ISOXATHION Property

Melting point:

<25℃

Boiling point:

160°C (rough estimate)

Density 

1.48 g/ml

vapor pressure 

<1.3 x 10^-4 Pa (25 °C)

storage temp. 

0-6°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

Water Solubility 

1.9 mg l^-1 (25 °C)

pka

-6.17±0.28(Predicted)

form 

liquid

color 

Colourless to Pale Yellow

Specific Gravity

1.48

BRN 

1222135

EPA Substance Registry System

Isoxathion (18854-01-8)

Safety

Hazard Codes 

T,N

Risk Statements 

24/25-50/53

Safety Statements 

28-36/37-45-60-61

RIDADR 

3018

WGK Germany 

3

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29349990

Hazardous Substances Data

18854-01-8(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

ISOXATHION Chemical Properties,Usage,Production

Description

Isoxathion is a pale yellow liquid, bp 160 ?C/0.15 mm Hg, vp <0.133mPa (25 ?C). Solubility in water is 1.9 mg/L (25 ?C). It is readily soluble in most organic solvents. Log Kow = 3.88. It is unstable to alkali.

Uses

Isoxathion is used to control sucking pests, leaf miners and some chewing pests in a variety of fruit, vegetables and ornamental plants.

Uses

Isoxathion is used as a pesticide.

Definition

ChEBI: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group is replaced by a 5-phenyl-1,2-oxazol-3-yl group.

Metabolic pathway

The principal route of isoxathion metabolism in soil, plants and mammals is by hydrolysis, probably via the oxon to 3-hydroxy-5-phenylisoxazole which is rapidly conjugated in both plants and rats. In soils, and to a lesser extent in plants and mammals, further metabolism of 3-hydroxy- 5-phenylisoxazole proceeds via opening of the isoxazole ring to give various metabolites of which benzoic acid is one of the more important. De-ethylation of the phosphate moiety has not been observed.

Metabolism

The principal degradation route of isoxathion in animals, plants, and soil is cleavage of P?O-isoxazole through oxidative desulfuration to the oxon followed by hydrolysis to 3-hydroxy-5-phenylisoxazole, which is conjugated in both plants and rats.

Toxicity evaluation

The acute oral LD₅₀ for rats is 112 mg/kg. NOEL (2 yr) for rats is 1.2 mg/kg b.w. DT₅₀ in soil is 9–40 d.

Degradation

Isoxathion is unstable to alkalis (PM). The hydrolysis product, 3-hydroxy- 5-phenylisoxazole (2), yielded 5-phenyl-3H-oxazolin-2-one (3) as the major photoproduct via a photolytic rearrangement (Nakagawa et al.,1974).