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(R)-3-phenylmorpholine

Product Name
(R)-3-phenylmorpholine
CAS No.
74572-03-5
Chemical Name
(R)-3-phenylmorpholine
Synonyms
3-Phenylmorpholine;(R)-3-phenylmorpholine;(3R)-3-phenylmorpholine;(3R)-3-Phenyl-Morpholine HCl;Morpholine, 3-phenyl-, (3R)-
CBNumber
CB81152786
Molecular Formula
C10H13NO
Formula Weight
163.22
MOL File
74572-03-5.mol
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(R)-3-phenylmorpholine Property

storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P335590
Product name
(R)-3-Phenylmorpholine
Packaging
5G
Price
$690
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
41999
Product name
(R)-3-Phenylmorpholine
Packaging
1g
Price
$675
Updated
2021/12/16
AK Scientific
Product number
1581AC
Product name
(R)-3-Phenylmorpholine
Packaging
100mg
Price
$151
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0032119
Product name
(R)-3-PHENYLMORPHOLINE
Purity
95.00%
Packaging
250MG
Price
$226.8
Updated
2021/12/16
ACHEMBLOCK
Product number
B-1095
Product name
(R)-3-Phenyl-morpholine
Purity
95%
Packaging
1G
Price
$250
Updated
2021/12/16
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(R)-3-phenylmorpholine Chemical Properties,Usage,Production

Uses

(R)-3-Phenylmorpholine is used in the synthetic preparation of phosphoinositide kinase inhibitors.

Synthesis

192815-71-7

138713-44-7

General procedure: lithium aluminum hydride (3.55 g, 93.8 mmol) was added batchwise to a stirred solution of (R)-5-phenylmorpholin-3-one (4.15 g, 23.4 mmol) in anhydrous THF (30 mL) under the protection of nitrogen, keeping the reaction temperature at 0 °C. Subsequently, the reaction mixture was slowly warmed up to 45 °C and stirred continuously at this temperature for 5 hours. Upon completion of the reaction, the reaction was carefully quenched with saturated aqueous sodium sulfate solution. Ethyl acetate was added to the aqueous phase mixture and stirring was continued for 10 minutes. The resulting suspension was filtered through diatomaceous earth and the filtrate was collected and dried with anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was dried well to give 615 mg of the target product 3-phenylmorpholine. The product was characterized by NMR (300 MHz, CDCl3): δ 3.00 (d, J = 11.4 Hz, 1H), 3.07-3.17 (m, 1H), 3.40 (t, J = 10.5 Hz, 1H), 3.62-3.70 (m, 1H), 3.80-3.95 (m, 3H), 7.27-7.41 (m, 5H).

References

[1] ACS Combinatorial Science, 2016, vol. 18, # 9, p. 569 - 574
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 15, p. 4316 - 4320
[3] Patent: WO2013/49719, 2013, A1. Location in patent: Paragraph 00183
[4] Patent: WO2018/116285, 2018, A1. Location in patent: Page/Page column 26-27

(R)-3-phenylmorpholine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-3-phenylmorpholine Suppliers

Canada 1 China 76 India 2 United States 5 Global 84
ForeChem (Nantong) Technology Co.,Ltd.
Tel
513-85982855 18921614129
Fax
051385915507
Email
sales@xianxingpharm.com
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China
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2986
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
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China
ProdList
18207
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66
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
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China
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shanghai Rainbow MediTech.Co.Ltd.
Tel
021-64968085,64968086-5815,5812; 13472757003
Fax
+86 21 64968087
Email
xiaoxia.zeng@rainbowpharma.cn
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China
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Shijiazhuang Lickon PharmaTech Co., Ltd.
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031185291771 13832391721
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0311-67305698
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yaofeng2005@163.com
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China
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Amatek Scientific Co. Ltd.
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0512-56316828 4008675858
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+86-512-56316826
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sales@amateksci.com
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China
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Shanghai Balmxy Pharmaceutical Co., Ltd
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021-24206007 13764915196
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86-021-23027023
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sales@balmxy.com
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China
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Tianjin Anhao Biological Technology Co., Ltd.
Tel
Email
sales@ahpharmatech.com
Country
China
ProdList
5734
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LABTER PHARMATECH(BEIJING) CO.,LTD
Tel
010-56330744 18310155299
Fax
010-56330744
Email
sales@labter.com.cn
Country
China
ProdList
20000
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55
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
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View Lastest Price from (R)-3-phenylmorpholine manufacturers

Career Henan Chemical Co
Product
(R)-3-phenylmorpholine 74572-03-5
Price
US $5.00/KG
Min. Order
1KG
Purity
95%-98%
Supply Ability
100kg
Release date
2019-09-04

74572-03-5, (R)-3-phenylmorpholineRelated Search:

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  • (R)-3-phenylmorpholine
  • 3-Phenylmorpholine
  • Morpholine, 3-phenyl-, (3R)-
  • (3R)-3-Phenyl-Morpholine HCl
  • (3R)-3-phenylmorpholine
  • 74572-03-5
  • pharmacetical