ChemicalBook > CAS DataBase List > 9-Oxo-10(9H)-acridineacetic acid

9-Oxo-10(9H)-acridineacetic acid

Product Name
9-Oxo-10(9H)-acridineacetic acid
CAS No.
38609-97-1
Chemical Name
9-Oxo-10(9H)-acridineacetic acid
Synonyms
ACRIDONE ACETIC ACID;Cridanimod;10-carboxymethyl-9-acridanone;10-Cma;XBIO-101;AI3-05733;HSDB 2647;Aids000901;Aids-000901;Brn 0227508
CBNumber
CB0502504
Molecular Formula
C15H11NO3
Formula Weight
253.25
MOL File
38609-97-1.mol
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9-Oxo-10(9H)-acridineacetic acid Property

Melting point:
~289 °C (dec.)
Boiling point:
486.6±34.0 °C(Predicted)
Density 
1.362
storage temp. 
Sealed in dry,Room Temperature
solubility 
Aqueous Base (Slightly), DMSO (Slightly)
form 
Solid
pka
3.69±0.10(Predicted)
color 
Pale Yellow to Light Yellow
λmax
410nm(H2O)(lit.)
BRN 
227508
InChI
InChI=1S/C15H11NO3/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16/h1-8H,9H2,(H,17,18)
InChIKey
UOMKBIIXHQIERR-UHFFFAOYSA-N
SMILES
C1=C2C(N(CC(O)=O)C3=C(C2=O)C=CC=C3)=CC=C1
CAS DataBase Reference
38609-97-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
RTECS 
AR7190000
HS Code 
2933.99.8290
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
17927
Product name
9-Oxo-10(9H)-acridineacetic acid
Purity
for HPLC derivatization, ≥99.0% (T)
Packaging
250mg
Price
$317
Updated
2024/03/01
TCI Chemical
Product number
O0432
Product name
9-Oxoacridine-10-acetic Acid
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$78
Updated
2024/03/01
TCI Chemical
Product number
O0432
Product name
9-Oxoacridine-10-acetic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$234
Updated
2024/03/01
TRC
Product number
O870098
Product name
9-Oxo-10(9H)-acridineacetic acid
Packaging
250mg
Price
$140
Updated
2021/12/16
TRC
Product number
O870098
Product name
9-Oxo-10(9H)-acridineacetic acid
Packaging
100mg
Price
$90
Updated
2021/12/16
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9-Oxo-10(9H)-acridineacetic acid Chemical Properties,Usage,Production

Definition

Acriridone derivatives have become a research hotspot in the field of medicine in recent years due to their good antibacterial, anti-inflammatory, anti-malarial, and anti-cancer activities. This type of compound has a rigid planar structure of a macrocyclic conjugated system and can be embedded or Electrostatic attraction binds to DNA. Among them, 9-aminoacridine derivatives have good pharmacological and biological activities, and some of them have been used clinically as DNA embedding reagents. As an important pharmaceutical intermediate, 9-Oxo-10(9H)-acridineacetic acid has also received increasing attention. Cridanimod (9-Oxo-10(9H)-acridineacetic acid) is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer.

Description

9-Oxo-10(9H)-acridineacetic acid , also known as Cridanimod or XBIO-101, is a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells.

Uses

9-Oxo-10(9H)-acridineacetic acid is a reagent for pre-column derivatization of amino acids for fluorescent determination in HPLC and it is also a building block in pharmaceutics.

Definition

ChEBI: Cridanimod is a member of acridines. It is functionally related to an acridone.

storage

Store at +4°C

9-Oxo-10(9H)-acridineacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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9-Oxo-10(9H)-acridineacetic acid Suppliers

Zhengzhou Yuanli Biological Technology Co., Ltd.
Tel
0371-67897870 18339906974
Fax
0371-63507390
Email
2130541246@qq.com
Country
China
ProdList
109
Advantage
58
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Tel
15523000485
Email
xingcanyaoye@sina.com
Country
China
ProdList
1686
Advantage
58
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
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66
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
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61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
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60
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
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59
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
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57
Wuhan Kemi-Works Chemical Co., Ltd
Tel
027-85736489
Fax
86-27-85736485
Email
info@kemiworks.net
Country
China
ProdList
540
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
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62
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View Lastest Price from 9-Oxo-10(9H)-acridineacetic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
9-Oxo-10 (9H) -Acridineacetic Acid 38609-97-1
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-19
Hebei Mojin Biotechnology Co., Ltd
Product
9-Oxo-10(9H)-acridineacetic acid 38609-97-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99.6%
Supply Ability
50000KG/month
Release date
2024-10-22
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
9-Oxo-10(9H)-acridineacetic acid 38609-97-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-08

38609-97-1, 9-Oxo-10(9H)-acridineacetic acidRelated Search:


  • N-(Carboxymethyl)-9-acridone
  • 10-CARBOXYMETHYL-9-ACRIDANONE;10-CMA;XBIO-101
  • XBIO-101
  • 10-carboxymethyl-9-acridanone
  • Cridanimod
  • Aridone acetic acid
  • Cridanimod sodium
  • 9-Oxo-9,10-dihydro-10-acridineacetic acid
  • 9-oxo-10(9h)-acridineaceticaci
  • 9-oxo-10(9h)-acridineaceticacid
  • (9 10-DIHYDRO-9-OXO-10-ACRIDINYL)ACETIC
  • acridin-9(10H)-one-n-acetic acid
  • ACRIDONE ACETIC ACID
  • (9-Oxo-10(9H)-acridinyl)acetic acid
  • 10-Carboxymethylacridin-9(10H)-one
  • (9,10-Dihydro-9-oxo-10-acridinyl)acetic acid, 10-(Carboxymethyl)-9(10H)acridone
  • 10(9H)-Acridineacetic acid, 9-oxo-
  • 10-Cma
  • Aids000901
  • Aids-000901
  • Brn 0227508
  • N-(Carboxymethyl)acridone
  • Acridone acetic acid SynonyMs (9-Oxo-10(9H)-acridinyl)acetic acid
  • 10-(Carboxymethyl)-9(10H)acridone
  • 9-Oxoacridine-10-acetic Acid
  • 2-(9-Oxoacridin-10(9H)-yl)acetic acid
  • 10-Carboxymeth-9-acridanone
  • 2-(9-ketoacridin-10-yl)acetic acid
  • 2-(9-oxo-10-acridinyl)acetic acid
  • 2-(9-oxoacridin-10-yl)ethanoic acid
  • 9-Oxoacridine-10-aceticAcid&gt
  • 9-Oxo-1(9H)-acridineacetic acid
  • TIANFU-CHEM 38609-97-1 9-Oxo-10(9H)-acridineacetic acid
  • AI3-05733
  • BRN 1786567
  • EINECS 205-571-1
  • HSDB 2647
  • CMA|||XBIO-101|||10-carboxymethyl-9-acridanone
  • Acridinone acetate
  • 38609-97-1
  • 38609-97-1