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3-AMINO-6-METHOXYPYRIDAZINE

Product Name
3-AMINO-6-METHOXYPYRIDAZINE
CAS No.
7252-84-8
Chemical Name
3-AMINO-6-METHOXYPYRIDAZINE
Synonyms
6-methoxypyridazin-3-amine;3-PyridazinaMine, 6-Methoxy-;NSC 73703;EOS-62222;Netarsudil Impurity 12;6-Methoxy-3-pyridazinamine;6-Amino-3-methoxypyridazine;3-Methoxy-6-aminopyridazine;3-AMINO-6-METHOXYPYRIDAZINE;6-Methoxy-pyridazin-3-ylamine
CBNumber
CB8134491
Molecular Formula
C5H7N3O
Formula Weight
125.13
MOL File
7252-84-8.mol
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3-AMINO-6-METHOXYPYRIDAZINE Property

Melting point:
108-109℃
Boiling point:
353.5±22.0 °C(Predicted)
Density 
1.224
storage temp. 
2-8°C(protect from light)
form 
Solid
pka
5.84±0.10(Predicted)
InChI
InChI=1S/C5H7N3O/c1-9-5-3-2-4(6)7-8-5/h2-3H,1H3,(H2,6,7)
InChIKey
YPWBPONDYDVMLX-UHFFFAOYSA-N
SMILES
C1(N)=NN=C(OC)C=C1
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A612073
Product name
3-Amino-6-methoxypyridazine
Packaging
100mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-2N
Product name
3-Amino-6-methoxypyridazine
Packaging
1g
Price
$76
Updated
2021/12/16
ChemScene
Product number
CS-0019296
Product name
3-Amino-6-methoxypyridazine
Purity
99.91%
Packaging
10g
Price
$79
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-2N
Product name
3-Amino-6-methoxypyridazine
Packaging
250mg
Price
$40
Updated
2021/12/16
Matrix Scientific
Product number
072012
Product name
3-Amino-6-methoxypyridazine
Purity
95+%
Packaging
1g
Price
$41
Updated
2021/12/16
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3-AMINO-6-METHOXYPYRIDAZINE Chemical Properties,Usage,Production

Description

3-amino-6-methoxypyridazine: a critical pharmaceutical intermediate.
It can be used for pyridopyrimidine compounds with remarkable biological activity or medicines, such as the anticancer drug Ruugeli, which can be used for treating indications such as pain caused by endometriosis, uterine fibroids and advanced prostate cancer. At present, many reports on the preparation method of the compound exist, and various process impurities such as 3-amino-6-chloropyridazine, 3-amino-6-hydroxypyridazine, 3-chloro-6-hydroxypyridazine, 3-dichloropyridazine, 3, 6-dimethoxypyridazine, 3-amino-6-methoxypyridazine, 3-aminopyridazine and the like are often introduced in the process of the conventional synthesis process.

Uses

3-Amino-6-methoxypyridazine is an organic reagent that can be used as a key intermediate in the preparation of Relugoli.

Synthesis

A total of 3.40 g. (0.026 mol) 3-amino-6-chloropyridazine was placed in a Carius tube with a solution of sodium methoxide in methanol [prepared from 0.61 g. (0.027 mol) of clean sodium metal and 50 ml. of methanol], and the Carius tube was sealed. The tube was placed in a Carius furnace for 20 hours. After the tube was cooled and opened, the contents were removed, and the light brown solid was filtered off. The filtrate was evaporated to dryness at room temperature under an air jet. The resulting orange-brown crystalline solid was dissolved in a 60:40 petroleum ether-chloroform solution, treated with activated charcoal and filtered. There was obtained, upon. Talline solid fromn-amyl chloride accompanied by treat- 3 ment with activated charcoal yielded 0.51 g. of a white, crystalline solid 3-amino-6-methoxypyridazine melting at 103-105 ℃.

3-AMINO-6-METHOXYPYRIDAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINO-6-METHOXYPYRIDAZINE Suppliers

Hangzhou Chemtrue Bio-Tech Co.,Ltd.
Tel
0571-86828652 18857119830
Fax
0571-83522824
Email
sales@chemtrue-bio.com
Country
China
ProdList
322
Advantage
58
Jiangsu Vcare PharmaTech Co., Ltd.
Tel
13327700685
Fax
+86-25-58744115
Email
sales@vcarepharmatech.com
Country
China
ProdList
310
Advantage
61
Suzhou Sino Rare Chemical Co., Ltd.
Tel
0512-62857507
Fax
+86-512-62857507
Email
sales@sinorarechem.com
Country
China
ProdList
957
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58
Zhuhai Hairuide Bioscience and Technology Co., Ltd
Tel
0756-7789199 13326687259
Email
sales@zhhairuide.com
Country
China
ProdList
106
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Anhui Cheer-Our Medical technology Co.,Ltd
Tel
0551-63535381 13485700777
Email
gaylen@cheer-our.com
Country
China
ProdList
93
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58
Chengdu D-innovation Pharmaceutical Co.,LTD
Tel
028-85929779 18009044761
Email
pengxing@d-innovation.com
Country
China
ProdList
238
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58
SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166 15883665058
Fax
0838-5675535
Email
nbcxkj@126.com
Country
China
ProdList
667
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J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
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View Lastest Price from 3-AMINO-6-METHOXYPYRIDAZINE manufacturers

Suzhou Nordica Biopharma CO.,LTD
Product
3-Amino-6-methoxypyridazine 7252-84-8
Price
US $45.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2024-10-23
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Relugolix Impurity 5 7252-84-8
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-08-13
Henan Fengda Chemical Co., Ltd
Product
3-AMINO-6-METHOXYPYRIDAZINE 7252-84-8
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09

7252-84-8, 3-AMINO-6-METHOXYPYRIDAZINERelated Search:


  • 3-AMINO-6-METHOXYPYRIDAZINE
  • EOS-62222
  • 6-methoxypyridazin-3-amine
  • 3-AMINO-6-METHOXYPYRIDAZINE, 95+%
  • 6-Methoxy-pyridazin-3-ylamine
  • 6-Methoxy-3-pyridazinamine
  • 3-Methoxy-6-aminopyridazine
  • 6-Amino-3-methoxypyridazine
  • NSC 73703
  • 3-PyridazinaMine, 6-Methoxy-
  • 6-Methoxypyridazin-3-amine, 3-Amino-6-methoxy-1,2-diazine
  • 3-amino-6-methoxypyridazine 6-Methoxy-pyridazin-3-ylamine
  • 3-AMINO-6-METHOXYPYRIDAZINE ISO 9001:2015 REACH
  • TIANFU-CHEM_3-Amino-6-methoxypyridazine 7252-84-8
  • Netarsudil Impurity 12
  • 7252-84-8
  • Pyridines
  • Intermediates