(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile

Product Name: (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
CAS No.: 38321-02-7
Chemical Name: (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
Synonyms: d-Verapamil;Dexverapami;Dexverapamil;Dexverapamil Hydrochloride;[R,(+)]-2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(N-methyl-3,4-dimethoxyphenethylamino)valeronitrile;(R)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile;(aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile;(αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile;Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (R)-;Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, (αR)-
CBNumber: CB7941337
Molecular Formula: C27H38N2O4
Formula Weight: 454.61
MOL File: 38321-02-7.mol

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(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Property

Melting point:: 129-131°C
Boiling point:: 586.1±50.0 °C(Predicted)
Density: 1.058±0.06 g/cm3(Predicted)
pka: 8.97±0.50(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0000091
Product name: R(+)-VERAPAMIL
Purity: 95.00%
Packaging: 1MG
Price: $757.97
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000091
Product name: R(+)-VERAPAMIL
Purity: 95.00%
Packaging: 10MG
Price: $2243.59
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 14156
Product name: (R)-(+)-VerapamilHCl
Packaging: 5mg
Price: $2400
Updated: 2021/12/16

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(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells

Definition

ChEBI: A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby p tentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil.

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Suppliers

Canada 1 China 5 India 2 United Kingdom 1 United States 4 Global 13

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38321-02-7, (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrileRelated Search:

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile 2-(4-Methoxyphenyl)-2-methylpropanenitrile Devapamil (+/-)-Verapamil hydrochloride METHOXY-(-)-VERAPAMIL HYDROCHLORIDE R(+)-VERAPAMIL HYDROCHLORIDE 3-Methyl-2-(3,4-dimethoxyphenyl)butyronitrile 4-HYDROXY-3-METHOXYPHENYLACETONITRILE Verapamil (3,4-Dimethoxyphenyl)acetonitrile Benzeneacetonitrile Valeronitrile P-O-DESMETHYL VERAPAMIL 1-(3,4-DIMETHOXYPHENYL)-VALERONITRILE NORVERAPAMIL Emopamil 2-(3-METHOXYPHENYL)-2-METHYLPROPANENITRILE 2-(4-HYDROXYPHENYL)-2-METHYLPROPANENITRILE

Dexverapamil

(aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile

Dexverapami

Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (aR)- (9CI)

Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (R)-

d-Verapamil

(aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile Hydrochloride

Dexverapamil Hydrochloride

(R)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile

(αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile

[R,(+)]-2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(N-methyl-3,4-dimethoxyphenethylamino)valeronitrile

Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, (αR)-

38321-02-7

C27H39ClN2O4

Intermediates & Fine Chemicals

Pharmaceuticals