ChemicalBook > CAS DataBase List > 3-Methyl-4-nitropyrazole

3-Methyl-4-nitropyrazole

Uses

Product Name: 3-Methyl-4-nitropyrazole
CAS No.: 5334-39-4
Chemical Name: 3-Methyl-4-nitropyrazole
Synonyms: 3-Methyl-4-nitropyra;at-7519-lua2-3-261-156g;3-Methyl-4-nitropyrazole;3-Methyl-4-nitropyrazole>1H-Pyrazole, 3-methyl-4-nitro-;3-Methyl-4-nitro-1H-pyrazole,97%;1H-Pyrazole,3-methyl-4-nitro-(9CI);3-Methyl-4-Nitro-1H-Pyrazole;3-Methyl-4-Nitro-1H-Pyrazole
CBNumber: CB7947506
Molecular Formula: C4H5N3O2
Formula Weight: 127.1
MOL File: 5334-39-4.mol

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3-Methyl-4-nitropyrazole Property

Melting point:: 131-134℃
Boiling point:: 325℃
Density: 1.426±0.06 g/cm3(Predicted)
RTECS: UQ7435000
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 10.19±0.50(Predicted)
color: White to Light yellow
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C4H5N3O2/c1-3-4(7(8)9)2-5-6-3/h2H,1H3,(H,5,6)
InChIKey: WTZYTQJELOHMMJ-UHFFFAOYSA-N
SMILES: N1C=C([N+]([O-])=O)C(C)=N1

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-37
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2469
Product name: 3-Methyl-4-nitropyrazole
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $54
Updated: 2025/07/31

TCI Chemical

Product number: M2469
Product name: 3-Methyl-4-nitropyrazole
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $249
Updated: 2021/12/16

TRC

Product number: M320110
Product name: 3-Methyl-4-nitropyrazole
Packaging: 1g
Price: $55
Updated: 2021/12/16

TRC

Product number: M320110
Product name: 3-Methyl-4-nitropyrazole
Packaging: 10g
Price: $145
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0010717
Product name: 3-METHYL-4-NITRO PYRAZOLE
Purity: 95.00%
Packaging: 5G
Price: $845.34
Updated: 2021/12/16

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3-Methyl-4-nitropyrazole Chemical Properties,Usage,Production

Uses

3-Methyl-4-nitropyrazole is a reactant used in the preparation of aminopyrazole derivatives as potent, selective and brain penetrant Leucine-rich repeat kinase 2(LRRK2) small molecule inhibitors.

Uses

3-Methyl-4-nitropyrazole is a reactant used in the preparation of aminopyrazole derivatives as potent, selective and brain penetrant Leucine-rich repeat kinase 2(LRRK2) small molecule inhibitors.

Synthesis

15802-75-2

5334-39-4

General method: 3-methyl-4-iodopyrazole (1 mmol) was dissolved in tetrahydrofuran (THF, 10 mL) and Fuajasite catalyst (250 mg) was added. Concentrated nitric acid (density 1.52 g/cm3, 10 mL) was added slowly and the reaction was stirred at room temperature until completion. At the end of the reaction, the catalyst was removed by filtration and the filtrate was extracted with dichloromethane several times. The organic phases were combined and concentrated under reduced pressure to remove the solvent to obtain 3-methyl-4-nitropyrazole.

References

[1] Synthetic Communications, 2012, vol. 42, # 23, p. 3463 - 3471
[2] Catalysis Communications, 2013, vol. 42, p. 35 - 39

3-Methyl-4-nitropyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Methyl-4-nitropyrazole manufacturers

Career Henan Chemical Co

Product: 3-Methyl-4-nitropyrazole 5334-39-4
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-08-05

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