ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE
- Product Name
- ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE
- CAS No.
- 77156-78-6
- Chemical Name
- ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE
- Synonyms
- BUTTPARK 20\09-61;ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE;ETHYL 4-HYDROXY-6-METHOXY-3-QUINOLINECARBOXYLATE;ethyl 6-methoxy-4-oxo-1H-quinoline-3-carboxylate;ethyl 6-methoxy-4-hydroxy-3-quinoline-carboxylate;2-ethyl-6-methoxy-4-oxo-1H-quinoline-3-carboxylate;Ethyl 4-hydroxy-6-(methyloxy)-3-quinolinecarboxylate;Ethyl 6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate;Ethyl 1,4-dihydro-6-methoxy-4-oxoquinoline-3-carboxylate;4-Hydroxy-6-methoxy-3-quinolinecarboxylic acid ethyl ester
- CBNumber
- CB8100742
- Molecular Formula
- C13H13NO4
- Formula Weight
- 247.25
- MOL File
- 77156-78-6.mol
ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE Property
- Melting point:
- 280-283℃
- Boiling point:
- 373.2±37.0 °C(Predicted)
- Density
- 1.277
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.72±0.50(Predicted)
- Appearance
- Light brown to brown Solid
- InChI
- InChI=1S/C13H13NO4/c1-3-18-13(16)10-7-14-11-5-4-8(17-2)6-9(11)12(10)15/h4-7H,3H2,1-2H3,(H,14,15)
- InChIKey
- VNGGYIBIGOOVNP-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(OC)=CC=2)C(O)=C(C(OCC)=O)C=1
N-Bromosuccinimide Price
- Product number
- BBO000179
- Product name
- 4-Hydroxy-6-methoxyquinoline-3-carboxylic acid ethyl ester
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $134
- Updated
- 2023/06/20
- Product number
- E945470
- Product name
- Ethyl4-hydroxy-6-methoxyquinoline-3-carboxylate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- E945470
- Product name
- Ethyl4-hydroxy-6-methoxyquinoline-3-carboxylate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4H29-1-2M
- Product name
- Ethyl 1,4-dihydro-6-methoxy-4-oxoquinoline-3-carboxylate
- Packaging
- 1g
- Price
- $192
- Updated
- 2021/12/16
- Product number
- Y3306
- Product name
- Ethyl4-hydroxy-6-methoxyquinoline-3-carboxylate
- Packaging
- 5g
- Price
- $249
- Updated
- 2021/12/16
ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
83507-70-4
77156-78-6
A solution was prepared from diethyl 2-[(4-methoxyanilino)methylene]malonate (CAS: 83507-70-4, 71.4 g, 0.24 mol) in 150 mL of diphenyl ether. The reaction system was placed in a metal bath and slowly heated to 243 °C and maintained at this temperature for 3 hours. During the reaction, 15 mL of liquid was distilled. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently dissolved by adding 250 mL of hexane. After stirring the mixture for 3 hours, a filtration operation was performed. The resulting solid was washed with hexane and dried to give ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate (25.0 g, 0.10 mol, 41% yield), the purity of which meets the requirements for direct use in subsequent reactions. The structure of the product was confirmed by 1H-NMR (CDCl3) and LC-MS: 1H-NMR (CDCl3) δ= 1.28 (t, 3H), 3.85 (s, 3H), 4.21 (q, 2H), 7.34 (dd, 1H), 7.55-7.62 (m, 2H), 8.49 (s, 1H); LC-MS: Rt = 1.17 min ; MS: m/z = 248 [M + 1]+.
References
[1] Patent: WO2006/2047, 2006, A2. Location in patent: Page/Page column 60
[2] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 1 - 16
[3] Organic Process Research and Development, 2014, vol. 18, # 11, p. 1482 - 1491
[4] Tetrahedron Letters, 2017, vol. 58, # 8, p. 794 - 796
[5] Journal of the American Chemical Society, 1946, vol. 68, p. 1204,1206
ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE Suppliers
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- Switzerland
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View Lastest Price from ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE manufacturers
- Product
- ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE 77156-78-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Kg/T
- Release date
- 2019-12-19