N-phenyl isonicotinamide
- Product Name
- N-phenyl isonicotinamide
- CAS No.
- 3034-31-9
- Chemical Name
- N-phenyl isonicotinamide
- Synonyms
- SKL864;NSC 4266;Isonicotinanilide;N-Phenyl isonicotinicamide;1,2-Ethanediamine,4-phenyl-;N-Phenyl isonicotinamide ,97%;4-(N-Phenylcarbamoyl)pyridine;N-Phenyl-4-pyridinecarboxamide;N-phenylpyridine-4-carboxamide;4-Pyridinecarboxamide,N-phenyl-
- CBNumber
- CB7950393
- Molecular Formula
- C12H10N2O
- Formula Weight
- 198.22
- MOL File
- 3034-31-9.mol
N-phenyl isonicotinamide Property
- Melting point:
- 170-172℃
- Boiling point:
- 266℃
- Density
- 1.227
- Flash point:
- 115℃
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 11.85±0.70(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P335483
- Product name
- N-PhenylIsonicotinicamide
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- JK163308
- Product name
- N-Phenylisonicotinamide
- Purity
- 97%
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
- Product number
- JK163308
- Product name
- N-Phenylisonicotinamide
- Purity
- 97%
- Packaging
- 5g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- W5276
- Product name
- N-Phenylisonicotinicamide
- Packaging
- 5g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- JK163308
- Product name
- N-Phenylisonicotinamide
- Purity
- 97%
- Packaging
- 10g
- Price
- $151
- Updated
- 2021/12/16
N-phenyl isonicotinamide Chemical Properties,Usage,Production
Chemical Properties
White to light yellow or grey solid
Synthesis
55-22-1
62-53-3
3034-31-9
General procedure for the synthesis of N-phenylisonicotinamide from isonicotinic acid and aniline: isonicotinic acid (14.5 g, 40.6 mmol) was dissolved in thionyl chloride (40 mL) and heated to reflux for 2 hours. After completion of the reaction, thionyl chloride was removed by distillation under reduced pressure. To the residue was added THF (50 mL), K2CO3 (16.8 g, 121.9 mmol) and aniline (3.78 g, 40.6 mmol), and the reaction mixture was stirred at room temperature for 24 hours. After completion of the reaction, the reaction mixture was diluted with water (100 mL) and extracted with EtOAc (2 x 100 mL). The organic layers were combined, concentrated, and the residue was recrystallized with EtOAc-hexane (60:40) to afford the light yellow solid product N-phenylisonicotinamide (8.0 g, 99% yield) with melting point 166-168 °C. IR (KBr) νmax 1344, 1653, 1465, 665 cm-1 ; 1H NMR (DMSO-d6, 300 MHz) δ 10.49 (s, 1H), 8.78 (m, 2H), 7.86 (m, 2H), 7.78 (m, 2H), 7.39 (t, J = 8.0 Hz, 2H), 7.15 (t, J = 6.5 Hz, 1H).
References
[1] Patent: WO2017/160898, 2017, A1. Location in patent: Paragraph 00105; 00125
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 4, p. 1370 - 1387
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 11, p. 6027 - 6033
[4] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981, vol. 20, # 11, p. 1007 - 1008
N-phenyl isonicotinamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-phenyl isonicotinamide manufacturers
- Product
- N-phenylpyridine-4-carboxamide 3034-31-9
- Price
- US $4.60/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2021-09-24
- Product
- N-Phenylisonicotinamide 3034-31-9
- Price
- US $4.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-09-24
- Product
- Isonicotinanilide 3034-31-9
- Price
- US $4.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2021-11-26