m-PEG5-Tos
- Product Name
- m-PEG5-Tos
- CAS No.
- 62921-76-0
- Chemical Name
- m-PEG5-Tos
- Synonyms
- m-PEG5-Tos;m-PEG5-OTs;MPEG5-TOSYLATE;(CH3(OCH2CH2)4OTs);TosO-(CH2CH2O)4-Me;2,5,8,11-tetraoxatridecan-13-ol tosylate;2,5,8,11-Tetraoxatridecan-13-ol, 4-methylbenzenesulfonate;3,6,9,12-Tetraoxatridecan-1-ol, 1-(4-methylbenzenesulfonate);2,5,8,11-Tetraoxatridecan-13-yl 4-methylbenzenesulfonate - [T58845];2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
- CBNumber
- CB73062581
- Molecular Formula
- C16H26O7S
- Formula Weight
- 362.44
- MOL File
- 62921-76-0.mol
m-PEG5-Tos Property
- Boiling point:
- 468.3±40.0 °C(Predicted)
- Density
- 1.164±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T58845
- Product name
- 2,5,8,11-Tetraoxatridecan-13-yl4-methylbenzenesulfonate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $30
- Updated
- 2021/12/16
- Product number
- T58845
- Product name
- 2,5,8,11-Tetraoxatridecan-13-yl4-methylbenzenesulfonate
- Purity
- 95%
- Packaging
- 1g
- Price
- $74
- Updated
- 2021/12/16
- Product number
- AMTGC545
- Product name
- 2,5,8,11-Tetraoxatridecan-13-yl4-methylbenzenesulfonate
- Packaging
- 250mg
- Price
- $129
- Updated
- 2021/12/16
- Product number
- AS118354
- Product name
- 2,5,8,11-Tetraoxatridecan-13-yl 4-methylbenzenesulfonate
- Purity
- 97+%
- Packaging
- 250mg
- Price
- $147
- Updated
- 2021/12/16
- Product number
- T58845
- Product name
- 2,5,8,11-Tetraoxatridecan-13-yl4-methylbenzenesulfonate
- Purity
- 95%
- Packaging
- 5g
- Price
- $225
- Updated
- 2021/12/16
m-PEG5-Tos Chemical Properties,Usage,Production
Description
m-PEG5-Tos is a PEG linker containing a tosyl group. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
m-PEG4-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-b). m-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277)[1].
Synthesis
23783-42-8
98-59-9
62921-76-0
1. tetraethylene glycol monomethyl ether (2,5,8,11-tetraoxatridecan-13-ol, 5.0 g, 24.01 mmol) was dissolved in tetrahydrofuran (THF, 20.01 mL). 2. To the above solution, pyridine (5.83 mL, 72.0 mmol) and p-toluenesulfonyl chloride (4-methylbenzene-1-sulfonyl chloride, 5.49 g, 28.8 mmol) were added sequentially. 3. The reaction mixture was stirred at room temperature overnight. 4. Upon completion of the reaction, the reaction mixture was concentrated by rotary evaporator. 5. The concentrated residue was dissolved in dichloromethane. 6. 6. The organic phase was washed twice with saturated aqueous sodium bicarbonate. 7. 7. Combine the aqueous phases and back-extract with methylene chloride. 8. 8. All organic phases were combined and washed twice with 1N hydrochloric acid and once with saturated saline. 9. The organic phase was dried with anhydrous magnesium sulfate (MgSO?), filtered and concentrated to afford the target product 2,5,8,11-tetraoxatridecan-13-yl 4-methylbenzenesulfonate (4.12 g, 11.37 mmol, 47.3% yield), which could be used for the subsequent reaction without further purification.
IC 50
PEGs
References
[1] Yuxia Zhao, et al. Derivative of silybin ethers, and synthetic method and application thereof. Patent CN105037337A.
m-PEG5-Tos Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from m-PEG5-Tos manufacturers
- Product
- m-PEG5-Tos 62921-76-0
- Price
- US $0.00/g
- Min. Order
- 25g
- Purity
- >98.00%
- Supply Ability
- 25g
- Release date
- 2024-03-27