BOC-MET-OL

Product Name: BOC-MET-OL
CAS No.: 51372-93-1
Chemical Name: BOC-MET-OL
Synonyms: BOC-MET-OL;BOC-D-MET-OL;Boc-L-Met-OL;BOC-METHIONINOL;BOC-L-METHIONINOL;N-BOC-L-METHIONINOL;BOC-MET-OL USP/EP/BP;N-ALPHA-T-BOC-L-METHIONINOL;N-T-BUTOXYCARBONYL-L-METHIONINOL;N-(tert-Butoxycarbonyl)-L-Methioninol
CBNumber: CB8118004
Molecular Formula: C10H21NO3S
Formula Weight: 235.34
MOL File: 51372-93-1.mol

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BOC-MET-OL Property

Melting point:: 48.0 to 52.0 °C
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder to crystal
color: White to Almost white

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS020096
Product name: N-(tert-Butoxybutoxycarbonyl)-L-methioninol
Purity: Aldrich
Packaging: 100mg
Price: $68.1
Updated: 2023/06/20

TCI Chemical

Product number: B4283
Product name: N-(tert-Butoxycarbonyl)-L-methioninol
Purity: >95.0%(GC)
Packaging: 1g
Price: $35
Updated: 2025/07/31

TCI Chemical

Product number: B4283
Product name: N-(tert-Butoxycarbonyl)-L-methioninol
Purity: >95.0%(GC)
Packaging: 5g
Price: $106
Updated: 2025/07/31

Usbiological

Product number: 236443
Product name: Boc-L-methioninol
Packaging: 1g
Price: $229
Updated: 2021/12/16

Usbiological

Product number: 264779
Product name: Boc-L-methioninol
Packaging: 500mg
Price: $333
Updated: 2021/12/16

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BOC-MET-OL Chemical Properties,Usage,Production

Uses

peptide synthesis

Synthesis

2488-15-5

51372-93-1

General procedure for the synthesis of (S)-2-(tert-butoxycarbonylamino)-4-methylthio-1-butanol from Boc-L-methionine: Boc-L-methionine (49.8 g, 0.5 mol) and 250 mL of tetrahydrofuran (THF) were added to a 500 mL three-neck flask. The reaction mixture was cooled to 0-5 °C in an ice-salt bath with stirring. Sodium borohydride (19 g, 0.5 mol) was slowly added, followed by 50 mL of methanol. Next, 100 mL of tetrahydrofuran solution of iodine (127 g, 0.5 mol) was added dropwise. The reaction system was heated to reflux and the reaction was continuously stirred for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of raw materials, the reaction mixture was cooled in an ice water bath. Saturated ammonium chloride solution was added to quench the reaction. After approximately 100 mL of THF was removed by evaporation using a reduced pressure evaporator, the residue was extracted with ethyl acetate (300 mL). The organic layer was washed sequentially with dilute hydrochloric acid, saturated sodium bicarbonate solution and saturated sodium chloride solution. After drying with anhydrous sodium sulfate, the crude product (120 g) was concentrated to give an oil. The crude product was purified by column chromatography to give the purified product (97.5 g) in 85% yield. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and mass spectrometry (MS): 1H NMR δ 11.64 (br, 1H), 6.85 (br, 1H), 4.55-4.48 (m, 1H), 2.53 (t, J = 4.9 Hz, 2H), 3.44 (s, 3H), 2.05 (s, 3H), 2.02- 1.87 (m, 2H), 1.48 (s, 9H); MS (M + + 1): 236.

References

[1] Antimicrobial Agents and Chemotherapy, 2017, vol. 61, # 3,
[2] Patent: EP2647624, 2013, A1. Location in patent: Paragraph 0059; 0060
[3] Patent: US2013/281695, 2013, A1. Location in patent: Paragraph 0108-0110
[4] Organic Letters, 2005, vol. 7, # 5, p. 847 - 849
[5] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 5, p. 1921 - 1924

BOC-MET-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-MET-OL Suppliers

Americas 1 China 89 Europe 1 Germany 1 India 5 Japan 2 Switzerland 1 United Kingdom 1 United States 14 Global 115

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

ITIC MEDCHEM(SUZHOU) CO.,LTD.

Tel: 0512-68323967 18015559028
Fax: +86-512-69200360
Email: sales@iticmedchem.com
Country: China
ProdList: 506
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
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TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
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TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
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TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
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Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
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View Lastest Price from BOC-MET-OL manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-Met-ol 51372-93-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-02-04

51372-93-1, BOC-MET-OLRelated Search:

BOC-D-ALLO-ILE-OH BOC-MET-OL BOC-MET-OSU BOC-MET-OH DCHA BOC-L-Methionine 4-N-BOC-AMINO-4-CARBOXYTETRAHYDROTHIOPYRAN BOC-MET(O)-OH L-Methioninol BPOC-MET-OH DCHA BOC-HOMOCYS(TRT)-OH (S)-2-(BOC-AMINO)-4-(4-METHYL-BENZYLSULFANYL)BUTYRIC ACID BOC-MET(O2)-OH BOC-2-AMINO-4-(ETHYL(THIO))BUTYRIC ACID BOC-HOCYS(BZL)-OH BOC-L-MET-O-CH2-PHI-CH2-COOH BOC-L-MET(O)-O-CH2-PHI-CH2-COOH DCHA BOC-MET-ONP BOC-L-BUTHIONINESULFOXIMINE

N-ALPHA-T-BOC-L-METHIONINOL

N-BOC-L-METHIONINOL

N-(TERT-BUTOXYBUTOXYCARBONYL)-L-METHIONINOL

N-T-BUTOXYCARBONYL-L-METHIONINOL

BOC-L-METHIONINOL

BOC-MET-OL

BOC-METHIONINOL

BOC-(S)-2-AMINO-4-METHYLTHIO-1-BUTANOL

BOC-D-MET-OL

NALPHA-tert-Butoxycarbonyl-L-methioninol

(S)-2-t-Butyloxycarbonyl-amino-4-methylthio-1-butanol, N-alpha-t-Butyloxycarbonyl-L-methioninol

N-(tert-Butoxycarbonyl)-L-Methioninol

Tert-butyl N-[(2s)-1-hydroxy-4-Methylsulfanylbutan-2-yl]carbaMate

Boc-L-Met-OL

(S)-tert-Butyl(1-hydroxy-4-(methylthio)butan-2-yl)carbamate

N-(tert-Butoxycarbonyl)-L-methioninol &gt

Carbamic acid, N-[(1S)-1-(hydroxymethyl)-3-(methylthio)propyl]-, 1,1-dimethylethyl ester

ert-butylN-[(2S)-1-hydroxy-4-methylsulfanylbutan-2-yl]carbamate

(S)-2-(Boc-amino)-4-methylthio-1-butanol

(S)-2-(tert-Butoxycarbonyl)amino-4-methylthio-1-butanol

BOC-MET-OL USP/EP/BP

<i>N</i>-(<i>tert</i>-Butoxybutoxycarbonyl)-<sc>L</sc>-methioninol

51372-93-1

C10H21NO3S

Amino Acid Derivatives

Amino Acids