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Tetraethylene glycol p-toluenesulfonate

Product Name
Tetraethylene glycol p-toluenesulfonate
CAS No.
77544-60-6
Chemical Name
Tetraethylene glycol p-toluenesulfonate
Synonyms
PEG5-Tos;Tos-PEG4;Tos-PEG4-OH;OH-PEG4-Tos;PEG5-Tosylate;Hydroxy-PEG5-Tos;HO-(CH2CH2O)4-Tos;Tetraethylene glycol tosylate;Tetraethylene glycol monotosylate;Monotosylated tetraethylene glycol
CBNumber
CB81231414
Molecular Formula
C15H24O7S
Formula Weight
348.41
MOL File
77544-60-6.mol
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Tetraethylene glycol p-toluenesulfonate Property

Boiling point:
492.5±40.0 °C(Predicted)
Density 
1.202 g/mL at 25 °C
refractive index 
n20/D1.507
Flash point:
>110℃
storage temp. 
2-8°C
solubility 
Soluble in Water, DMSO, DCM, DMF
form 
Oil
pka
14.36±0.10(Predicted)
color 
Colourless
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Safety

Hazard Codes 
T,Xi
Risk Statements 
25-34-36
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2927 8(6.1) / PGII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
764388
Product name
Tetraethylene glycol p-toluenesulfonate
Purity
97%
Packaging
1g
Price
$72.5
Updated
2024/03/01
TRC
Product number
H533740
Product name
2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
Packaging
200mg
Price
$160
Updated
2021/12/16
SynQuest Laboratories
Product number
6664-1-06
Product name
Tetraethylene glycol p-toluenesulfonate
Purity
97%
Packaging
1g
Price
$104
Updated
2021/12/16
AK Scientific
Product number
Y4976
Product name
Tetraethylene glycol p-toluenesulfonate
Packaging
1g
Price
$147
Updated
2021/12/16
SynQuest Laboratories
Product number
6664-1-06
Product name
Tetraethylene glycol p-toluenesulfonate
Purity
97%
Packaging
250mg
Price
$75
Updated
2021/12/16
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Tetraethylene glycol p-toluenesulfonate Chemical Properties,Usage,Production

Description

PEG5-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Uses

Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

Preparation

Synthesis of tetraethylene glycol tosylate. To a solution of tetraethylene glycol (2.22 g, 11.4 mmol, 3.8 equiv) in THF at 0 °C was added 2.5 M NaOH (2 mL, 5.0 mmol, 1.7 equiv) and stirred for 30 min. Tosyl chloride (565.3 mg, 3.0 mmol, 1 equiv) was added in small portions and the mixture stirred for 5 h. The solvent was removed under reduced pressure, and the residue was taken up in CH2Cl2 (15 mL) and washed with water (3 × 10 mL). The aqueous wash was further extracted with CH2Cl2 (3 × 10 mL) and the combined organic fractions were washed with brine and dried over anhydrous Na2SO4. The dried solution was filtered and the filtrate was concentrated under reduced pressure to give 900.8 mg of a pale yellow oil (87%). The product was sufficiently pure to be used without further purification.

Tetraethylene glycol p-toluenesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tetraethylene glycol p-toluenesulfonate manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
OH-PEG4-Tos 77544-60-6
Price
US $0.00/g
Min. Order
10g
Purity
>98.00%
Supply Ability
10g
Release date
2024-03-25

77544-60-6, Tetraethylene glycol p-toluenesulfonateRelated Search:

Hydroxy-PEG4-C2-PFP ester Hydroxy-PEG7-C2-PFP ester 1-METHANESULFONYL-11-HYDROXY-3,6,9-TRIOXAUNDECANE PEG6-Tos TETRAETHYLENE GLYCOL DI-P-TOSYLATE m-PEG5-Tos 2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate TRI(ETHYLENE GLYCOL) MONOMETHYL ETHER TOSYLATE BroMoMethyl -phosphonic acid diethyl ester Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate) Hydroxy-PEG5-C2-PFP ester PEG13-Tos PEG7-Tos Hydroxy-PEG3-PFP ester 2-(4-Methylphenyl)sulfonyloxyethanol Tos-PEG10-OH Hydroxy-PEG1-C2-PFP ester PEG8-Tos

  • 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
  • 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
  • 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl toluene-4-sulfonate
  • 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl toluenesulfonate
  • 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl tosylate
  • Monotosylated tetraethylene glycol
  • Tetraethylene glycol monotosylate
  • Tetraethylene glycol p-toluenesulfonate
  • Tetraethylene glycol p-toluenesulfonate 97%
  • PEG5-Tos
  • Tos-PEG4-OH
  • Ethanol,2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1-(4-Methylbenzenesulfonate)
  • Hydroxy-PEG5-Tos
  • Tos-PEG4
  • 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)
  • Ethanol,2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-,4-methylbenzenesulfonate
  • 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl p-Toluenesul
  • p-Toluenesulfonic Acid 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl Ester
  • 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-1-tosylethanol
  • OH-PEG4-Tos
  • HO-(CH2CH2O)4-Tos
  • Tos-PEG4-OH/Ethanol, 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1-(4-methylbenzenesulfonate)
  • PEG5-Tosylate
  • Tetraethylene glycol tosylate
  • 77544-60-6
  • 7544-60-6
  • C13H20O6S
  • peg