5-Fluoro-3-iodo-1H-indazole
- Product Name
- 5-Fluoro-3-iodo-1H-indazole
- CAS No.
- 858629-06-8
- Chemical Name
- 5-Fluoro-3-iodo-1H-indazole
- Synonyms
- 5-Fluoro-3-iodo-1H-indazole;5-fluoro-3-iodo-2H-indazole;1H-INDAZOLE,5-FLUORO-3-IODO-;5-FLUORO-3-IODO-1H-INDAZOLE 98%;5-fluoro-3-iodo-1H-indazole(SALTDATA: FREE)
- CBNumber
- CB7970672
- Molecular Formula
- C7H4FIN2
- Formula Weight
- 262.02
- MOL File
- 858629-06-8.mol
5-Fluoro-3-iodo-1H-indazole Property
- Boiling point:
- 361.4±22.0 °C(Predicted)
- Density
- 2.158±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 10.94±0.40(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C7H4FIN2/c8-4-1-2-6-5(3-4)7(9)11-10-6/h1-3H,(H,10,11)
- InChIKey
- CZUPBTJBMHZBTJ-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(F)C=C2)C(I)=N1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B435018
- Product name
- 5-Fluoro-3-iodo-1H-indazole
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- L822
- Product name
- 5-Fluoro-3-iodo-1H-indazole
- Packaging
- 1g
- Price
- $96
- Updated
- 2021/12/16
- Product number
- HCH0013607
- Product name
- 5-FLUORO-3-IODO-1H-INDAZOLE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1672.44
- Updated
- 2021/12/16
- Product number
- PC8399
- Product name
- 5-Fluoro-3-iodo-1H-indazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
- Product number
- 3H32-K-X6
- Product name
- 5-Fluoro-3-iodo-1H-indazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
5-Fluoro-3-iodo-1H-indazole Chemical Properties,Usage,Production
Synthesis
348-26-5
858629-06-8
5-Fluoro-1H-indazole (2.0 g, 14.0 mmol) was used as raw material and dissolved in DIVIF (50 mL). To this solution, iodine (7.46 g, 28.0 mmol) and potassium hydroxide (2.4 g, 42 mmol) were added sequentially at 0 °C. The reaction mixture was stirred at 0 °C for 0.5 h and then gradually warmed up to room temperature. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was filtered and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=3/1) to afford 5-fluoro-3-iodo-1H-indazole (3.7 g, yield: 96.1%) as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ=13.64 (s, 1H), 7.63 (dd, J=4.8,4.4 Hz, 1H), 7.38-7.30 (m, 1H), 7.20 (dd, J=6.4,2.4 Hz, 1H).
References
[1] Patent: WO2018/132372, 2018, A1. Location in patent: Paragraph 01229
[2] Patent: WO2018/188590, 2018, A1. Location in patent: Paragraph 00437
[3] Synthesis, 2011, # 19, p. 3089 - 3098
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5419 - 5434
[5] Molecules, 2018, vol. 23, # 8,
5-Fluoro-3-iodo-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
5-Fluoro-3-iodo-1H-indazole Suppliers
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View Lastest Price from 5-Fluoro-3-iodo-1H-indazole manufacturers
- Product
- 5-Fluoro-3-iodo-1H-indazole 858629-06-8
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-13