m-PEG3-acid
- Product Name
- m-PEG3-acid
- CAS No.
- 209542-49-4
- Chemical Name
- m-PEG3-acid
- Synonyms
- 3-(2-(2-methoxyethoxy)ethoxy)propanoic acid;mPEG3-COOH;m-PEG3-acid;MeO-PEG3-COOH;mPEG2-CH2COOH;mPEG2-CH2CH2COOH;COOHCH2CH2-PEG2-OME;mPEG2-propionic acid;MeO-(CH2CH2O)2-CH2CH2COOH;3-[2-(2-Methoxyethoxy)ethoxy]propionic acid
- CBNumber
- CB93062565
- Molecular Formula
- C8H16O5
- Formula Weight
- 192.21
- MOL File
- 209542-49-4.mol
m-PEG3-acid Property
- Boiling point:
- 301.7±27.0 °C(Predicted)
- Density
- 1.102±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in Water, DMSO, DCM, DMF
- form
- Liquid
- pka
- 4.28±0.10(Predicted)
- color
- Colorless to light yellow
Safety
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P420490
- Product name
- M-PEG3-Acid
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 4708AQ
- Product name
- 3-(2-(2-methoxyethoxy)ethoxy)propanoicacid
- Packaging
- 250mg
- Price
- $131.6
- Updated
- 2021/12/16
- Product number
- 4708AQ
- Product name
- 3-(2-(2-methoxyethoxy)ethoxy)propanoicacid
- Packaging
- 1g
- Price
- $131.6
- Updated
- 2021/12/16
- Product number
- BP-20981
- Product name
- m-PEG3-acid
- Purity
- 98%
- Packaging
- 100mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- POL0002483
- Product name
- M-PEG3-ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $417.55
- Updated
- 2021/12/16
m-PEG3-acid Chemical Properties,Usage,Production
Description
m-PEG3-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
m-PEG2-CH2CH2COOH is PEG-based based PROTAC linker can be used in the synthesis of PROTACs.
Synthesis
111-77-3
1663-39-4
209542-49-4
The general procedure for the synthesis of 3-(2-(2-methoxyethoxy)ethoxy)propionic acid from diethylene glycol monomethyl ether and tert-butyl acrylate is as follows: 1. 110 mL (0.93 mol) of 2-(2-methoxyethoxy)ethanol and 50 mL of dehydrated THF were added to a 500 mL four-neck flask under argon protection. 2. After cooling the reaction system to 0 °C, 1.4 g (0.06 mol) of sodium metal was slowly added. 3. After confirming that no gas was produced in the reaction solution, a solution of 44 mL (0.31 mol) of tert-butyl acrylate (dissolved in 50 mL of THF) was slowly added dropwise. 4. After the dropwise addition was completed, the reaction system was slowly warmed from 0°C to room temperature and stirred at room temperature for 24 hours. 5. Upon completion of the reaction, THF was removed by distillation under reduced pressure. 6. 100 mL (0.3 mol) of 3 mol/L aqueous sodium hydroxide was added to the residue and stirred for 5 hours. 7. The pH of the reaction solution was adjusted to 2 with 10% aqueous sulfuric acid and then extracted three times with dichloromethane. 8. The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. 9. The crude product was distilled twice under reduced pressure at 140 °C and 0.1 kPa to obtain 14 g of 3-[2-(2-methoxyethoxy)ethoxy]propanoic acid (yield: 24%). The 1H-NMR data of the product 3-[2-(2-methoxyethoxy)ethoxy]propionic acid are as follows: 1H-NMR (DMSO-d6) δ (ppm): 2.67 (q, 2H), 2.51 (q, 2H), 2.07 (s, 3H).
References
[1] Benzo[b]thiophene amide derivative and use thereof. WO2018121607A1.
m-PEG3-acid Preparation Products And Raw materials
Raw materials
Preparation Products
m-PEG3-acid Suppliers
- Tel
- 512-58900862 400-0707518
- Fax
- 0086-512-56765862
- sales@alabiochem.com
- Country
- China
- ProdList
- 970
- Advantage
- 59
- Tel
- +86-028-82550498 +86-19102685862
- Fax
- 086-28-82550468
- sales@pu-kang.com
- Country
- China
- ProdList
- 497
- Advantage
- 58
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 025-58367986 17351780683
- Fax
- QQ3209878052
- amy.xiang@ally-chem.com
- Country
- China
- ProdList
- 354
- Advantage
- 60
- Tel
- 400-8592883
- Fax
- 0731-82251112
- sales@huatengsci.com
- Country
- China
- ProdList
- 5872
- Advantage
- 58
- Tel
- Fax
- -
- 13006575422@163.com
- Country
- China
- ProdList
- 6355
- Advantage
- 58
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28785
- Advantage
- 58
- Tel
- 022-59987777 13552403979
- jia_guoqiang@wuxiapptec.com
- Country
- China
- ProdList
- 22345
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- +86-156-80926068 +86-15680926068
- 1924344760@qq.com
- Country
- China
- ProdList
- 4952
- Advantage
- 58
View Lastest Price from m-PEG3-acid manufacturers
- Product
- mPEG2-CH2CH2COOH 209542-49-4
- Price
- US $186.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 300kg
- Release date
- 2025-11-15
- Product
- m-PEG3-COOH 209542-49-4
- Price
- US $0.00/g
- Min. Order
- 25g
- Purity
- >98.00%
- Supply Ability
- 25g
- Release date
- 2024-03-27