9-Oxo-10(9H)-acridineacetic acid

Product Name: 9-Oxo-10(9H)-acridineacetic acid
CAS No.: 38609-97-1
Chemical Name: 9-Oxo-10(9H)-acridineacetic acid
Synonyms: ACRIDONE ACETIC ACID;Cridanimod;10-carboxymethyl-9-acridanone;10-Cma;XBIO-101;AI3-05733;HSDB 2647;Aids000901;Aids-000901;Brn 0227508
CBNumber: CB0502504
Molecular Formula: C15H11NO3
Formula Weight: 253.25
MOL File: 38609-97-1.mol

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9-Oxo-10(9H)-acridineacetic acid Property

Melting point:: ~289 °C (dec.)
Boiling point:: 486.6±34.0 °C(Predicted)
Density: 1.362
storage temp.: Sealed in dry,Room Temperature
solubility: Aqueous Base (Slightly), DMSO (Slightly)
form: Solid
pka: 3.69±0.10(Predicted)
color: Pale Yellow to Light Yellow
λmax: 410nm(H2O)(lit.)
BRN: 227508
InChI: InChI=1S/C15H11NO3/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16/h1-8H,9H2,(H,17,18)
InChIKey: UOMKBIIXHQIERR-UHFFFAOYSA-N
SMILES: C1=C2C(N(CC(O)=O)C3=C(C2=O)C=CC=C3)=CC=C1
CAS DataBase Reference: 38609-97-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
RTECS: AR7190000
HS Code: 2933.99.8290

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 17927
Product name: 9-Oxo-10(9H)-acridineacetic acid
Purity: for HPLC derivatization, ≥99.0% (T)
Packaging: 250mg
Price: $317
Updated: 2024/03/01

TCI Chemical

Product number: O0432
Product name: 9-Oxoacridine-10-acetic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $78
Updated: 2024/03/01

TCI Chemical

Product number: O0432
Product name: 9-Oxoacridine-10-acetic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $234
Updated: 2024/03/01

TRC

Product number: O870098
Product name: 9-Oxo-10(9H)-acridineacetic acid
Packaging: 250mg
Price: $140
Updated: 2021/12/16

TRC

Product number: O870098
Product name: 9-Oxo-10(9H)-acridineacetic acid
Packaging: 100mg
Price: $90
Updated: 2021/12/16

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9-Oxo-10(9H)-acridineacetic acid Chemical Properties,Usage,Production

Definition

Acriridone derivatives have become a research hotspot in the field of medicine in recent years due to their good antibacterial, anti-inflammatory, anti-malarial, and anti-cancer activities. This type of compound has a rigid planar structure of a macrocyclic conjugated system and can be embedded or Electrostatic attraction binds to DNA. Among them, 9-aminoacridine derivatives have good pharmacological and biological activities, and some of them have been used clinically as DNA embedding reagents. As an important pharmaceutical intermediate, 9-Oxo-10(9H)-acridineacetic acid has also received increasing attention. Cridanimod (9-Oxo-10(9H)-acridineacetic acid) is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer.

Description

9-Oxo-10(9H)-acridineacetic acid , also known as Cridanimod or XBIO-101, is a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells.

Uses

9-Oxo-10(9H)-acridineacetic acid is a reagent for pre-column derivatization of amino acids for fluorescent determination in HPLC and it is also a building block in pharmaceutics.

Definition

ChEBI: Cridanimod is a member of acridines. It is functionally related to an acridone.

storage

Store at +4°C

9-Oxo-10(9H)-acridineacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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9-Oxo-10(9H)-acridineacetic acid Suppliers

Americas 1 China 156 Europe 3 Germany 4 India 3 Japan 2 South Korea 1 Switzerland 1 Ukraine 1 United Kingdom 5 United States 14 USA 1 Global 192

Zhengzhou Yuanli Biological Technology Co., Ltd.

Tel: 0371-67897870 18339906974
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Chongqing Xingcan Pharmaceutical Technology Co., Ltd.

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INTATRADE GmbH

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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JinYan Chemicals(ShangHai) Co.,Ltd.

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Adamas Reagent, Ltd.

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Tianjin heowns Biochemical Technology Co., Ltd.

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Wuhan Kemi-Works Chemical Co., Ltd

Tel: 027-85736489
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Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
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View Lastest Price from 9-Oxo-10(9H)-acridineacetic acid manufacturers

Hebei Mojin Biotechnology Co., Ltd

Product: 9-Oxo-10(9H)-acridineacetic acid 38609-97-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.6%
Supply Ability: 50000KG/month
Release date: 2024-10-22

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: 9-Oxo-10(9H)-acridineacetic acid 38609-97-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-04-08

Henan Fengda Chemical Co., Ltd

Product: 9-Oxo-10(9H)-acridineacetic acid 38609-97-1
Price: US $50.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-22

38609-97-1, 9-Oxo-10(9H)-acridineacetic acidRelated Search:

Glycine Citric acid 2-ETHOXY-6,9-DIAMINOACRIDINE Amsacrine hydrochloride 6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE 9(10H)-ACRIDONE Basic Orange 14 Ethyl 2-(Chlorosulfonyl)acetate Ethyl acetate Quinacridone Folic acid Ascoric Acid Chloroacetic acid Acetic anhydride CARBAZINE 10-METHYL-9(10H)-ACRIDONE (DIPHENYLAMINO)ACETIC ACID Camedon

N-(Carboxymethyl)-9-acridone

10-CARBOXYMETHYL-9-ACRIDANONE;10-CMA;XBIO-101

XBIO-101

10-carboxymethyl-9-acridanone

Cridanimod

Aridone acetic acid

Cridanimod sodium

9-Oxo-9,10-dihydro-10-acridineacetic acid

9-oxo-10(9h)-acridineaceticaci

9-oxo-10(9h)-acridineaceticacid

(9 10-DIHYDRO-9-OXO-10-ACRIDINYL)ACETIC

acridin-9(10H)-one-n-acetic acid

ACRIDONE ACETIC ACID

(9-Oxo-10(9H)-acridinyl)acetic acid

10-Carboxymethylacridin-9(10H)-one

(9,10-Dihydro-9-oxo-10-acridinyl)acetic acid, 10-(Carboxymethyl)-9(10H)acridone

10(9H)-Acridineacetic acid, 9-oxo-

10-Cma

Aids000901

Aids-000901

Brn 0227508

N-(Carboxymethyl)acridone

Acridone acetic acid SynonyMs (9-Oxo-10(9H)-acridinyl)acetic acid

10-(Carboxymethyl)-9(10H)acridone

9-Oxoacridine-10-acetic Acid

2-(9-Oxoacridin-10(9H)-yl)acetic acid

10-Carboxymeth-9-acridanone

2-(9-ketoacridin-10-yl)acetic acid

2-(9-oxo-10-acridinyl)acetic acid

2-(9-oxoacridin-10-yl)ethanoic acid

9-Oxoacridine-10-aceticAcid&gt

9-Oxo-1(9H)-acridineacetic acid

TIANFU-CHEM 38609-97-1 9-Oxo-10(9H)-acridineacetic acid

AI3-05733

BRN 1786567

EINECS 205-571-1

HSDB 2647

CMA|||XBIO-101|||10-carboxymethyl-9-acridanone

Acridinone acetate

38609-97-1