Isoprothiolane

ChemicalBook > CAS DataBase List > Isoprothiolane

Product Name: Isoprothiolane
CAS No.: 50512-35-1
Chemical Name: Isoprothiolane
Synonyms: IPT;Propanedioicacid,1,3-dithiolan-2-ylidene-,bis(1-methylethyl)ester;fuji1;nkk100;Fuji 1;ISORAN;VIFUSI;NNF-109;NKK 100;ss11946
CBNumber: CB8119935
Molecular Formula: C12H18O4S2
Formula Weight: 290.4
MOL File: 50512-35-1.mol

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Isoprothiolane Property

Melting point:: 54°C
Boiling point:: 402.48°C (rough estimate)
Density: 1.3402 (rough estimate)
vapor pressure: 1.9 Pa (25 °C)
refractive index: 1.4950 (estimate)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
Water Solubility: 54 mg l^-1 (25 °C)
BRN: 2128528
CAS DataBase Reference: 50512-35-1(CAS DataBase Reference)
NIST Chemistry Reference: Propanedioic acid, 1,3-dithiolan-2-ylidene-, bis(1-methylethyl) ester(50512-35-1)
EPA Substance Registry System: Propanedioic acid, 1,3-dithiolan-2-ylidene-, bis(1-methylethyl) ester (50512-35-1)

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-51/53
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HS Code: 29341000
Toxicity: LD50 oral in rabbit: 2320mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 76547
Product name: Isoprothiolane
Purity: PESTANAL?, analytical standard
Packaging: 50mg
Price: $129
Updated: 2024/03/01

Adipogen Life Sciences

Product number: CDX-I0048-M500
Product name: Isoprothiolane
Purity: ≥98%(HPLC)
Packaging: 500mg
Price: $141
Updated: 2021/12/16

AK Scientific

Product number: J10825
Product name: Isoprothiolane
Packaging: 100mg
Price: $151.7
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PST0000104
Product name: ISOPROTHIOLANE
Purity: 95.00%
Packaging: 250MG
Price: $721.88
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PST0000104
Product name: ISOPROTHIOLANE
Purity: 95.00%
Packaging: 2.5G
Price: $1815
Updated: 2021/12/16

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Isoprothiolane Chemical Properties,Usage,Production

Uses

Isoprothiolane is a dithiolane pesticide. Isoprothiolane is commonly used in agriculture as a fungicide to control planthoppers and blast disease in rice plants.

Uses

Isoprothiolane is a fungicide that is used to control rice blast (Pyriculuriu aryzae), rice stem rot and Fusarium leaf spot on rice. It also reduces the plant-hopper population on rice.

Definition

ChEBI: Isoprothiolane is a malonate ester that is diisopropyl malonate in which the two methylene hydrogens at position 2 are replaced by a 1,3-dithiolan-2-ylidene group. An insecticide and fungicide used to control a range of diseases including Pyricularia oryzae, Helminthosporium sigmoideum and Fusarium nivale. It has a role as an insecticide, an environmental contaminant, a phospholipid biosynthesis inhibitor and an antifungal agrochemical. It is a malonate ester, a member of dithiolanes and an isopropyl ester. It is functionally related to a malonic acid. It derives from a hydride of a 1,3-dithiolane.

Hazard

Moderately toxic by ingestion.

Metabolic pathway

Isoprothiolane is easily oxidized by rat liver 9000 g supernatant to produce its racemic sulfoxide in this process, NADPH is an effective cofactor but NADH is not. The liver microsomes, however, preferentially form its (?+)-isomer in an enantiomeric excess of 38-43%. The sulfoxidation of isoprothiolane by rice plants proceeds too slowly to determine the metabolites. Both isoprothiolane (+?)- and (-)- sulfoxides undergo rapid racemization by rat cytosol (105 000 g supernatant) or rice plants, accompanied with reduction to isoprothiolane.

Degradation

Half-lives of isoprothiolane in river water were greater than 50 days (Hayakawa et. al., 1992). The compound is decomposed slowly in deionised water under UV light or sunlight. In rice paddy water, photodegradation was greatly accelerated by the presence of natural organic constituents (Chou and Eto, 1980; Eto et al., 1979). Isoprothiolane was placed on a silica gel TLC plate and irradiated at 10 cm distance with a 10 W lamp emitting mainly at 254 nm. Isoprothiolane photodegraded rapidly (half-life about 3 hours). Five products were detected. Proposed pathways of photodegradation are shown in Scheme 1 and involved cleavage of the dithiolane ring, ester hydrolysis, decarboxylation and the formation of dimeric heterocyclic compounds. The identities of oxalic acid (2), dithiolanylidenemalonic acid (3), dithiolanylideneacetic acid (4), 2,4- bis[bis(isopropoxycarbonyl)methylene]-1,3-dithietane (5), 3,5-bis[bis(isopropoxycarbonyl) methylene]-1,2,4-trithiolane (6) and elemental sulfur were confirmed. Isoprothiolane degraded more rapidly on sand than on a glass plate (Chou and Eto, 1980).

Isoprothiolane Preparation Products And Raw materials

Raw materials

Diisopropyl malonate Isopropylmalonic acid Hexane Carbon disulfide Sodium cyanide Benzene MALONIC ACID DISODIUM SALT Isopropyl alcohol Dichloroethane Sulfuric acid Sodium chloroacetate

Preparation Products

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View Lastest Price from Isoprothiolane manufacturers

Career Henan Chemical Co

Product: Isoprothiolane 50512-35-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-07

50512-35-1, IsoprothiolaneRelated Search:

Diisopropyl phosphite Dimethyl malonate Diethyl methylmalonate 2,2-Dimethyl-1,3-dioxane-4,6-dione Cyclopentane Diisopropyl malonate Malonic acid Diethyl malonate Bromocyclopentane N-isopropyldopamine Apremilast Impurity 28 Apremilast Impurity 19 IpratropiuM BroMide IMpurity F (Mixture of DiastereoMers) Apremilast impurity 19 Exemestane Impurity 13 7-HYDROXY METHOTREXATE-D3 Sofosbuvir Impurity 19 17-Beta-Hydroxy Exemestane Epoxide

fuji1

NKK 100

nkk100

NNF-109

Propanedioic acid, 1,3-dithiolan-2-ylidene-, bis(1-methylethyl) ester

Propanedioicacid,1,3-dithiolan-2-ylidene-,bis(1-methylethyl)ester

SS 11946

ss11946

Di-isopropyl 1,3-dithiolane-2-ylidenemalonate

1,3-dithiolan-2-ylidene-propanedioicacibis(1-methylethyl)ester

Isoprothiolane Solution, 1000ppm

2-(1,3-dithiolan-2-ylidene)propanedioic acid dipropan-2-yl ester

Diisopropyl 2-(1,3-dithiolan-2-ylidene)malonate

di-Isopropyl1,3-dithiolan-2-ylidenemalonate

Diisopropyl1,3-dithiolan-2-ylidenemalonate

di-isopropyl1,3-dithiolane-2-ylidenemalonate

diisopropyl-2(1,3-dithiolan-2-ylidene)malonate

Fudiolan

Fuji 1

ISOPROTHIOLANE

ISORAN

DI-ISOPROPYL 1,3-DITHIOLAN-2-YLINDENE MALONATE

IPT

FUJI-ONE

FUJI-ONE(R)

Bis(1-methylethyl) 1,3-dithiolan-2-ylidenepropanedioate

VIFUSI

Di-isopropyl 1,3-dithiolan-2-vinylmalonate

Isoprothiolane Standard

isoprothiolane (bsi,jmaf,draft e-iso,draft f-iso)

1,3-DITHIOLAN-2-YLIDENEPROPANEDIOICACIDBIS(1-METHYLETHYL)ESTER

Isoprothiolane E.C.

Isoprothiolane W.P.

Isoprothiolane 250mg [50512-35-1]

2-(1,3-Dithiolan-2-ylidene)propanedioic Acid1,3-Bis(1-Methylethyl) Ester

PT (pesticide)

Isoprothiolane@1000 μg/mL in Acetone

Isoprothiolane @100 μg/mL in Methanol

IsoprothiolaneSolution,100mg/L,1ml

Propanedioic acid, 2-(1,3-dithiolan-2-ylidene)-, 1,3-bis(1-methylethyl) ester

Vilanterol Impurity 62

Isoprothiolane Solution in Methanol

50512-35-1

C12H18O4S2

FUNGICIDE