ChemicalBook > CAS DataBase List > m-PEG5-Tos

m-PEG5-Tos

Product Name
m-PEG5-Tos
CAS No.
62921-76-0
Chemical Name
m-PEG5-Tos
Synonyms
m-PEG5-Tos;m-PEG5-OTs;MPEG5-TOSYLATE;(CH3(OCH2CH2)4OTs);TosO-(CH2CH2O)4-Me;2,5,8,11-tetraoxatridecan-13-ol tosylate;2,5,8,11-Tetraoxatridecan-13-ol, 4-methylbenzenesulfonate;3,6,9,12-Tetraoxatridecan-1-ol, 1-(4-methylbenzenesulfonate);2,5,8,11-Tetraoxatridecan-13-yl 4-methylbenzenesulfonate - [T58845];2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
CBNumber
CB73062581
Molecular Formula
C16H26O7S
Formula Weight
362.44
MOL File
62921-76-0.mol
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m-PEG5-Tos Property

Boiling point:
468.3±40.0 °C(Predicted)
Density 
1.164±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Synthonix
Product number
T58845
Product name
2,5,8,11-Tetraoxatridecan-13-yl4-methylbenzenesulfonate
Purity
95%
Packaging
250mg
Price
$30
Updated
2021/12/16
Synthonix
Product number
T58845
Product name
2,5,8,11-Tetraoxatridecan-13-yl4-methylbenzenesulfonate
Purity
95%
Packaging
1g
Price
$74
Updated
2021/12/16
AK Scientific
Product number
AMTGC545
Product name
2,5,8,11-Tetraoxatridecan-13-yl4-methylbenzenesulfonate
Packaging
250mg
Price
$129
Updated
2021/12/16
Activate Scientific
Product number
AS118354
Product name
2,5,8,11-Tetraoxatridecan-13-yl 4-methylbenzenesulfonate
Purity
97+%
Packaging
250mg
Price
$147
Updated
2021/12/16
Activate Scientific
Product number
AS118354
Product name
2,5,8,11-Tetraoxatridecan-13-yl 4-methylbenzenesulfonate
Purity
97+%
Packaging
1g
Price
$288
Updated
2021/12/16
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m-PEG5-Tos Chemical Properties,Usage,Production

Description

m-PEG5-Tos is a PEG linker containing a tosyl group. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

m-PEG4-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-b). m-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277)[1].

Synthesis

23783-42-8

98-59-9

62921-76-0

1. tetraethylene glycol monomethyl ether (2,5,8,11-tetraoxatridecan-13-ol, 5.0 g, 24.01 mmol) was dissolved in tetrahydrofuran (THF, 20.01 mL). 2. To the above solution, pyridine (5.83 mL, 72.0 mmol) and p-toluenesulfonyl chloride (4-methylbenzene-1-sulfonyl chloride, 5.49 g, 28.8 mmol) were added sequentially. 3. The reaction mixture was stirred at room temperature overnight. 4. Upon completion of the reaction, the reaction mixture was concentrated by rotary evaporator. 5. The concentrated residue was dissolved in dichloromethane. 6. 6. The organic phase was washed twice with saturated aqueous sodium bicarbonate. 7. 7. Combine the aqueous phases and back-extract with methylene chloride. 8. 8. All organic phases were combined and washed twice with 1N hydrochloric acid and once with saturated saline. 9. The organic phase was dried with anhydrous magnesium sulfate (MgSO?), filtered and concentrated to afford the target product 2,5,8,11-tetraoxatridecan-13-yl 4-methylbenzenesulfonate (4.12 g, 11.37 mmol, 47.3% yield), which could be used for the subsequent reaction without further purification.

IC 50

PEGs

References

[1] Yuxia Zhao, et al. Derivative of silybin ethers, and synthetic method and application thereof. Patent CN105037337A.

m-PEG5-Tos Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from m-PEG5-Tos manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
m-PEG5-Tos 62921-76-0
Price
US $0.00/g
Min. Order
25g
Purity
>98.00%
Supply Ability
25g
Release date
2024-03-27

62921-76-0, m-PEG5-TosRelated Search:

m-PEG4-aldehyde m-PEG3-acid m-PEG4-Mal MPEG3-CH2CH2COOH TETRAETHYLENEGLYCOL MONOMETHYL ETHER 2,5,8,11,14-Pentaoxahexadecan-16-amine m-PEG5-Mal MPEG4-NHS Benzaldehyde, 4-(3,6,9,12-tetraoxatridec-1-yloxy)- mPEG5-N3 MPEG4-CH2CH2COOH TETRAETHYLENE GLYCOL DI-P-TOSYLATE Tetraethylene glycol p-toluenesulfonate 2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate TRI(ETHYLENE GLYCOL) MONOMETHYL ETHER TOSYLATE BroMoMethyl -phosphonic acid diethyl ester Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate)

  • m-PEG5-OTs
  • m-PEG5-Tos
  • MPEG5-TOSYLATE
  • (CH3(OCH2CH2)4OTs)
  • 3,6,9,12-Tetraoxatridecan-1-ol, 1-(4-methylbenzenesulfonate)
  • 2,5,8,11-tetraoxatridecan-13-ol tosylate
  • TosO-(CH2CH2O)4-Me
  • 2,5,8,11-Tetraoxatridecan-13-ol, 4-methylbenzenesulfonate
  • 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
  • 2,5,8,11-Tetraoxatridecan-13-yl 4-methylbenzenesulfonate - [T58845]
  • 62921-76-0