Alvespimycin

ChemicalBook > CAS DataBase List > Alvespimycin

Product Name: Alvespimycin
CAS No.: 467214-20-6
Chemical Name: Alvespimycin
Synonyms: 17-DMAG;17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin;17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin;CS-2382;DMAG-d6;17-DMAG-d6;spiromycin;17-DMAG HCI;Alvespimycin;NSC 707545-d6
CBNumber: CB7972636
Molecular Formula: C32H48N4O8
Formula Weight: 616.75
MOL File: 467214-20-6.mol

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Alvespimycin Property

Melting point:: >270°C (dec.)
Boiling point:: 810.5±65.0 °C(Predicted)
Density: 1.20
storage temp.: Desiccate at -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 8.48±0.70(Predicted)
color: Very Dark Purple

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Safety

HS Code: 29419090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11036
Product name: 17-DMAG
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 11036
Product name: 17-DMAG
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 11036
Product name: 17-DMAG
Purity: ≥98%
Packaging: 10mg
Price: $195
Updated: 2024/03/01

Tocris

Product number: 2610
Product name: 17-DMAGhydrochloride
Purity: ≥99%(HPLC)
Packaging: 1
Price: $255
Updated: 2021/12/16

Usbiological

Product number: 207011
Product name: 17-DMAG
Packaging: 100ug
Price: $273
Updated: 2021/12/16

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Alvespimycin Chemical Properties,Usage,Production

Description

Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC₅₀ = 24 nM) and has excellent bioavailability and tissue distribution in animals. Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer. This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway. 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes.

Chemical Properties

Solid

Uses

17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.

Uses

The labelled derivative of the analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). It acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.

Uses

17-DMAG is a synthetic Geldanamycin derivative and inhibitor of Hsp90.

Definition

ChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group.

Biological Activity

Water-soluble analog of 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI 50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

Alvespimycin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Alvespimycin manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Alvespimycin 467214-20-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-29

Zhuozhou Wenxi import and Export Co., Ltd

Product: Alvespimycin 467214-20-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Alvespimycin 467214-20-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

467214-20-6, AlvespimycinRelated Search:

N,N-Dimethylformamide 3-Dimethylaminopropylamine Spiramycin N,N-Dimethylacetamide N,N-Dimethyl-1,4-phenylenediamine Dimethyl sulfone Ethyl propiolate Ethyl acrylate Acetylspiramycin Dimethyl sulfoxide Poly(dimethylsiloxane) ISOXADIFEN-ETHYL Trinexapac-ethyl Ethylparaben Ethyl cyanoacetate Ethyl acetate Ethanol 17-DMAG

17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXYG

17-DMAGhydrochloride

17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin

17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin

Alvespimycin

17-DMAG (Alvespimycin)

17-DMAG

Unii-001L2fe0m3

17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycinhydrochloride

17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin

17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin-d6

17-[2-(DiMethylaMino)ethylaMino]-17-desMethylgeldanaMycin Hydrochloride

(150270-08-9) alvespimycin

CS-2382

17-DMAG;KOS-1022;NSC-707545

17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin Hydrochloride

17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxygeldanaMycin Hydrochloride

DMAG Hydrochloride

NSC 707545 Hydrochloride

17-[2-[(DiMethyl-d6)aMino]ethylaMino]-17-desMethylgeldanaMycin

17-DeMethoxy-17-[[2-[(diMethyl-d6)aMino]ethyl]aMino]geldanaMycin

17-DMAG-d6

17-N-[(diMethyl-d6)aMinoethylaMino]-17-deMethoxygeldanaMycin

AlvespiMycin-d6

DMAG-d6

NSC 707545-d6

AlvespiMycin freebase

In-house Standard

17DMAG (17-diMethylaMinoethylaMino-17-deMethoxy-geldanaMycin)

AlvespiMycin(17-DMAG)

17-DMAG/ Alvespimycin/ 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin

Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-

17-DMAG HCI

spiromycin

Dimethylaminoethylamino-17-demethoxygeldanamycin, 17-

467214-20-6

C32H48N4O8HCl

Isotope Labelled Compounds

Amines

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals