heraclenin
- Product Name
- heraclenin
- CAS No.
- 2880-49-1
- Chemical Name
- heraclenin
- Synonyms
- heraclenin;HERACLENIN (P);Propylparahydroxybenzoatesodium;9-[[3,3-dimethyloxiran-2-yl]methoxy]furo[3,2-g]chromen-7-one;(R)-9-((3,3-Dimethyloxiran-2-yl)methoxy)-7H-furo[3,2-g]chromen-7-one;7H-Furo[3,2-g][1]benzopyran-7-one, 9-[[(2R)-3,3-dimethyl-2-oxiranyl]methoxy]-
- CBNumber
- CB81375246
- Molecular Formula
- C16H14O5
- Formula Weight
- 286.28
- MOL File
- 2880-49-1.mol
heraclenin Property
- Melting point:
- 111℃
- Boiling point:
- 471.4±45.0 °C(Predicted)
- Density
- 1.320±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- color
- White to off-white
- LogP
- 1.680 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H288903
- Product name
- Heraclenin
- Packaging
- 5mg
- Price
- $530
- Updated
- 2021/12/16
- Product number
- orb104766
- Product name
- Heraclenin
- Purity
- >98%,Standard References Grade
- Packaging
- 20mg
- Price
- $569.5
- Updated
- 2021/12/16
- Product number
- orb594495
- Product name
- Heraclenin
- Packaging
- 10mg
- Price
- $591.6
- Updated
- 2021/12/16
- Product number
- orb594495
- Product name
- Heraclenin
- Packaging
- 5mg
- Price
- $472.6
- Updated
- 2021/12/16
- Product number
- CBL0015717
- Product name
- HERACLENIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.04
- Updated
- 2021/12/16
heraclenin Chemical Properties,Usage,Production
Description
Heraclenin is a member of the class of compounds known as psoralens. Psoralens are organic compounds containing a psoralen moiety, which consists of a furan fused to a chromenone to for 7H-furo[3,2-g]chromen-7-one. Heraclenin is practically insoluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Heraclenin can be found in carrot, lemon, and wild carrot, which makes heraclenin a potential biomarker for the consumption of these food products.
Uses
Heraclenin inhibits T cell-receptor-mediated proliferation in human primary T cells in a concentration-dependent manner. Heraclenin also induces apoptosis. While imperatorin induces DNA fragmentation at the G1/S phase of the cell cycle, heraclenin induces DNA fragmentation at the G2/M phases of the cell cycle, thus despite a close structural similarity they induce apoptosis in mechanistically different ways.
Biological Functions
Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Heraclenin displays significant levels of antiplasmodial and moderate levels of antimicrobial activities.
Biological Activity
Heraclenin, a natural furanocoumarin, significantly inhibits T cell receptor-mediated proliferation in human primary T cells in a concentration-dependent manner by targeting nuclear factor of activated T-cells (NFAT).
in vitro
Heraclenin, a furocoumarin with an epoxide group in its side chain, was analyzed to see if it induced structural chromosome aberrations and sister-chromatid exchanges (SCEs) in human lymphocytes in vitro. The results were compared directly with those of imperatorin, which differs from Heraclenin only in lacking an epoxide group. An equally strong clastogenic effect was found for both Heraclenin and imperatorin: the number of metaphases with breaks was increased in both cases by approximately a factor of 6. Heraclenin produced a considerable dose-dependent increase in the SCE rate, i.e., by about 60 induced SCEs/metaphase, whereas imperatorin induced only about 4 SCEs/metaphase.
target
Immunology & Inflammation related | Antifection
heraclenin Preparation Products And Raw materials
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View Lastest Price from heraclenin manufacturers
- Product
- Heraclenin 2880-49-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-07
- Product
- Heraclenin 2880-49-1
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- 98% HPLC
- Supply Ability
- 10g
- Release date
- 2020-08-04
- Product
- heraclenin 2880-49-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-03