Ivabradine hydrochloride

Product Name: Ivabradine hydrochloride
CAS No.: 148849-67-6
Chemical Name: Ivabradine hydrochloride
Synonyms: Ivabradine HCl;Procoralan;Ivabradine hydrochlorid;CS-774;S-16257;Corlentor;S 16257-2;2H-3-Benzazepin-2-on;Ivabridine hydracloride;Ivabradine hydrochloride
CBNumber: CB81006694
Molecular Formula: C27H37ClN2O5
Formula Weight: 505.05
MOL File: 148849-67-6.mol

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Ivabradine hydrochloride Property

Melting point:: 193-196?C
alpha: 58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
storage temp.: 2-8°C
solubility: H2O: ≥5mg/mL (warmed)
form: powder
color: white to beige
optical activity: [α]/D +5 to +9°, c = 1 in DMSO
Merck: 14,5247
InChI: InChI=1/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/s3
InChIKey: HLUKNZUABFFNQS-ZMBIFBSDSA-N
SMILES: C([C@H]1CC2=CC(OC)=C(OC)C=C12)N(C)CCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl |&1:1,r|
CAS DataBase Reference: 148849-67-6(CAS DataBase Reference)

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Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HS Code: 2933.79.1500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H400Very toxic to aquatic life
Precautionary statements: P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0281
Product name: Ivabradine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $93.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0281
Product name: Ivabradine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $380
Updated: 2024/03/01

TCI Chemical

Product number: I0847
Product name: Ivabradine Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $771
Updated: 2024/03/01

TCI Chemical

Product number: I0847
Product name: Ivabradine Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 200mg
Price: $229
Updated: 2024/03/01

Cayman Chemical

Product number: 15868
Product name: Ivabradine (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $73
Updated: 2024/03/01

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Ivabradine hydrochloride Chemical Properties,Usage,Production

Description

In an effort to develop angina agents without the unwanted negative inotropic and hypotensive effects associated with b-adrenergic blockers and calcium channel blockers, a new class of heart-rate reducing compounds that act specifically on the sinoatrial (SA) node has been explored. These bradycardic agents interact directly with the pacemaking cell of the SA node and the hyperpolarization- activated If , the primary pacemaking current. Ivabradine has evolved as a specific inhibitor of If current through its contact with f-channels on the intracellular side of the plasma membrane. As a consequence, ivabradine reduces the speed of diastolic depolarization and decreases heart rate. It has been approved for the treatment of chronic stable angina and provides a viable alternative to patients with a contraindication or intolerance of b-blockers. Evaluation is also underway for the potential treatment of ischemic heart disease. Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If current ranged from 6% (0.03 mM) – 80% (10 mM). .

Chemical Properties

White to Off-White Solid

Originator

Servier (France)

Uses

Ivabradine hydrochloride has been used as a potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel (HCN)2 blocker in embryoid body (EB) and rat engineered heart tissue (EHT).

Uses

Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent

Uses

angina therapeutic

Uses

Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal

Definition

ChEBI: A hydrochloride obtained by combining ivabradine with one molar equivalent of hydrochloric acid. Used to treat patients with angina who have intolerance to beta blockers and/or heart failure.

brand name

Procoralan

Biochem/physiol Actions

Ivabradine is used to treat chronic heart failure.

Clinical Use

Symptomatic treatment of chronic stable angina pectoris in patients with sinus rhythm Treatment of mild to severe chronic heart failure

storage

Store at -20°C

Ivabradine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Ivabradine hydrochloride Suppliers

Americas 1 Argentina 1 Brazil 1 Canada 2 China 351 Europe 1 France 1 Germany 2 India 57 Italy 1 Japan 1 Spain 1 Switzerland 1 United Arab Emirates 1 United Kingdom 6 United States 33 Global 461

ORIL INDUSTRIE

Tel: --
Fax: --
Email: cdmo@servier.com
Country: France
ProdList: 2
Advantage: 58

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View Lastest Price from Ivabradine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ivabradine hydrochloride 148849-67-6
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 99%min HPLC
Supply Ability: 50kg
Release date: 2021-08-10

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Ivabradine Hydrochloride 148849-67-6
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-09-19

Hebei Yanxi Chemical Co., Ltd.

Product: Ivabradine hydrochloride 148849-67-6
Price: US $50.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2023-10-20

148849-67-6, Ivabradine hydrochlorideRelated Search:

METSULFURON METHYL Thiophanate-methyl Topotecan hydrochloride Dimethyldimethoxysilane 1,1-Dimethoxyethane Methyl acetate Dimethoxymethane Cefradine Kresoxim-methyl Methyl salicylate 3-Chloropropyltrimethoxysilane Tribenuron methyl 3-Chloropropyltriethoxysilane 3-Aminopropyltriethoxysilane Ivabradine 1-AdaMantanethylaMine Polyethylene Glycol 4,4,5A-TRIMETHYLPERHYDRO-1-BENZOXIREN-2-ONE

Ivabradine HCl

Ivabradine hydrochloride

3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride

Ivabradine hydrochloride, >=99%

IVABRADINE HYDROCHLORIDE-OTHER COMPOUNDSCONTAINING AN UNFUSED PYRAZOLE RING(WHETHER OR NOT HYDROGENATED)IN THE STRUCTUR

Ivabradine hydrochloride, 98%, a If inhibitor

3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride

Corlentor

Procoralan

S-16257

(7,8-Dimethoxy 3-(3-(((1S)-(4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one hydrochloride

2H-3-Benzazepin-2-one, 3-(3-((((7S)-3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride

2H-3-Benzazepin-2-one, 3-(3-(((3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride, (S)-

Ivabridine hydracloride

2H-3-Benzazepin-2-one,3-[3-[[[(7S)-3,4-diMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-,hydrochloride (1:1)

Ivabradine hydrochlorid

3-[3-[[(3,4-diMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)Methyl]MethylaMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-, Monohydrochloride

2H-3-Benzazepin-2-on

Ivabradine HCl (Procoralan)

(S)-3-(3-(((3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)Methyl)(Methyl)aMino)propyl)-7,8-diMethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one hydrochloride

S 16257-2

3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one,hydrochloride (1:1)

lvabradine hydrochloride

CS-774

IvabradineHydrochloride&gt

Ivabradine hydrochloride USP/EP/BP

Ivabradine Hydrochloride Impurities

(S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride

Ivabradine HydrochlorideQ: What is Ivabradine Hydrochloride Q: What is the CAS Number of Ivabradine Hydrochloride Q: What is the storage condition of Ivabradine Hydrochloride Q: What are the applications of Ivabradine Hydrochloride

2-Propen-1-one,1-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyphenyl)-,(6E)-

(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride

Ivabradine Hydrochloride (S)-3-(3-(((4,5-dimethoxy-1,2 dihydrocyclobutabenzen1yl)methyl)(methyl)amino)propyl)-7,8- dimethoxy-4,5-dihydro-1Hbenzo[d]azepin-2(3H)-one hydrochloride

148849-67-6

48849-67-6

148849-54-6

1448849-67-6

C27H37ClN2O5

C27H36N2O5HCl

Chiral Reagents

Heterocycles

API

Cardiovascular APIs

Intermediates & Fine Chemicals

Pharmaceuticals

Inhibitors