METHYLLYCACONITINE CITRATE

Product Name: METHYLLYCACONITINE CITRATE
CAS No.: 112825-05-5
Chemical Name: METHYLLYCACONITINE CITRATE
Synonyms: MLA;METHYLLYCACONITINE CITRATE;Methyllycaconitine citrate salt;MLA (Methyllycaconitine Citrate);Cytotoxic T-Lymphocyte-Associated Antigen 8;Methyllycaconitine citrate (MLA), alpha7 Nicotinic receptor antagonist;INTERLEUKIN-17A; IL-17; IL-17A; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 8; CTLA-8; IL17A; CTLA8; IL17;[1A,4(S),6B,14A,16B]-20-ETHYL-1,6,14,16-TETRAMETHOXY-4-[[[2-(3-METHYL-2,5-DIOXO-1-PYRROLIDINYL)BENZOYL]OXY]METHYL]ACONITANE-7,8-DIOL CITRATE;[1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate salt;[1ALPHA,4(S),6BETA,14ALPHA,16BETA]-20-ETHYL-1,6,14,16-TETRAMETHOXY-4[[[2-(3-METHYL-2,5-DIOXO-1-PYRROLIDINYL)BENZOYL]OXY]METHYL]-ACONITANE-7,8-DIOL CITRATE
CBNumber: CB8113766
Molecular Formula: C43H58N2O17
Formula Weight: 874.92
MOL File: 112825-05-5.mol

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METHYLLYCACONITINE CITRATE Property

storage temp.: −20°C
solubility: H₂O: 42 mg/mL
form: solid
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M168
Product name: Methyllycaconitine citrate salt
Purity: from Delphinium brownii seeds, ≥96% (HPLC)
Packaging: 5mg
Price: $114
Updated: 2024/03/01

Sigma-Aldrich

Product number: M168
Product name: Methyllycaconitine citrate salt
Purity: from Delphinium brownii seeds, ≥96% (HPLC)
Packaging: 25mg
Price: $404
Updated: 2024/03/01

Tocris

Product number: 1029
Product name: Methyllycaconitinecitrate
Packaging: 25
Price: $413
Updated: 2021/12/16

Tocris

Product number: 1029
Product name: Methyllycaconitinecitrate
Packaging: 5
Price: $95
Updated: 2021/12/16

Usbiological

Product number: 255801
Product name: Methyllycaconitine Citrate
Packaging: 5mg
Price: $339
Updated: 2021/12/16

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METHYLLYCACONITINE CITRATE Chemical Properties,Usage,Production

Uses

Methyllycaconitine citrate salt has been used as an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist:

to study its effects on inflammatory response in rats post nicotine treatment
to block the activity of galantamine
to study its effects on the hepatic branch of the vagus nerve (hVNS) in rats

Biological Activity

methyllycaconitine citrate(mla) is an antagonist of α7-containing neuronal nicotinic acetylcholine receptors (nachrs; ki = 1.4 nm)[1,2].mla inhibits the decreased cell viability induced by aβ25-35, pretreatment with 5 and 10 μm. aβ25-35 treatment increases lc3-ii levels, which is inhibited by administration of methyllycaconitine citrate. mla also inhibits aβ-induced autophagosome accumulation in sh-sy5y cells[3].mla inhibits methamphetamine(meth)-induced climbing behavior by 50%. mla prevents a decrease in striatal synaptosome dopamine (da) uptake, mla significantly attenuates meth-induced neurotoxicity at 72 h post-treatment. mla fully prevents microglial activation at 24 h post-treatment and tending to confirm its neuroprotective activity[4].[1]. kalappa b i, sun f, johnson s r, et al. a positive allosteric modulator of α7 nachrs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia. brit.j.pharmacol, 2013, 169(8): 1862-1878.[2]. ward j m, cockcroft v b, lunt g g, et al. methyllycaconitine: a selective probe for neuronal α-bungarotoxin binding sites. febs lett, 1990, 270(1-2): 45-48 .[3]. zheng x, et al. methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in sh-sy5y cells. plos one, 2014, 9(10): e111536.[4]. escubedo e, et al. methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors. j pharmacol exp ther, 2005, 315(2): 658-67.

Biochem/physiol Actions

Methyllycaconitine (MLA) is an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist. It is a norditerpenoid alkaloid synthesized by several species of Delphinium. MLA binds to the binding site of neuronal α-bungarotoxin. Low doses of MLA are associated with improvement of cognition in animals.

METHYLLYCACONITINE CITRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYLLYCACONITINE CITRATE Suppliers

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112825-05-5, METHYLLYCACONITINE CITRATERelated Search:

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METHYLLYCACONITINE CITRATE

[1ALPHA,4(S),6BETA,14ALPHA,16BETA]-20-ETHYL-1,6,14,16-TETRAMETHOXY-4[[[2-(3-METHYL-2,5-DIOXO-1-PYRROLIDINYL)BENZOYL]OXY]METHYL]-ACONITANE-7,8-DIOL CITRATE

[1A,4(S),6B,14A,16B]-20-ETHYL-1,6,14,16-TETRAMETHOXY-4-[[[2-(3-METHYL-2,5-DIOXO-1-PYRROLIDINYL)BENZOYL]OXY]METHYL]ACONITANE-7,8-DIOL CITRATE

MLA

[1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate salt

Methyllycaconitine citrate salt

Cytotoxic T-Lymphocyte-Associated Antigen 8

INTERLEUKIN-17A; IL-17; IL-17A; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 8; CTLA-8; IL17A; CTLA8; IL17

MLA (Methyllycaconitine Citrate)

Aconitane-7,8-diol, 20-ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]-, [1α,4(S),6β,14α,16β]-, 2-hydroxy-1,2,3-propanetricarboxylate (salt) (9CI)

Methyllycaconitine citrate (MLA), alpha7 Nicotinic receptor antagonist

112825-05-5