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Pirmenol

Product Name
Pirmenol
CAS No.
68252-19-7
Chemical Name
Pirmenol
Synonyms
(±)-Pirmenol;Pirmenol (Cl-845);Pirmenol, 10 mM in DMSO;2-Pyridinemethanol, a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-, cis-;rel-4-((2S,6R)-2,6-Dimethylpiperidin-1-yl)-1-phenyl-1-(pyridin-2-yl)butan-1-ol;2-Pyridinemethanol, a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-, cis-(+-)-;2-Pyridinemethanol, α-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-α-phenyl-, rel-;2-Pyridinemethanol, a-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-a-phenyl-, rel- (9CI)
CBNumber
CB81116681
Molecular Formula
C22H30N2O
Formula Weight
338.49
MOL File
68252-19-7.mol
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Pirmenol Property

Melting point:
70-71°
Boiling point:
499.6±45.0 °C(Predicted)
Density 
1.046±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 2mg/mL,DMSO: 5mg/mL,Ethanol: 10mg/mL,Ethanol:PBS (pH 7.2) (1:5): 0.16mg/mL
form 
A solid
pka
12.66±0.29(Predicted)
color 
White to v. dark grey
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3555
Product name
Pirmenol
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$79.51
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3555
Product name
Pirmenol
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$269
Updated
2025/07/31
Cayman Chemical
Product number
29042
Product name
Pirmenol
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
29042
Product name
Pirmenol
Packaging
25mg
Price
$573
Updated
2024/03/01
Cayman Chemical
Product number
29042
Product name
Pirmenol
Packaging
5mg
Price
$151
Updated
2024/03/01
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Pirmenol Chemical Properties,Usage,Production

Uses

Cardiac depressant (anti-arrhythmic).

Definition

ChEBI: Pirmenol is a racemate.

brand name

Pirmavar (Parke-Davis).

Biological Activity

Pirmenol is an antiarrhythmic agent class Ia th at exhibit long half-life and low toxicities. Pirmenol suppresses premature ventricular contractions in human studies.

in vivo

Pirmenol (2.5 and 5 mg/kg, p.o.) is effective against the arrhythmias in conscious, coronary artery ligated dogs[4].
Pirmenol (rats) shows LD50s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.)[2].
Pirmenol (mice) shows LD50s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.)[2].

Animal Model:Conscious, coronary artery ligated dogs[4]
Dosage:Oral administration (p.o.)
Administration:2.5 and 5 mg/kg
Result:Restored normal sinus rhythm, and showed a long duration of activity, wide safety margin.

Pirmenol Preparation Products And Raw materials

Raw materials

Preparation Products

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Pirmenol Suppliers

China 31 United Kingdom 1 United States 6 Global 38
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47

68252-19-7, PirmenolRelated Search:

Pirmenol hydrochloride 1-PHENYL-1-(2-PYRIDYL)ETHANOL 4-DIISOPROPYLAMINO-1-BUTANOL Pirmenol

  • 2-Pyridinemethanol, a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-, cis-
  • 2-Pyridinemethanol, a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-, cis-(+-)-
  • 2-Pyridinemethanol, a-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-a-phenyl-, rel- (9CI)
  • 2-Pyridinemethanol, α-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-α-phenyl-, rel-
  • Pirmenol (Cl-845)
  • rel-4-((2S,6R)-2,6-Dimethylpiperidin-1-yl)-1-phenyl-1-(pyridin-2-yl)butan-1-ol
  • Pirmenol, 10 mM in DMSO
  • (±)-Pirmenol
  • 68252-19-7