PELITINIB

ChemicalBook > CAS DataBase List > PELITINIB

Product Name: PELITINIB
CAS No.: 257933-82-7
Chemical Name: PELITINIB
Synonyms: Pelitinib(EKB-569);PELITINIB;WAY172569;WAY 172569;WAY-172569;WAY-EKB 569;Pelitinib, >=98%;EKB-569 Pelitinib;257933-82-7 PELITINIB;PELITINIB (EKB-569;WAY-EKB 569)
CBNumber: CB81011748
Molecular Formula: C24H23ClFN5O2
Formula Weight: 467.92
MOL File: 257933-82-7.mol

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PELITINIB Property

Melting point:: 173-178°C
Boiling point:: 655.5±55.0 °C(Predicted)
Density: 1.34
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
pka: 12.23±0.43(Predicted)
color: white to beige

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 2933.59.8000
HazardClass: 6.1
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0197
Product name: Pelitinib
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $149
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0197
Product name: Pelitinib
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $594
Updated: 2024/03/01

TCI Chemical

Product number: P2529
Product name: Pelitinib
Purity: >97.0%(HPLC)
Packaging: 25mg
Price: $143
Updated: 2024/03/01

TCI Chemical

Product number: P2529
Product name: Pelitinib
Purity: >97.0%(HPLC)
Packaging: 100mg
Price: $389
Updated: 2024/03/01

Cayman Chemical

Product number: 15627
Product name: Pelitinib
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

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PELITINIB Chemical Properties,Usage,Production

Description

Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC₅₀ = 39 nM). It inhibits HER2 with a much weaker potency (IC₅₀ = 1.2 μM). By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC₅₀s = ~2 μM).

Chemical Properties

Off-White Solid

Uses

Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.

Uses

An EGFR inhibitor

Uses

Labelled Pelitinib (P218702). A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer.

Definition

ChEBI: Pelitinib is an aminoquinoline, a nitrile, a monocarboxylic acid amide and a member of monochlorobenzenes. It has a role as a protein kinase inhibitor.

target

EGFR

storage

Store at -20°C

References

[1] torrance cj, jackson pe, montgomery e, kinzler kw, vogelstein b, wissner a, nunes m, frost p, discafani cm. combinatorial chemoprevention of intestinal neoplasia. nat med. 2000 sep;6(9):1024-8.
[2] nunes m, shi c, greenberger lm. phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase b, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, ekb-569, in tumor cells and normal human keratinocytes. mol cancer ther. 2004 jan;3(1):21-7.

PELITINIB Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PELITINIB manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Pelitinib 257933-82-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Pelitinib 257933-82-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: PELITINIB 257933-82-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-07-09

257933-82-7, PELITINIBRelated Search:

Peficitinib LOXO-101 Ceritinib (LDK378) Lapatinib Sunitinib Ibrutinib PD168393 PI-103 WZ4002 AST-1306 AZD-9291 Canertinib PELITINIB

PELITINIB

2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-

(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide

WAY-EKB 569

PELITINIB (EKB-569;WAY-EKB 569)

EKB-569; WAY-EKB 569; EKB569; EKB 569

(2E)-N-{4-[(3-chloro-4-fluorophenyl)aMino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(diMethylaMino)but-2-enaMide

(E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide

Pelitinib(EKB-569)

(2e)-n-(4-((3-chloro-4-fluorophenyl)aMino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(diMethylaMino)-2-butenaMide pelitinib

N-[4-(3-Chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)-2(E)-but·Namide

EKB-569 Pelitinib

Pelitinib (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide

Pelitinib, >=98%

(E)-N-(4-(3-Chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-

257933-82-7 PELITINIB

WAY 172569

WAY172569

WAY-172569

257933-82-7

C24H23ClFN5O2

C24H17D6ClFN5O2

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Tyrosine Kinase Inhibitors

pyridine

All Inhibitors

API

Aromatics

Heterocycles

Isotope Labelled Compounds