ChemicalBook > CAS DataBase List > Alvespimycin

Alvespimycin

Product Name
Alvespimycin
CAS No.
467214-20-6
Chemical Name
Alvespimycin
Synonyms
17-DMAG;17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin;17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin;CS-2382;DMAG-d6;17-DMAG-d6;spiromycin;17-DMAG HCI;Alvespimycin;NSC 707545-d6
CBNumber
CB7972636
Molecular Formula
C32H48N4O8
Formula Weight
616.75
MOL File
467214-20-6.mol
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Alvespimycin Property

Melting point:
>270°C (dec.)
Boiling point:
810.5±65.0 °C(Predicted)
Density 
1.20
storage temp. 
Desiccate at -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
8.48±0.70(Predicted)
color 
Very Dark Purple
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Safety

HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11036
Product name
17-DMAG
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
11036
Product name
17-DMAG
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
11036
Product name
17-DMAG
Purity
≥98%
Packaging
10mg
Price
$195
Updated
2024/03/01
Tocris
Product number
2610
Product name
17-DMAGhydrochloride
Purity
≥99%(HPLC)
Packaging
1
Price
$255
Updated
2021/12/16
Usbiological
Product number
207011
Product name
17-DMAG
Packaging
100ug
Price
$273
Updated
2021/12/16
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Alvespimycin Chemical Properties,Usage,Production

Description

Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals. Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer. This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway. 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes.

Chemical Properties

Solid

Uses

17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.

Uses

The labelled derivative of the analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). It acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.

Uses

17-DMAG is a synthetic Geldanamycin derivative and inhibitor of Hsp90.

Definition

ChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group.

Biological Activity

Water-soluble analog of 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI 50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

Alvespimycin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Alvespimycin manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
Alvespimycin 467214-20-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-29
Hebei Duling International Trade Co. LTD
Product
Alvespimycin 467214-20-6
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50 tons
Release date
2023-04-19
Zhuozhou Wenxi import and Export Co., Ltd
Product
Alvespimycin 467214-20-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

467214-20-6, AlvespimycinRelated Search:

N,N-Dimethylformamide 3-Dimethylaminopropylamine Spiramycin N,N-Dimethylacetamide N,N-Dimethyl-1,4-phenylenediamine Dimethyl sulfone Ethyl propiolate Ethyl acrylate Acetylspiramycin Dimethyl sulfoxide Poly(dimethylsiloxane) ISOXADIFEN-ETHYL Trinexapac-ethyl Ethylparaben Ethyl cyanoacetate Ethyl acetate Ethanol 17-DMAG

  • 17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXYG
  • 17-DMAGhydrochloride
  • 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin
  • 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin
  • Alvespimycin
  • 17-DMAG (Alvespimycin)
  • 17-DMAG
  • Unii-001L2fe0m3
  • 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycinhydrochloride
  • 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin
  • 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin-d6
  • 17-[2-(DiMethylaMino)ethylaMino]-17-desMethylgeldanaMycin Hydrochloride
  • (150270-08-9) alvespimycin
  • CS-2382
  • 17-DMAG;KOS-1022;NSC-707545
  • 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin Hydrochloride
  • 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxygeldanaMycin Hydrochloride
  • DMAG Hydrochloride
  • NSC 707545 Hydrochloride
  • 17-[2-[(DiMethyl-d6)aMino]ethylaMino]-17-desMethylgeldanaMycin
  • 17-DeMethoxy-17-[[2-[(diMethyl-d6)aMino]ethyl]aMino]geldanaMycin
  • 17-DMAG-d6
  • 17-N-[(diMethyl-d6)aMinoethylaMino]-17-deMethoxygeldanaMycin
  • AlvespiMycin-d6
  • DMAG-d6
  • NSC 707545-d6
  • AlvespiMycin freebase
  • In-house Standard
  • 17DMAG (17-diMethylaMinoethylaMino-17-deMethoxy-geldanaMycin)
  • AlvespiMycin(17-DMAG)
  • 17-DMAG/ Alvespimycin/ 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin
  • Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-
  • 17-DMAG HCI
  • spiromycin
  • 467214-20-6
  • C32H48N4O8HCl
  • Isotope Labelled Compounds
  • Amines
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals