7-Chloro-1H-pyrrolo[3,2-b]pyridine

Product Name: 7-Chloro-1H-pyrrolo[3,2-b]pyridine
CAS No.: 357263-48-0
Chemical Name: 7-Chloro-1H-pyrrolo[3,2-b]pyridine
Synonyms: 7-Chloro-4-azaindole;7-chloro-1H-pyrrolo[3;7-Chloro-4-azaindole 7-;7-Chloro-1H-pyrrolo[3,2-b...;7-CHLORO-1H-PYRROLO[3,2-B]PYRIDINE;1H-Pyrrolo[3,2-b]pyridine, 7-chloro-;7-CHLORO-1H-PYRROLO[3,2-B]PYRIDINE ISO 9001：2015 REACH
CBNumber: CB8119218
Molecular Formula: C7H5ClN2
Formula Weight: 152.58
MOL File: 357263-48-0.mol

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7-Chloro-1H-pyrrolo[3,2-b]pyridine Property

Boiling point:: 290.6±20.0 °C(Predicted)
Density: 1.425
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 13.08±0.40(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C7H5ClN2/c8-5-1-3-9-6-2-4-10-7(5)6/h1-4,10H
InChIKey: ZBEYLQBHTDNDDR-UHFFFAOYSA-N
SMILES: C12C=CNC1=C(Cl)C=CN=2

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B418688
Product name: 7-Chloro-1H-pyrrolo[3,2-b]pyridine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B418688
Product name: 7-Chloro-1H-pyrrolo[3,2-b]pyridine
Packaging: 500mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: W5724
Product name: 7-Chloro-4-azaindole
Packaging: 1g
Price: $116
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC142288
Product name: 7-Chloro-4-azaindole
Packaging: 500mg
Price: $175
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC142288
Product name: 7-Chloro-4-azaindole
Packaging: 1g
Price: $280
Updated: 2021/12/16

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7-Chloro-1H-pyrrolo[3,2-b]pyridine Chemical Properties,Usage,Production

Synthesis

1116136-36-7

357263-48-0

General procedure for the synthesis of 7-chloro-1H-pyrrolo[3,2-b]pyridine from 4-azaindole-4-oxide: 1H-pyrrolo[3,2-b]pyridine-4-oxide (33 g, 246.27 mmol, 1.00 equiv.) was added to a 1000 mL round bottom flask. To the mixture was added phosphorus trichloride (POCl3, 165.3 g). The resulting solution was stirred in an oil bath at 80 °C for overnight reaction. Upon completion of the reaction, the reaction mixture was quenched by slowly adding 400 mL of water. The pH of the reaction mixture was adjusted to 7-8 with sodium hydroxide (NaOH) solution. the aqueous phase was extracted three times with ethyl acetate (EtOAc, 400 mL), the organic layers were combined and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the organic phase was concentrated under reduced pressure using a rotary evaporator to give 33 g (88% yield) of 7-chloro-1H-pyrrolo[3,2-b]pyridine as a yellow solid.

References

[1] Patent: WO2009/23844, 2009, A2. Location in patent: Page/Page column 140-141
[2] Patent: WO2017/59080, 2017, A1. Location in patent: Page/Page column 195
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 13, p. 5728 - 5737
[4] Patent: US2015/94328, 2015, A1. Location in patent: Paragraph 0363; 0364; 0365
[5] Patent: WO2015/49574, 2015, A1. Location in patent: Page/Page column 40

7-Chloro-1H-pyrrolo[3,2-b]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Chloro-1H-pyrrolo[3,2-b]pyridine Suppliers

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View Lastest Price from 7-Chloro-1H-pyrrolo[3,2-b]pyridine manufacturers

Career Henan Chemical Co

Product: 7-CHLORO-1H-PYRROLO[3,2-B]PYRIDINE 357263-48-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98$
Supply Ability: 200kg
Release date: 2019-08-30

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7-CHLORO-1H-PYRROLO[3,2-B]PYRIDINE ISO 9001：2015 REACH

357263-48-0

257263-48-0

Azaindoles