Tetraethylene glycol p-toluenesulfonate
- Product Name
- Tetraethylene glycol p-toluenesulfonate
- CAS No.
- 77544-60-6
- Chemical Name
- Tetraethylene glycol p-toluenesulfonate
- Synonyms
- PEG5-Tos;Tos-PEG4;Tos-PEG4-OH;OH-PEG4-Tos;PEG5-Tosylate;Hydroxy-PEG5-Tos;HO-(CH2CH2O)4-Tos;Tetraethylene glycol tosylate;Tetraethylene glycol monotosylate;Monotosylated tetraethylene glycol
- CBNumber
- CB81231414
- Molecular Formula
- C15H24O7S
- Formula Weight
- 348.41
- MOL File
- 77544-60-6.mol
Tetraethylene glycol p-toluenesulfonate Property
- Boiling point:
- 492.5±40.0 °C(Predicted)
- Density
- 1.202 g/mL at 25 °C
- refractive index
- n20/D1.507
- Flash point:
- >110℃
- storage temp.
- 2-8°C
- solubility
- Soluble in Water, DMSO, DCM, DMF
- form
- Oil
- pka
- 14.36±0.10(Predicted)
- color
- Colourless
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 25-34-36
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 2927 8(6.1) / PGII
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 764388
- Product name
- Tetraethylene glycol p-toluenesulfonate
- Purity
- 97%
- Packaging
- 1g
- Price
- $72.5
- Updated
- 2024/03/01
- Product number
- H533740
- Product name
- 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
- Packaging
- 200mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 6664-1-06
- Product name
- Tetraethylene glycol p-toluenesulfonate
- Purity
- 97%
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- Y4976
- Product name
- Tetraethylene glycol p-toluenesulfonate
- Packaging
- 1g
- Price
- $147
- Updated
- 2021/12/16
- Product number
- 6664-1-06
- Product name
- Tetraethylene glycol p-toluenesulfonate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
Tetraethylene glycol p-toluenesulfonate Chemical Properties,Usage,Production
Description
PEG5-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Uses
Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.
Preparation
Synthesis of tetraethylene glycol tosylate. To a solution of tetraethylene glycol (2.22 g, 11.4 mmol, 3.8 equiv) in THF at 0 °C was added 2.5 M NaOH (2 mL, 5.0 mmol, 1.7 equiv) and stirred for 30 min. Tosyl chloride (565.3 mg, 3.0 mmol, 1 equiv) was added in small portions and the mixture stirred for 5 h. The solvent was removed under reduced pressure, and the residue was taken up in CH2Cl2 (15 mL) and washed with water (3 × 10 mL). The aqueous wash was further extracted with CH2Cl2 (3 × 10 mL) and the combined organic fractions were washed with brine and dried over anhydrous Na2SO4. The dried solution was filtered and the filtrate was concentrated under reduced pressure to give 900.8 mg of a pale yellow oil (87%). The product was sufficiently pure to be used without further purification.
Tetraethylene glycol p-toluenesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
Tetraethylene glycol p-toluenesulfonate Suppliers
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View Lastest Price from Tetraethylene glycol p-toluenesulfonate manufacturers
- Product
- OH-PEG4-Tos 77544-60-6
- Price
- US $0.00/g
- Min. Order
- 10g
- Purity
- >98.00%
- Supply Ability
- 10g
- Release date
- 2024-03-25