main filtrate. The combined filtrates were concentrated under reduced pressure to about 300 ml at 50°C ± 5°C and allowed to stand overnight. The dark yellow solution obtained was treated with activated carbon (5.0 g) for 10 min and then filtered through a diatomaceous earth plate to obtain a clarified yellow solution. The filter was washed with acetone (80 ml) and the washings were combined with the main filtrate (totaling about 380 ml). The acetone solution of moguisteine was cooled to 0°C ± 5°C and precipitated by slow addition of deionized water (380 ml), during which the moguisteine crystals were added. after 15-30 min, the product precipitated as an oily colloid and gradually crystallized. After crystallization was complete, the remaining deionized water (76 ml, total 456 ml, acetone/water ratio 1.0:1.2) was added. The suspension was kept at 0°C ± 5°C for at least 8 hours, followed by stirring at room temperature overnight. The product was collected by filtration and washed with deionized water (2 x 100 ml) to give 94.4 g of near white product. The product was dried at 35°C ± 5°C to give 69.5 g of white to pale yellow powder in a theoretical yield of 75.32 g and an actual yield of 92.27% with an HPLC purity of 99.81%. The experiment was repeated four times and the purity was 99.83%, 99.73%, 99.82% and 99.81%, respectively. The moguisteine prepared by this method was of very high purity and did not require further purification.
References
[1] Patent: EP2070915, 2009, A1. Location in patent: Page/Page column 14-15; 20
[2] Patent: EP2070915, 2009, A1. Location in patent: Page/Page column 16-17; 20
Moguisteine Preparation Products And Raw materials
Raw materials
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View Lastest Price from Moguisteine manufacturers
- Product
- Moguisteine 119637-67-1
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2023-10-20
- Product
- Moguisteine 119637-67-1
- Price
- US $200.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg/Month
- Release date
- 2022-11-23
- Product
- Moguisteine 119637-67-1
- Price
- US $100.00/mg
- Min. Order
- 25mg
- Purity
- 99%
- Supply Ability
- 1000g
- Release date
- 2023-03-10