ChemicalBook > CAS DataBase List > magnessium lithospermate B

magnessium lithospermate B

Product Name: magnessium lithospermate B
CAS No.: 122021-74-3
Chemical Name: magnessium lithospermate B
Synonyms: Magnesium Salvianolate B;Magnesium Lithospermate B;magnessium lithospermate B;Monomethyl lithospermate B;MAGNESIUM LITHOSPERMATE B 98%;Magnesium Lithospermate B, 10 mM in DMSO;magnesium,2-[(E)-3-[3-[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoate;Magnesium 4-((R)-2-carboxy-2-(((2S,3S)-4-((E)-3-((R)-1-carboxy-2-(3-hydroxy-4-oxidophenyl)ethoxy)-3-oxoprop-1-en-1-yl)-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydrobenzofuran-3-carbonyl)oxy)ethyl)-2-hydroxyphenolate
CBNumber: CB7980918
Molecular Formula: C36H28MgO16
Formula Weight: 740.90292
MOL File: 122021-74-3.mol

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magnessium lithospermate B Property

solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
color: Light yellow to light brown
InChIKey: ANUBYMNVOPVATP-OAZHBLANSA-L

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: N2234
Product name: MonomethyllithospermateB
Packaging: 5mg
Price: $450
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb104759
Product name: Monomethyl lithospermate B
Purity: >98%,Standard References Grade
Packaging: 20mg
Price: $569.5
Updated: 2021/12/16

DC Chemicals

Product number: DCD-054
Product name: MonomethyllithospermateB
Purity: >98%,StandardReferencesGrade
Packaging: 20mg
Price: $280
Updated: 2021/12/16

Arctom

Product number: CFN90390
Product name: MagnesiumLithospermateB
Packaging: 5mg
Price: $320
Updated: 2021/12/16

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magnessium lithospermate B Chemical Properties,Usage,Production

Uses

Magnesium Lithospermate B, is a derivative of caffeic acid tetramer and an inhibitor of Na+/K+ ATPase, which can be extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroin?ammation and attenuates neurodegeneration[1][2][3].

in vivo

Magnesium Lithospermate B (2-8 mg/kg; p.o. once daily for 16 d) reduces the renal damage of oxidative stress through reduction of reactive oxygen species in old rats^[1].
Magnesium Lithospermate B (0.5 μg/g; s.c. for 6 weeks) promotes the neurogenesis and improves the memory in PD models^[3].

Animal Model:	Young (5-month-old) and old (20-month-old) specific-pathogen-free male Sprague-Dawley rats^[1]
Dosage:	2, 8 mg/kg
Administration:	P.o. once daily for 16 days
Result:	Reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho-p38, nuclear factor-kappa B p65, cyclooxygenase-2, and inducible nitric oxide synthase. Showed lower levels of senescence-related proteins such as p16, ADP-ribosylation factor 6, p53, and p21.

target

p65 | NF-kB | TGF-β/Smad | ROS | PDGFR

References

[1] Magnesium lithospermate B possesses inhibitory activity on Na+,K+‐ATPase and neuroprotective effects against ischemic stroke
[2] Park CH, et, al. Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging-Induced Renal Inflammation and Senescence via NADPH Oxidase-Mediated Reactive Oxygen Generation. Phytother Res. 2017 May;31(5):721-728. DOI:10.1002/ptr.5789
[3] Quan W, et, al. Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro. J Tradit Chin Med. 2013 Feb; 33(1): 85-91. DOI:10.1016/s0254-6272(13)60106-5
[4] Zhang Z, et, al. Magnesium lithospermate B promotes proliferation and differentiation of neural stem cells in vitro and enhances neurogenesis in vivo. Tissue Cell. 2018 Aug; 53:8-14. DOI:10.1016/j.tice.2018.05.012

magnessium lithospermate B Preparation Products And Raw materials

Raw materials

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122021-74-3, magnessium lithospermate BRelated Search:

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MAGNESIUM LITHOSPERMATE B 98%

Monomethyl lithospermate B

magnessium lithospermate B

magnesium,2-[(E)-3-[3-[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoate

Magnesium Salvianolate B

Magnesium Lithospermate B

Magnesium Lithospermate B, 10 mM in DMSO

Magnesium 4-((R)-2-carboxy-2-(((2S,3S)-4-((E)-3-((R)-1-carboxy-2-(3-hydroxy-4-oxidophenyl)ethoxy)-3-oxoprop-1-en-1-yl)-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydrobenzofuran-3-carbonyl)oxy)ethyl)-2-hydroxyphenolate

122021-74-3

C36H28MgO16

C36H28O16Mg

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract