3-Methyl-4-nitropyrazole
Uses- Product Name
- 3-Methyl-4-nitropyrazole
- CAS No.
- 5334-39-4
- Chemical Name
- 3-Methyl-4-nitropyrazole
- Synonyms
- 3-Methyl-4-nitropyra;at-7519-lua2-3-261-156g;3-Methyl-4-nitropyrazole;3-Methyl-4-nitropyrazole>1H-Pyrazole, 3-methyl-4-nitro-;3-Methyl-4-nitro-1H-pyrazole,97%;1H-Pyrazole,3-methyl-4-nitro-(9CI);3-Methyl-4-Nitro-1H-Pyrazole;3-Methyl-4-Nitro-1H-Pyrazole
- CBNumber
- CB7947506
- Molecular Formula
- C4H5N3O2
- Formula Weight
- 127.1
- MOL File
- 5334-39-4.mol
3-Methyl-4-nitropyrazole Property
- Melting point:
- 131-134℃
- Boiling point:
- 325℃
- Density
- 1.426±0.06 g/cm3(Predicted)
- RTECS
- UQ7435000
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 10.19±0.50(Predicted)
- color
- White to Light yellow
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C4H5N3O2/c1-3-4(7(8)9)2-5-6-3/h2H,1H3,(H,5,6)
- InChIKey
- WTZYTQJELOHMMJ-UHFFFAOYSA-N
- SMILES
- N1C=C([N+]([O-])=O)C(C)=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M2469
- Product name
- 3-Methyl-4-nitropyrazole
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $54
- Updated
- 2025/07/31
- Product number
- M2469
- Product name
- 3-Methyl-4-nitropyrazole
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $249
- Updated
- 2021/12/16
- Product number
- M320110
- Product name
- 3-Methyl-4-nitropyrazole
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- M320110
- Product name
- 3-Methyl-4-nitropyrazole
- Packaging
- 10g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- CHM0010717
- Product name
- 3-METHYL-4-NITRO PYRAZOLE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $845.34
- Updated
- 2021/12/16
3-Methyl-4-nitropyrazole Chemical Properties,Usage,Production
Uses
3-Methyl-4-nitropyrazole is a reactant used in the preparation of aminopyrazole derivatives as potent, selective and brain penetrant Leucine-rich repeat kinase 2(LRRK2) small molecule inhibitors.
Uses
3-Methyl-4-nitropyrazole is a reactant used in the preparation of aminopyrazole derivatives as potent, selective and brain penetrant Leucine-rich repeat kinase 2(LRRK2) small molecule inhibitors.
Synthesis
15802-75-2
5334-39-4
General method: 3-methyl-4-iodopyrazole (1 mmol) was dissolved in tetrahydrofuran (THF, 10 mL) and Fuajasite catalyst (250 mg) was added. Concentrated nitric acid (density 1.52 g/cm3, 10 mL) was added slowly and the reaction was stirred at room temperature until completion. At the end of the reaction, the catalyst was removed by filtration and the filtrate was extracted with dichloromethane several times. The organic phases were combined and concentrated under reduced pressure to remove the solvent to obtain 3-methyl-4-nitropyrazole.
References
[1] Synthetic Communications, 2012, vol. 42, # 23, p. 3463 - 3471
[2] Catalysis Communications, 2013, vol. 42, p. 35 - 39
3-Methyl-4-nitropyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
3-Methyl-4-nitropyrazole Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from 3-Methyl-4-nitropyrazole manufacturers
- Product
- 3-Methyl-4-nitropyrazole 5334-39-4
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-05