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PELITINIB

Product Name
PELITINIB
CAS No.
257933-82-7
Chemical Name
PELITINIB
Synonyms
Pelitinib(EKB-569);PELITINIB;WAY172569;WAY 172569;WAY-172569;WAY-EKB 569;Pelitinib, >=98%;EKB-569 Pelitinib;257933-82-7 PELITINIB;Pelitinib, 10 mM in DMSO
CBNumber
CB81011748
Molecular Formula
C24H23ClFN5O2
Formula Weight
467.92
MOL File
257933-82-7.mol
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PELITINIB Property

Melting point:
173-178°C
Boiling point:
655.5±55.0 °C(Predicted)
Density 
1.34
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
form 
powder
pka
12.23±0.43(Predicted)
color 
white to beige
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2933.59.8000
HazardClass 
6.1
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0197
Product name
Pelitinib
Purity
≥98% (HPLC)
Packaging
5mg
Price
$149
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0197
Product name
Pelitinib
Purity
≥98% (HPLC)
Packaging
25mg
Price
$594
Updated
2024/03/01
TCI Chemical
Product number
P2529
Product name
Pelitinib
Purity
>97.0%(HPLC)
Packaging
25mg
Price
$143
Updated
2024/03/01
TCI Chemical
Product number
P2529
Product name
Pelitinib
Purity
>97.0%(HPLC)
Packaging
100mg
Price
$389
Updated
2024/03/01
Cayman Chemical
Product number
15627
Product name
Pelitinib
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
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PELITINIB Chemical Properties,Usage,Production

Description

Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM). It inhibits HER2 with a much weaker potency (IC50 = 1.2 μM). By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC50s = ~2 μM).

Chemical Properties

Off-White Solid

Uses

Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.

Uses

An EGFR inhibitor

Uses

Labelled Pelitinib (P218702). A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer.

Definition

ChEBI: Pelitinib is an aminoquinoline, a nitrile, a monocarboxylic acid amide and a member of monochlorobenzenes. It has a role as a protein kinase inhibitor.

target

EGFR

storage

Store at -20°C

References

[1] torrance cj, jackson pe, montgomery e, kinzler kw, vogelstein b, wissner a, nunes m, frost p, discafani cm. combinatorial chemoprevention of intestinal neoplasia. nat med. 2000 sep;6(9):1024-8.
[2] nunes m, shi c, greenberger lm. phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase b, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, ekb-569, in tumor cells and normal human keratinocytes. mol cancer ther. 2004 jan;3(1):21-7.

PELITINIB Preparation Products And Raw materials

Raw materials

Preparation Products

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PELITINIB Suppliers

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View Lastest Price from PELITINIB manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Pelitinib 257933-82-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Pelitinib 257933-82-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
PELITINIB 257933-82-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-07-09

257933-82-7, PELITINIBRelated Search:

Peficitinib LOXO-101 Ceritinib (LDK378) Lapatinib Sunitinib Ibrutinib PD168393 PI-103 WZ4002 AST-1306 AZD-9291 Canertinib PELITINIB

  • PELITINIB
  • 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-
  • (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
  • WAY-EKB 569
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  • (E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
  • Pelitinib(EKB-569)
  • (2e)-n-(4-((3-chloro-4-fluorophenyl)aMino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(diMethylaMino)-2-butenaMide pelitinib
  • N-[4-(3-Chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)-2(E)-but·Namide
  • EKB-569 Pelitinib
  • Pelitinib (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
  • Pelitinib, >=98%
  • (E)-N-(4-(3-Chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-
  • 257933-82-7 PELITINIB
  • WAY 172569
  • WAY172569
  • WAY-172569
  • Pelitinib (EKB-569), Irreversible EGFR inhibitor
  • Pelitinib, 10 mM in DMSO
  • 257933-82-7
  • C24H23ClFN5O2
  • C24H17D6ClFN5O2
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Tyrosine Kinase Inhibitors
  • pyridine
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  • API
  • Aromatics
  • Heterocycles
  • Isotope Labelled Compounds