(R)-3-phenylmorpholine
- Product Name
- (R)-3-phenylmorpholine
- CAS No.
- 74572-03-5
- Chemical Name
- (R)-3-phenylmorpholine
- Synonyms
- 3-Phenylmorpholine;(R)-3-phenylmorpholine;(3R)-3-phenylmorpholine;(3R)-3-Phenyl-Morpholine HCl;Morpholine, 3-phenyl-, (3R)-
- CBNumber
- CB81152786
- Molecular Formula
- C10H13NO
- Formula Weight
- 163.22
- MOL File
- 74572-03-5.mol
(R)-3-phenylmorpholine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P335590
- Product name
- (R)-3-Phenylmorpholine
- Packaging
- 5G
- Price
- $690
- Updated
- 2021/12/16
- Product number
- 1581AC
- Product name
- (R)-3-Phenylmorpholine
- Packaging
- 100mg
- Price
- $151
- Updated
- 2021/12/16
- Product number
- CCH0032119
- Product name
- (R)-3-PHENYLMORPHOLINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $226.8
- Updated
- 2021/12/16
- Product number
- 41999
- Product name
- (R)-3-Phenylmorpholine
- Packaging
- 1g
- Price
- $675
- Updated
- 2021/12/16
- Product number
- A139737
- Product name
- (R)-3-Phenylmorpholine
- Purity
- 98%
- Packaging
- 100mg
- Price
- $72
- Updated
- 2021/12/16
(R)-3-phenylmorpholine Chemical Properties,Usage,Production
Uses
(R)-3-Phenylmorpholine is used in the synthetic preparation of phosphoinositide kinase inhibitors.
Synthesis
192815-71-7
138713-44-7
General procedure: lithium aluminum hydride (3.55 g, 93.8 mmol) was added batchwise to a stirred solution of (R)-5-phenylmorpholin-3-one (4.15 g, 23.4 mmol) in anhydrous THF (30 mL) under the protection of nitrogen, keeping the reaction temperature at 0 °C. Subsequently, the reaction mixture was slowly warmed up to 45 °C and stirred continuously at this temperature for 5 hours. Upon completion of the reaction, the reaction was carefully quenched with saturated aqueous sodium sulfate solution. Ethyl acetate was added to the aqueous phase mixture and stirring was continued for 10 minutes. The resulting suspension was filtered through diatomaceous earth and the filtrate was collected and dried with anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was dried well to give 615 mg of the target product 3-phenylmorpholine. The product was characterized by NMR (300 MHz, CDCl3): δ 3.00 (d, J = 11.4 Hz, 1H), 3.07-3.17 (m, 1H), 3.40 (t, J = 10.5 Hz, 1H), 3.62-3.70 (m, 1H), 3.80-3.95 (m, 3H), 7.27-7.41 (m, 5H).
References
[1] ACS Combinatorial Science, 2016, vol. 18, # 9, p. 569 - 574
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 15, p. 4316 - 4320
[3] Patent: WO2013/49719, 2013, A1. Location in patent: Paragraph 00183
[4] Patent: WO2018/116285, 2018, A1. Location in patent: Page/Page column 26-27
(R)-3-phenylmorpholine Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-3-phenylmorpholine Suppliers
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View Lastest Price from (R)-3-phenylmorpholine manufacturers
- Product
- (R)-3-phenylmorpholine 74572-03-5
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 95%-98%
- Supply Ability
- 100kg
- Release date
- 2019-09-04