phanquone

Uses

Product Name: phanquone
CAS No.: 84-12-8
Chemical Name: phanquone
Synonyms: C-11925;entobex;enthohex;Entronon;phanquone;Ciba 11925;phanquinone;phanquone USP/EP/BP;4,7-phenanthroline-5,6-dione;4,7-phenanthroline-5,6-quinone
CBNumber: CB7875744
Molecular Formula: C12H6N2O2
Formula Weight: 210.19
MOL File: 84-12-8.mol

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phanquone Property

Melting point:: 295° (dec)
Boiling point:: 349.71°C (rough estimate)
Density: 1.2785 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Storage temp. 2-8°C
pka: -0.30±0.20(Predicted)
form: Solid
color: Crystals from methanol
InChI: InChI=1S/C12H6N2O2/c15-11-9-7(3-1-5-13-9)8-4-2-6-14-10(8)12(11)16/h1-6H
InChIKey: VLPADTBFADIFKG-UHFFFAOYSA-N
SMILES: C1C2=C(C(=O)C(=O)C3=C2C=CC=N3)N=CC=1

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Safety

Toxicity: LD50 orl-rat: 5 mg/kg ANTCAO 8,297,58 orl-mus LD50:4 mg/kg ANTCAO 8,297,58

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0995598
Product name: 4,7-PHENANTHROLINE-5,6-DIONE
Purity: 95.00%
Packaging: 5MG
Price: $502.15
Updated: 2021/12/16

Aronis compounds

Product number: BBC/602
Product name: 4,7-phenanthroline-5,6-dione
Packaging: 1g
Price: $171
Updated: 2021/12/16

Aronis compounds

Product number: BBC/602
Product name: 4,7-phenanthroline-5,6-dione
Packaging: 5g
Price: $355
Updated: 2021/12/16

Crysdot

Product number: CD11048382
Product name: 4,7-Phenanthroline-5,6-dione
Purity: 97%
Packaging: 1g
Price: $416
Updated: 2021/12/16

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phanquone Chemical Properties,Usage,Production

Uses

Phenylamidone drugs are mainly used to treat amoebic dysentery and bacillary dysentery. Most existing synthetic methods involve nitrification, reduction, and hydrolysis of o-acetamipridanisole to produce 2,5-diaminoanisole sulfate, which is then reacted with glycerol and concentrated sulfuric acid in the presence of iodine and potassium iodide under heating to cyclize and obtain 6-methoxy-4,7-diaphenanthrene, which is then further oxidized to obtain the finished product.

Chemical Properties

Orange-red crystalline powder. Melting point 295°C. Slightly soluble in water, insoluble in ethanol and chloroform. Odorless, slightly bitter.

Originator

Phanquinone ,Yick-Vic Chemicals and

Definition

ChEBI: An orthoquinone that is the 5,6-diketo derivative of 4,7-phenanthroline.

Manufacturing Process

2 parts of 6-methoxy-4:7-phenanthroline are mixed with 10 parts by volume of concentrated sulfuric acid and while cooling with a mixture of ice and sodium chloride, with 6 parts by volume of fuming nitric acid (density = 1.51), and the whole is heated for 2 h at 120°C. The reaction solution is poured on to ice, its pH value is adjusted to 7 by means of a 10 N solution of caustic soda, after standing for 2 h the whole is filtered with suction to remove the precipitate which separates, and the latter is washed with hot water. After recrystallising the product from methyl alcohol and drying it at 100°C under 0.1 mm pressure, there are obtained 1.8 parts (i.e. 90 % of the calculated yield) of 4:7-phenanthroline-5:6-quinone in the form of pale yellow crystals melting at 295°C.

Therapeutic Function

Antiamebic

Safety Profile

Poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

The dione crystallises from MeOH. The mono-oxime forms yellow crystals from MeOH with m 250o(dec), the di-oxime forms yellow crystals from MeOH with m 300o(dec) and the mono-semihydrazone forms yellow crystals from MeOH with m 195o(dec). [Druey & Schmidt Helv Chim Acta 33 1080 1950, Beilstein 24 III/IV 1741.]

phanquone Preparation Products And Raw materials

Raw materials

2,5-Diaminoanisole sulfate N-(2-Methoxyphenyl)acetamide Aza Phenanthrene

Preparation Products

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phanquone Suppliers

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View Lastest Price from phanquone manufacturers

Career Henan Chemical Co

Product: phanquone 84-12-8
Price: US $1000.00/KG
Min. Order: 25KG
Purity: 98%
Supply Ability: 10tons
Release date: 2018-07-26

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4,7-phenanthroline-5,6-dione

phanquinone

phanquone

4,7-phenanthrolene-5,6-quinone

enthohex

entobex

C-11925

Ciba 11925

Entronon

4,7-phenanthroline-5,6-quinone

phanquone USP/EP/BP

84-12-8