handelin

Product Name: handelin
CAS No.: 62687-22-3
Chemical Name: handelin
Synonyms: handelin;Yejuhualactone;Handelin, 10 mM in DMSO;HANDELIN; YEJUHUALACTONE;6,6'-dihydroxy-6,6',9,9'-tetramethyl-3'-methylene-2,2'-dioxo-2',3a,3',3a',4,5,5',6,6a,6',7,9a,9b,9',9a',9b'-hexadecahydro-4'H-spiro[azuleno[4,5-b]furan-3,10'-[6a,9]ethanoazuleno[4,5-b]furan]-5-yl acetate;Spiro[azuleno[4,5-b]furan-3(2H),10'-[4H-6a,9]ethanoazuleno[4,5-b]furan]-2,2'(3'H)-dione, 4-(acetyloxy)-3a,3'a,4,5,5',6,6',6a,7,9',9a,9'a,9b,9'b-tetradecahydro-6,6'-dihydroxy-6,6',9,9'-tetramethyl-3'-methylene-, (3R,3aR,3'aS,4S,6R,6'R,6aR,6'aR,9'R,9aR,9'aS,9bR,9'bS)-
CBNumber: CB81326400
Molecular Formula: C32H40O8
Formula Weight: 552.66
MOL File: 62687-22-3.mol

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handelin Property

Boiling point:: 731.0±60.0 °C(Predicted)
Density: 1.34±0.1 g/cm3 (20 ºC 760 Torr)
form: Solid
pka: 14.34±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 300396
Product name: Handelin
Packaging: 20mg
Price: $665
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259571
Product name: Handelin
Purity: 98%
Packaging: 10mg
Price: $499.8
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0004138
Product name: HANDELIN
Purity: 95.00%
Packaging: 5MG
Price: $502.14
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259571
Product name: Handelin
Purity: 98%
Packaging: 20mg
Price: $634.1
Updated: 2021/12/16

ChemScene

Product number: CS-0018588
Product name: Handelin
Purity: 99.44%
Packaging: 5mg
Price: $269
Updated: 2021/12/16

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handelin Chemical Properties,Usage,Production

Uses

Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production[1].

Definition

ChEBI: Handelin is a sesterterpenoid.

in vivo

Handelin (Compound 1; 10-20 mg/kg; oral administration; for 30 mintues; male Sprague-Dawley rats) treatment inhibits acute inflammation in carrageenan-induced paw edema model. The serum level of IL-1β is also inhibited by Handelin in a carrageenan-induced paw edema model ^[1].

Animal Model:	Male Sprague-Dawley (SD) rats (150-170 g, 5 weeks old) injected with carrageenan^[1]
Dosage:	10 mg/kg, 20 mg/kg
Administration:	Oral administration; for 30 mintues
Result:	Inhibited acute inflammation in carrageenan-induced paw. The serum level of IL-1β was also inhibited.

References

[1] Y Pyee, et al. Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production. J Nat Prod. 2014 Apr 25;77(4):917-24. DOI:10.1021/np4009877

handelin Preparation Products And Raw materials

Raw materials

Preparation Products

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handelin Suppliers

CHINA 94 United States 7 Global 101

Chengdu Biopurify Phytochemicals Ltd.

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Beijing HuaMeiHuLiBiological Chemical

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ALB Technology Limited

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View Lastest Price from handelin manufacturers

Career Henan Chemical Co

Product: handelin 62687-22-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%HPLC
Supply Ability: 10 tons
Release date: 2020-01-09

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HANDELIN; YEJUHUALACTONE

handelin

Yejuhualactone

6,6'-dihydroxy-6,6',9,9'-tetramethyl-3'-methylene-2,2'-dioxo-2',3a,3',3a',4,5,5',6,6a,6',7,9a,9b,9',9a',9b'-hexadecahydro-4'H-spiro[azuleno[4,5-b]furan-3,10'-[6a,9]ethanoazuleno[4,5-b]furan]-5-yl acetate

Spiro[azuleno[4,5-b]furan-3(2H),10'-[4H-6a,9]ethanoazuleno[4,5-b]furan]-2,2'(3'H)-dione, 4-(acetyloxy)-3a,3'a,4,5,5',6,6',6a,7,9',9a,9'a,9b,9'b-tetradecahydro-6,6'-dihydroxy-6,6',9,9'-tetramethyl-3'-methylene-, (3R,3aR,3'aS,4S,6R,6'R,6aR,6'aR,9'R,9aR,9'aS,9bR,9'bS)-

Handelin, 10 mM in DMSO

62687-22-3