destruxin B

Product Name: destruxin B
CAS No.: 2503-26-6
Chemical Name: destruxin B
Synonyms: destruxin B;Destruxin B from Metarhizium anisopliae;Destruxin B, from Metarrhizium anisopliae;Destruxin B, 97.5%, from Metarrhizium anisopliae;N-[N-[(R)-2-Hydroxy-4-methyl-1-oxopentyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone;Cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl;Cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl];N-[N-[(2R)-1-Oxo-2-hydroxy-4-methylpentyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone
CBNumber: CB81304031
Molecular Formula: C30H51N5O7
Formula Weight: 593.761
MOL File: 2503-26-6.mol

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destruxin B Property

Melting point:: 234 °C
Boiling point:: 875.0±65.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 10 mg/ml)
form: solid
pka: 13.54±0.70(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Safety

HS Code: 2933790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20429
Product name: Destruxin B
Purity: ≥96%
Packaging: 1mg
Price: $475
Updated: 2024/03/01

Biorbyt Ltd

Product number: orb546170
Product name: Destruxinb
Purity: >98%
Packaging: 200ug
Price: $289
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PST0001171
Product name: DESTRUXIN B
Purity: 95.00%
Packaging: 5MG
Price: $500.63
Updated: 2021/12/16

ApexBio Technology

Product number: C4423
Product name: DestruxinB
Packaging: 1mg
Price: $658
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546170
Product name: Destruxinb
Purity: >98%
Packaging: 1mg
Price: $882.3
Updated: 2021/12/16

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destruxin B Chemical Properties,Usage,Production

Description

Destruxin B (2503-26-6) is a cyclic depsipeptide produced by various species of fungi.1 Induces apoptosis in human nonsmall cell lung cancer cells.2 Displays selective cytotoxic effects on human oral cancer cell lines.3 Inhibits hepatocellular carcinoma cell growth via modulation of the Wnt/β-catenin pathway.4

Uses

Destruxin B is used as part of destruxin-clausenamide insecticide compounds and its applications in controlling pests. It is also studied for its selective apoptotic cell death effects of oral cancer cells treated with destruxin B.

Definition

ChEBI: Destruxin B is a cyclodepsipeptide.

in vitro

the results of a previous study showed that destruxin b exhibited selective and significant time- and dose-dependent inhibitory effects on the viabilities of gnm and tscca cells but not on gf cells. these findings indicated that destruxin b was able to induce tumor specific growth inhibition in cancer cells through bax/bcl-2-mediated intrinsic mitochondrial apoptotic pathway in both time- and dose-dependent manners [1].

in vivo

animal study found that the daily subcutaneously administered destruxin b at 0.6-15 mg/kg was safe and effective in inhibiting the growth of crc cells. in addition, the expression of cleaved poly (adp-ribose) polymerase, bax, as well as active caspase-3 were observed with destruxin b treatment. moreover, the increase in tumor volumes of destruxin b treated groups were significantly lower than those of the mock-treated group [2].

References

1) Pedras et al. (2002), The destruxins: synthesis, biosynthesis, biotransformation, and biological activity; Phytochemistry, 59 579 2) Wu et al. (2013), Destruxin B Isolated from Entomopathogenic Fungus Metarhizium anisopliae Induces Apoptosis via a Bcl-2 Family-Dependent Mitochondrial Pathway in Human Nonsmall Cell Lung Cancer Cells; Evid. Based Complement. Alternat. Med,, 2013 548929 3) Liu et al. (2014), Selective apoptotic cell death effects of oral cancer cells treated with destruxin B; BMC Complement. Altern. Med., 14 207 4) Liu et al. (2014), Destruxin B inhibits hepatocellular carcinoma cell growth through modulation of the Wnt/β catenin signaling pathway and epithelial-mesenchymal transition; Toxicol. In Vitro, 28 552

destruxin B Preparation Products And Raw materials

Raw materials

Preparation Products

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destruxin B Suppliers

China 24 United Kingdom 1 United States 9 Global 34

Alabiotech Inc.

Tel: 001-619-354-5251
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Email: sales@alabiotech-e.com
Country: United States
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BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19741
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
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TargetMol Chemicals Inc.

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Country: United States
ProdList: 38632
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Aladdin Scientific

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Email: sales@aladdinsci.com
Country: United States
ProdList: 52925
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ApexBio Technology

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Focus Biomolecules

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Cayman Chemical Company

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MedChemExpress

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destruxin B

N-[N-[(2R)-1-Oxo-2-hydroxy-4-methylpentyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone

N-[N-[(R)-2-Hydroxy-4-methyl-1-oxopentyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone

Destruxin B, 97.5%, from Metarrhizium anisopliae

Destruxin B from Metarhizium anisopliae

Cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl]

Destruxin B, from Metarrhizium anisopliae

Cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl

2503-26-6