ChemicalBook > CAS DataBase List > 1-(2-N-Boc-Aminoethyl)piperazine

1-(2-N-Boc-Aminoethyl)piperazine

Product Name
1-(2-N-Boc-Aminoethyl)piperazine
CAS No.
140447-78-5
Chemical Name
1-(2-N-Boc-Aminoethyl)piperazine
Synonyms
1-(2-BOC-AMIN;BUTTPARK 90\06-02;TIMTEC-BB SBB011604;ASINEX-REAG BAS 07746391;1-(2-BOC-AMINOETHYL)PIPERAZINE;1-(2-N-BOC-AMINOETHYL)PIPERAZINE;1-(2-N-BOC-AMINOETHYL)PIPERAZINE 97%;1-2-N-Boc-(aminoethyl)-piperazine, 97%;tert-Butyl 2-piperazin-1-ylethylcarbamate;140447-78-5 1-(2-N-Boc-Aminoethyl)piperazine
CBNumber
CB8117926
Molecular Formula
C11H23N3O2
Formula Weight
229.32
MOL File
140447-78-5.mol
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1-(2-N-Boc-Aminoethyl)piperazine Property

Boiling point:
357.2±27.0 °C(Predicted)
Density 
1.014±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
form 
solid
pka
12.74±0.46(Predicted)
color 
White to off-white
InChI
InChI=1S/C11H23N3O2/c1-11(2,3)16-10(15)13-6-9-14-7-4-12-5-8-14/h12H,4-9H2,1-3H3,(H,13,15)
InChIKey
VPOIPCJBJNWHSJ-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)NCCN1CCNCC1
CAS DataBase Reference
140447-78-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS005401
Product name
1-(2-<I>N</I>-Boc-aminoethyl)piperazine
Purity
Aldrich<SUP>CPR</SUP>
Packaging
100 mg
Price
$73.1
Updated
2025/07/31
Sigma-Aldrich
Product number
CDS005401
Product name
1-(2-N-Boc-aminoethyl)piperazine
Purity
AldrichCPR
Packaging
100MG
Price
$68.1
Updated
2023/06/20
TRC
Product number
B630208
Product name
1-[2-(Boc-amino)ethyl]piperazine
Packaging
250mg
Price
$40
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140740
Product name
tert-Butyl (2-(piperazin-1-yl)ethyl)carbamate
Packaging
500mg
Price
$50
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-EY
Product name
tert-Butyl N-[2-(piperazin-1-yl)ethyl]carbamate
Purity
98.0%
Packaging
250mg
Price
$50
Updated
2021/12/16
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1-(2-N-Boc-Aminoethyl)piperazine Chemical Properties,Usage,Production

Uses

1-[2-(Boc-amino)ethyl]piperazine is used in preparation of dihydropyrimidine derivatives as bifunctional degraders for treatment and prophylaxis of target protein-mediated diseases.

Synthesis

500013-42-3

140447-78-5

The general procedure for the synthesis of 1-(N-Boc-aminoethyl)piperazine from 1-CBZ-4-(BOC-aminoethyl)piperazine was as follows: hydrogen was vented into a degassed solution of benzyl 4-(2-(tert-butoxycarbonylamino)ethyl)piperazine-1-carboxylate (2.60 g, 7.16 mmol) containing 10% palladium carbon (500 mg) in methanol (50 ml), the reaction lasted for 2 hours. After completion of the reaction, the mixture was filtered through Celite. The filtrate was concentrated under vacuum to give a yellow colloidal product which was identified as tert-butyl 2-(1-piperazinyl)ethylcarbamate (1.60 g, 97% yield).

References

[1] Patent: EP1449844, 2004, A1. Location in patent: Page 34
[2] Organic and Biomolecular Chemistry, 2015, vol. 13, # 18, p. 5147 - 5157

1-(2-N-Boc-Aminoethyl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(2-N-Boc-Aminoethyl)piperazine manufacturers

Career Henan Chemical Co
Product
1-(2-N-Boc-Aminoethyl)piperazine 140447-78-5
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-29

140447-78-5, 1-(2-N-Boc-Aminoethyl)piperazineRelated Search:

tert-Butyl carbazate BUTYL OLEATE N-Aminoethylpiperazine Ethyl acetate tert-Butyl acetate Diethylene glycol monobutyl ether 2-Ethylhexyl ferulate Butyl acetate tert-Butyl carbamate Cyhalofop-butyl Urethane tert-Butanol Tris(trimethylsilyl)phosphate 1,2-Dimethylhydrazine Dihydrochloride tert-Butyl glycinate tert-Butyl 4-aminobenzoate 2-Methylpiperazine 2-Butoxyethanol

  • BUTTPARK 90\06-02
  • ASINEX-REAG BAS 07746391
  • (2-PIPERAZIN-1-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
  • 1-(2-BOC-AMINOETHYL)PIPERAZINE
  • 1-(2-N-BOC-AMINOETHYL)PIPERAZINE
  • tert-Butyl 2-piperazin-1-ylethylcarbamate
  • Carbamic acid, N-[2-(1-piperazinyl)ethyl]-, 1,1-dimethylethyl ester
  • TIMTEC-BB SBB011604
  • 1-(2-N-BOC-AMINOETHYL)PIPERAZINE 97%
  • 1-(2-BOC-AMIN
  • tert-Butyl N-[2-(piperazin-1-yl)ethyl]carbamate
  • 1-(2-N-Boc-Aminoethyl)piperazine ISO 9001：2015 REACH
  • 140447-78-5 1-(2-N-Boc-Aminoethyl)piperazine
  • 1,1-Dimethylethyl N-[2-(1-piperazinyl)ethyl]carbamate
  • Carbamic acid, <i>N</i>-[2-(1-piperazinyl)ethyl]-, 1,1-dimethylethyl ester
  • 1-2-N-Boc-(aminoethyl)-piperazine, 97%
  • 1-(2-N-Boc-aminoethyl)piperazine, CAS 140447-78-5
  • 140447-78-5
  • pharmacetical