ChemicalBook > CAS DataBase List > Vanoxerine

Vanoxerine

Product Name
Vanoxerine
CAS No.
67469-69-6
Chemical Name
Vanoxerine
Synonyms
Vanoxerine free base;1-(2-(di(4-fluorophenyl)-methoxy)-ethyl)-4-(3-phenylpropyl)piperazine;Piperazine, 1-[2-[bis(4-fluorophenyl)Methoxy]ethyl]-4-(3-phenylpropyl)-
CBNumber
CB81180039
Molecular Formula
C28H32F2N2O
Formula Weight
450.56
MOL File
67469-69-6.mol
More
Less

Vanoxerine Property

Boiling point:
542.7±50.0 °C(Predicted)
Density 
1.135±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
7.55±0.10(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

ApexBio Technology
Product number
B3249
Product name
Vanoxerine
Packaging
25mg
Price
$156
Updated
2021/12/16
AvaChem
Product number
2889B
Product name
Vanoxerine
Packaging
10mg
Price
$45
Updated
2021/12/16
CSNpharm
Product number
CSN12187
Product name
Vanoxerine
Packaging
10mg
Price
$51
Updated
2021/12/16
AvaChem
Product number
2889B
Product name
Vanoxerine
Packaging
25mg
Price
$55
Updated
2021/12/16
AvaChem
Product number
2889B
Product name
Vanoxerine
Packaging
100mg
Price
$135
Updated
2021/12/16
More
Less

Vanoxerine Chemical Properties,Usage,Production

Definition

ChEBI: Vanoxerine is an N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration. It has a role as a dopamine uptake inhibitor. It is a N-alkylpiperazine, an organofluorine compound, a tertiary amino compound and an ether. It is a conjugate base of a vanoxerine(2+).

Biological Activity

vanoxerine is an antagonist of dopamine transporter (dat1) with ki value of 16.9nm [1].as an antagonist of dat, vanoxerine is developed for treatment of parkinson's disease and depression but has no effect on these diseases. vanoxerine is also found to have desirable cardiac antiarrhythmic properties. it is a blocker of cardiac herg (hkv11.1) with ic50 value of 0.84nm. it also blocks the ica,l and hnav1.5 channel with ic50 values of 320nm and 830nm, respectively. vanoxerine does not significantly prolong purkinje fiber apd60 and apd90 and has no significant effect on qt or tdr. further, the

References

[1] giros b, el mestikawy s, godinot n, zheng k, han h, yang-feng t, caron mg. cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. mol pharmacol. 1992 sep;42(3):383-90.
[2] lacerda ae, kuryshev ya, yan gx, waldo al, brown am. vanoxerine: cellular mechanism of a new antiarrhythmic. j cardiovasc electrophysiol. 2010 mar;21(3):301-10.

Vanoxerine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Vanoxerine Suppliers

Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58

67469-69-6, VanoxerineRelated Search:


  • Piperazine, 1-[2-[bis(4-fluorophenyl)Methoxy]ethyl]-4-(3-phenylpropyl)-
  • 1-(2-(di(4-fluorophenyl)-methoxy)-ethyl)-4-(3-phenylpropyl)piperazine
  • Vanoxerine free base
  • 67469-69-6
  • C28H32F2N2O